Literature DB >> 27308443

Harnessing the nuclear receptor PPARγ to inhibit the growth of lung adenocarcinoma by rewiring metabolic circuitries.

Paul Yenerall1, Ralf Kittler2.   

Abstract

Altered metabolism and nuclear receptor activity have been reported in various cancer types. Here, we discuss our recent finding that the metabolic state of lung adenocarcinoma cells expressing the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) can be modulated by thiazolidinediones, culminating in accumulation of reactive oxygen species and decreased proliferation.

Entities:  

Keywords:  PPARγ; lung cancer; metabolism; nuclear receptor; targeted therapy

Year:  2015        PMID： 27308443      PMCID： PMC4905022          DOI： 10.4161/23723556.2014.980660

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  9 in total

Review 1.  Nuclear hormone receptors and gene expression.

Authors:  A Aranda; A Pascual
Journal:  Physiol Rev       Date:  2001-07       Impact factor: 37.312

Review 2.  How many drug targets are there?

Authors:  John P Overington; Bissan Al-Lazikani; Andrew L Hopkins
Journal:  Nat Rev Drug Discov       Date:  2006-12       Impact factor: 84.694

3.  Inhibition of cancer cell proliferation by PPARγ is mediated by a metabolic switch that increases reactive oxygen species levels.

Authors:  Nishi Srivastava; Rahul K Kollipara; Dinesh K Singh; Jessica Sudderth; Zeping Hu; Hien Nguyen; Shan Wang; Caroline G Humphries; Ryan Carstens; Kenneth E Huffman; Ralph J DeBerardinis; Ralf Kittler
Journal:  Cell Metab       Date:  2014-09-25       Impact factor: 27.287

4.  Targeted upregulation of pyruvate dehydrogenase kinase (PDK)-4 in slow-twitch skeletal muscle underlies the stable modification of the regulatory characteristics of PDK induced by high-fat feeding.

Authors:  M J Holness; A Kraus; R A Harris; M C Sugden
Journal:  Diabetes       Date:  2000-05       Impact factor: 9.461

5.  Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis.

Authors:  Ralph J DeBerardinis; Anthony Mancuso; Evgueni Daikhin; Ilana Nissim; Marc Yudkoff; Suzanne Wehrli; Craig B Thompson
Journal:  Proc Natl Acad Sci U S A       Date:  2007-11-21       Impact factor: 11.205

6.  An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.

Authors:  Dan Rohle; Janeta Popovici-Muller; Nicolaos Palaskas; Sevin Turcan; Christian Grommes; Carl Campos; Jennifer Tsoi; Owen Clark; Barbara Oldrini; Evangelia Komisopoulou; Kaiko Kunii; Alicia Pedraza; Stefanie Schalm; Lee Silverman; Alexandra Miller; Fang Wang; Hua Yang; Yue Chen; Andrew Kernytsky; Marc K Rosenblum; Wei Liu; Scott A Biller; Shinsan M Su; Cameron W Brennan; Timothy A Chan; Thomas G Graeber; Katharine E Yen; Ingo K Mellinghoff
Journal:  Science       Date:  2013-04-04       Impact factor: 47.728

7.  Research resource: Diagnostic and therapeutic potential of nuclear receptor expression in lung cancer.

Authors:  Yangsik Jeong; Yang Xie; Woochang Lee; Angie L Bookout; Luc Girard; Gabriela Raso; Carmen Behrens; Ignacio I Wistuba; Adi F Gadzar; John D Minna; David J Mangelsdorf
Journal:  Mol Endocrinol       Date:  2012-06-14

8.  Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation.

Authors:  Maria E Figueroa; Omar Abdel-Wahab; Chao Lu; Patrick S Ward; Jay Patel; Alan Shih; Yushan Li; Neha Bhagwat; Aparna Vasanthakumar; Hugo F Fernandez; Martin S Tallman; Zhuoxin Sun; Kristy Wolniak; Justine K Peeters; Wei Liu; Sung E Choe; Valeria R Fantin; Elisabeth Paietta; Bob Löwenberg; Jonathan D Licht; Lucy A Godley; Ruud Delwel; Peter J M Valk; Craig B Thompson; Ross L Levine; Ari Melnick
Journal:  Cancer Cell       Date:  2010-12-09       Impact factor: 38.585

Review 9.  Nuclear receptors: decoding metabolic disease.

Authors:  Junichiro Sonoda; Liming Pei; Ronald M Evans
Journal:  FEBS Lett       Date:  2007-11-20       Impact factor: 4.124
  9 in total
  1 in total

1.  Cancer Cell Plasticity: Rapid Reversal of Chemosensitivity and Expression of Stemness Markers in Lung and Breast Cancer Tumorspheres.

Authors:  Juan Sebastian Yakisich; Neelam Azad; Vivek Kaushik; Anand Krishnan V Iyer
Journal:  J Cell Physiol       Date:  2017-03-31       Impact factor: 6.384
  1 in total

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