Literature DB >> 27308384

Animal model studies indicate a candidate biomarker for sorafenib treatment of hepatocellular carcinoma.

Elad Horwitz1, Ilan Stein2, Yinon Ben-Neriah1, Eli Pikarsky2.   

Abstract

In contrast to common genomic amplifications that support cancer cell growth by rewiring intracellular signaling, VEGFA amplification drives tumor cell proliferation via the tumor microenvironment. VEGFA amplification is present in a subset of mouse and human hepatocellular carcinomas (HCCs) that appear to be particularly sensitive to sorafenib treatment, indicating its potential value as a biomarker for HCC treatment.

Entities:  

Keywords:  HCC; VEGFA; copy number variation; genomic amplification; macrophages; mouse model; sorafenib

Year:  2014        PMID： 27308384      PMCID： PMC4905227          DOI： 10.4161/23723548.2014.968028

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  Human and mouse VEGFA-amplified hepatocellular carcinomas are highly sensitive to sorafenib treatment.

Authors:  Elad Horwitz; Ilan Stein; Mariacarla Andreozzi; Julia Nemeth; Avivit Shoham; Orit Pappo; Nora Schweitzer; Luigi Tornillo; Naama Kanarek; Luca Quagliata; Farid Zreik; Rinnat M Porat; Rutie Finkelstein; Hendrik Reuter; Ronald Koschny; Tom Ganten; Carolin Mogler; Oren Shibolet; Jochen Hess; Kai Breuhahn; Myriam Grunewald; Peter Schirmacher; Arndt Vogel; Luigi Terracciano; Peter Angel; Yinon Ben-Neriah; Eli Pikarsky
Journal:  Cancer Discov       Date:  2014-03-31       Impact factor: 39.397

2.  VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cells.

Authors:  Myriam Grunewald; Inbal Avraham; Yuval Dor; Esther Bachar-Lustig; Ahuva Itin; Steffen Jung; Steffen Yung; Stephano Chimenti; Limor Landsman; Rinat Abramovitch; Eli Keshet
Journal:  Cell       Date:  2006-01-13       Impact factor: 41.582

3.  Focal gains of VEGFA and molecular classification of hepatocellular carcinoma.

Authors:  Derek Y Chiang; Augusto Villanueva; Yujin Hoshida; Judit Peix; Philippa Newell; Beatriz Minguez; Amanda C LeBlanc; Diana J Donovan; Swan N Thung; Manel Solé; Victoria Tovar; Clara Alsinet; Alex H Ramos; Jordi Barretina; Sasan Roayaie; Myron Schwartz; Samuel Waxman; Jordi Bruix; Vincenzo Mazzaferro; Azra H Ligon; Vesna Najfeld; Scott L Friedman; William R Sellers; Matthew Meyerson; Josep M Llovet
Journal:  Cancer Res       Date:  2008-08-15       Impact factor: 12.701

4.  VEGFA gene locus analysis across 80 human tumour types reveals gene amplification in several neoplastic entities.

Authors:  Mariacarla Andreozzi; Luca Quagliata; Joel R Gsponer; Christian Ruiz; Vincent Vuaroqueaux; Serenella Eppenberger-Castori; Luigi Tornillo; Luigi M Terracciano
Journal:  Angiogenesis       Date:  2013-10-11       Impact factor: 9.596

Review 5.  Gene amplification in cancer.

Authors:  Donna G Albertson
Journal:  Trends Genet       Date:  2006-06-19       Impact factor: 11.639

6.  NF-kappaB functions as a tumour promoter in inflammation-associated cancer.

Authors:  Eli Pikarsky; Rinnat M Porat; Ilan Stein; Rinat Abramovitch; Sharon Amit; Shafika Kasem; Elena Gutkovich-Pyest; Simcha Urieli-Shoval; Eithan Galun; Yinon Ben-Neriah
Journal:  Nature       Date:  2004-08-25       Impact factor: 49.962

7.  Angiogenesis-independent endothelial protection of liver: role of VEGFR-1.

Authors:  Jennifer LeCouter; Dirk R Moritz; Bing Li; Gail Lewis Phillips; Xiao Huan Liang; Hans-Peter Gerber; Kenneth J Hillan; Napoleone Ferrara
Journal:  Science       Date:  2003-02-07       Impact factor: 47.728

8.  Sorafenib in advanced hepatocellular carcinoma.

Authors:  Josep M Llovet; Sergio Ricci; Vincenzo Mazzaferro; Philip Hilgard; Edward Gane; Jean-Frédéric Blanc; Andre Cosme de Oliveira; Armando Santoro; Jean-Luc Raoul; Alejandro Forner; Myron Schwartz; Camillo Porta; Stefan Zeuzem; Luigi Bolondi; Tim F Greten; Peter R Galle; Jean-François Seitz; Ivan Borbath; Dieter Häussinger; Tom Giannaris; Minghua Shan; Marius Moscovici; Dimitris Voliotis; Jordi Bruix
Journal:  N Engl J Med       Date:  2008-07-24       Impact factor: 91.245

Review 9.  Focal gains of VEGFA: candidate predictors of sorafenib response in hepatocellular carcinoma.

Authors:  Josep M Llovet
Journal:  Cancer Cell       Date:  2014-05-12       Impact factor: 31.743

10.  Chromosome alterations in human hepatocellular carcinomas correlate with aetiology and histological grade--results of an explorative CGH meta-analysis.

Authors:  P Moinzadeh; K Breuhahn; H Stützer; P Schirmacher
Journal:  Br J Cancer       Date:  2005-03-14       Impact factor: 7.640
  10 in total

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