Literature DB >> 27308444

PRKD2: A two-pronged kinase crucial for the tumor-supporting activity of HSP90.

Ninel Azoitei1, Stefan Fröhling2, Claudia Scholl2, Thomas Seufferlein1.   

Abstract

PRKD2 plays an important role in tumor cell survival, proliferation, migration, and angiogenesis. We recently reported that cell death and impaired blood vessel formation evoked by inhibition of the HSP90 chaperone in human cancer cells of various tissue origins is mediated by destabilization of PRKD2.

Entities:  

Keywords:  Protein kinase D2; heat shock protein 90 (HSP90) chaperone; hypoxia; nuclear factor kappa B (NF-kB); tumor angiogenesis

Year:  2015        PMID： 27308444      PMCID： PMC4904966          DOI： 10.4161/23723556.2014.981444

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  Affinity-based proteomics reveal cancer-specific networks coordinated by Hsp90.

Authors:  Kamalika Moulick; James H Ahn; Hongliang Zong; Anna Rodina; Leandro Cerchietti; Erica M Gomes DaGama; Eloisi Caldas-Lopes; Kristin Beebe; Fabiana Perna; Katerina Hatzi; Ly P Vu; Xinyang Zhao; Danuta Zatorska; Tony Taldone; Peter Smith-Jones; Mary Alpaugh; Steven S Gross; Nagavarakishore Pillarsetty; Thomas Ku; Jason S Lewis; Steven M Larson; Ross Levine; Hediye Erdjument-Bromage; Monica L Guzman; Stephen D Nimer; Ari Melnick; Len Neckers; Gabriela Chiosis
Journal:  Nat Chem Biol       Date:  2011-09-25       Impact factor: 15.040

Review 2.  Protein kinase D signaling.

Authors:  Enrique Rozengurt; Osvaldo Rey; Richard T Waldron
Journal:  J Biol Chem       Date:  2005-02-08       Impact factor: 5.157

3.  Hypoxia-induced activation of HIF-1: role of HIF-1alpha-Hsp90 interaction.

Authors:  E Minet; D Mottet; G Michel; I Roland; M Raes; J Remacle; C Michiels
Journal:  FEBS Lett       Date:  1999-10-29       Impact factor: 4.124

4.  Protein kinase D2 is a crucial regulator of tumour cell-endothelial cell communication in gastrointestinal tumours.

Authors:  Ninel Azoitei; Ganesh Varma Pusapati; Alexander Kleger; Peter Möller; Rainer Küfer; Felicitas Genze; Martin Wagner; Johan van Lint; Peter Carmeliet; Guido Adler; Thomas Seufferlein
Journal:  Gut       Date:  2010-08-23       Impact factor: 23.059

5.  HSP90 supports tumor growth and angiogenesis through PRKD2 protein stabilization.

Authors:  Ninel Azoitei; Kristina Diepold; Cornelia Brunner; Arefeh Rouhi; Felicitas Genze; Alexander Becher; Hans Kestler; Johan van Lint; Gabriela Chiosis; John Koren; Stefan Fröhling; Claudia Scholl; Thomas Seufferlein
Journal:  Cancer Res       Date:  2014-10-08       Impact factor: 12.701

6.  Novel function of orphan nuclear receptor Nur77 in stabilizing hypoxia-inducible factor-1alpha.

Authors:  Young-Gun Yoo; Myeong Goo Yeo; Dae Kyong Kim; Hyunsung Park; Mi-Ock Lee
Journal:  J Biol Chem       Date:  2004-09-22       Impact factor: 5.157

7.  Nur77 activated by hypoxia-inducible factor-1alpha overproduces proopiomelanocortin in von Hippel-Lindau-mutated renal cell carcinoma.

Authors:  Ji-Woong Choi; Sang Chul Park; Gyeong Hoon Kang; Jun O Liu; Hong-Duk Youn
Journal:  Cancer Res       Date:  2004-01-01       Impact factor: 12.701

8.  Mechanism of hypoxia-induced NF-kappaB.

Authors:  Carolyn Culver; Anders Sundqvist; Sharon Mudie; Andrew Melvin; Dimitris Xirodimas; Sonia Rocha
Journal:  Mol Cell Biol       Date:  2010-08-09       Impact factor: 4.272

9.  Targeting of KRAS mutant tumors by HSP90 inhibitors involves degradation of STK33.

Authors:  Ninel Azoitei; Christopher M Hoffmann; Jana M Ellegast; Claudia R Ball; Kerstin Obermayer; Ulrike Gößele; Britta Koch; Katrin Faber; Felicitas Genze; Mark Schrader; Hans A Kestler; Hartmut Döhner; Gabriela Chiosis; Hanno Glimm; Stefan Fröhling; Claudia Scholl
Journal:  J Exp Med       Date:  2012-03-26       Impact factor: 14.307

10.  Orphan nuclear receptor TR3/Nur77 regulates VEGF-A-induced angiogenesis through its transcriptional activity.

Authors:  Huiyan Zeng; Liuliang Qin; Dezheng Zhao; Xiaolian Tan; Eleanor J Manseau; Mien Van Hoang; Donald R Senger; Lawrence F Brown; Janice A Nagy; Harold F Dvorak
Journal:  J Exp Med       Date:  2006-03-06       Impact factor: 14.307
  10 in total
  4 in total

1.  PRKD2 Promotes Progression and Chemoresistance of AML via Regulating Notch1 Pathway.

Authors:  Qian Liu; Wei Li; Ying Zhou; Jimo Jian; Shijie Han; Chao Liu; Wei Li; Xunxun Zhu; Daoxin Ma; Min Ji; Chunyan Ji
Journal:  Onco Targets Ther       Date:  2019-12-12       Impact factor: 4.147

2.  Effects of NRP1 on angiogenesis and vascular maturity in endothelial cells are dependent on the expression of SEMA4D.

Authors:  Zhi Lyu; Hongwei Jin; Zhijian Yan; Keyan Hu; Hongwei Jiang; Huifang Peng; Huiqin Zhuo
Journal:  Int J Mol Med       Date:  2020-08-03       Impact factor: 4.101

3.  Differential expression of genes associated with T lymphocytes function in septic patients with hypoxemia challenge.

Authors:  Ming Xue; Shi Zhang; Jianfeng Xie; Xiwen Zhang; Feng Liu; Yingzi Huang; Ling Liu; Songqiao Liu; Fengmei Guo; Yi Yang; Weiping Yu; Haibo Qiu
Journal:  Ann Transl Med       Date:  2019-12

Review 4.  Multifaceted Functions of Protein Kinase D in Pathological Processes and Human Diseases.

Authors:  Xuejing Zhang; Jaclyn Connelly; Yapeng Chao; Qiming Jane Wang
Journal:  Biomolecules       Date:  2021-03-23
  4 in total

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