Literature DB >> 27308432

Disrupting the dynamic equilibrium of ORAI channels determines the phenotype of malignant cells.

Fabien Vanden Abeele1, Charlotte Dubois1, Yaroslav Shuba2, Natalia Prevarskaya1.   

Abstract

We recently unraveled a finely tuned oncogenic mechanism in which genetic and tumor microenvironment alterations act together on a crucial calcium signaling pathway. This pathway involves an interconnected equilibrium of calcium channels functioning like a binary star system in which ORAI1 homomers and ORAI1/3 heteromers are two companion stars under the influence of each other that orbit around the cancer hallmarks of apoptosis resistance and enhanced proliferation.

Entities:  

Year:  2015        PMID： 27308432      PMCID： PMC4904888          DOI： 10.4161/23723556.2014.975631

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  Orai3--the 'exceptional' Orai?

Authors:  Trevor J Shuttleworth
Journal:  J Physiol       Date:  2011-10-31       Impact factor: 5.182

2.  Capacitative and non-capacitative signaling complexes in human platelets.

Authors:  Alejandro Berna-Erro; Carmen Galan; Natalia Dionisio; Luis J Gomez; Gines M Salido; Juan A Rosado
Journal:  Biochim Biophys Acta       Date:  2012-05-26

3.  A monoclonal antibody that targets a NaV1.7 channel voltage sensor for pain and itch relief.

Authors:  Jun-Ho Lee; Chul-Kyu Park; Gang Chen; Qingjian Han; Rou-Gang Xie; Tong Liu; Ru-Rong Ji; Seok-Yong Lee
Journal:  Cell       Date:  2014-05-22       Impact factor: 41.582

4.  Remodeling of channel-forming ORAI proteins determines an oncogenic switch in prostate cancer.

Authors:  Charlotte Dubois; Fabien Vanden Abeele; V'yacheslav Lehen'kyi; Dimitra Gkika; Basma Guarmit; Gilbert Lepage; Christian Slomianny; Anne Sophie Borowiec; Gabriel Bidaux; Mohamed Benahmed; Yaroslav Shuba; Natalia Prevarskaya
Journal:  Cancer Cell       Date:  2014-06-19       Impact factor: 31.743

5.  Store-independent activation of Orai1 by SPCA2 in mammary tumors.

Authors:  Mingye Feng; Desma M Grice; Helen M Faddy; Nguyen Nguyen; Sharon Leitch; Yingyu Wang; Sabina Muend; Paraic A Kenny; Saraswati Sukumar; Sarah J Roberts-Thomson; Gregory R Monteith; Rajini Rao
Journal:  Cell       Date:  2010-10-01       Impact factor: 41.582

6.  Orai1 and STIM1 are critical for breast tumor cell migration and metastasis.

Authors:  Shengyu Yang; J Jillian Zhang; Xin-Yun Huang
Journal:  Cancer Cell       Date:  2009-02-03       Impact factor: 31.743

7.  Muscarinic receptor activation of arachidonate-mediated Ca2+ entry in HEK293 cells is independent of phospholipase C.

Authors:  T J Shuttleworth; J L Thompson
Journal:  J Biol Chem       Date:  1998-12-04       Impact factor: 5.157

8.  Autonomic nerve development contributes to prostate cancer progression.

Authors:  Claire Magnon; Simon J Hall; Juan Lin; Xiaonan Xue; Leah Gerber; Stephen J Freedland; Paul S Frenette
Journal:  Science       Date:  2013-07-12       Impact factor: 47.728

9.  Orai1 contributes to the establishment of an apoptosis-resistant phenotype in prostate cancer cells.

Authors:  M Flourakis; V Lehen'kyi; B Beck; M Raphaël; M Vandenberghe; F V Abeele; M Roudbaraki; G Lepage; B Mauroy; C Romanin; Y Shuba; R Skryma; N Prevarskaya
Journal:  Cell Death Dis       Date:  2010-09-16       Impact factor: 8.469

Review 10.  Remodeling of calcium signaling in tumor progression.

Authors:  Yih-Fung Chen; Ying-Ting Chen; Wen-Tai Chiu; Meng-Ru Shen
Journal:  J Biomed Sci       Date:  2013-04-17       Impact factor: 8.410
  10 in total

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