Literature DB >> 27308380

miR-17-92 explains MYC oncogene addiction.

Yulin Li1, Stephanie C Casey1, Peter S Choi1, Dean W Felsher1.   

Abstract

MYC regulates tumorigenesis by coordinating the expression of thousands of genes. We found that MYC appears to regulate the decisions between cell survival versus death and self-renewal versus senescence through the microRNA miR-17-92 cluster. Addiction to the MYC oncogene may therefore in fact be an addiction to miR-17-92.

Entities:  

Keywords:  MYC; lymphoma; microRNA miR-17-92; oncogene addiction

Year:  2014        PMID： 27308380      PMCID： PMC4905255          DOI： 10.4161/23723548.2014.970092

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

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Authors:  Eric L Greer; Yang Shi
Journal:  Nat Rev Genet       Date:  2012-04-03       Impact factor: 53.242

2.  c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells.

Authors:  Zuqin Nie; Gangqing Hu; Gang Wei; Kairong Cui; Arito Yamane; Wolfgang Resch; Ruoning Wang; Douglas R Green; Lino Tessarollo; Rafael Casellas; Keji Zhao; David Levens
Journal:  Cell       Date:  2012-09-28       Impact factor: 41.582

3.  Transcriptional amplification in tumor cells with elevated c-Myc.

Authors:  Charles Y Lin; Jakob Lovén; Peter B Rahl; Ronald M Paranal; Christopher B Burge; James E Bradner; Tong Ihn Lee; Richard A Young
Journal:  Cell       Date:  2012-09-28       Impact factor: 41.582

4.  MYC through miR-17-92 suppresses specific target genes to maintain survival, autonomous proliferation, and a neoplastic state.

Authors:  Yulin Li; Peter S Choi; Stephanie C Casey; David L Dill; Dean W Felsher
Journal:  Cancer Cell       Date:  2014-08-11       Impact factor: 31.743

Review 5.  mir-17-92, a cluster of miRNAs in the midst of the cancer network.

Authors:  Virginie Olive; Iris Jiang; Lin He
Journal:  Int J Biochem Cell Biol       Date:  2010-03-19       Impact factor: 5.085

Review 6.  MYC on the path to cancer.

Authors:  Chi V Dang
Journal:  Cell       Date:  2012-03-30       Impact factor: 41.582

7.  Genetic dissection of the miR-17~92 cluster of microRNAs in Myc-induced B-cell lymphomas.

Authors:  Ping Mu; Yoon-Chi Han; Doron Betel; Evelyn Yao; Massimo Squatrito; Paul Ogrodowski; Elisa de Stanchina; Aleco D'Andrea; Chris Sander; Andrea Ventura
Journal:  Genes Dev       Date:  2009-12-15       Impact factor: 11.361

8.  Cancer. Addiction to oncogenes--the Achilles heal of cancer.

Authors:  I Bernard Weinstein
Journal:  Science       Date:  2002-07-05       Impact factor: 47.728

9.  B-cell malignancies in microRNA Eμ-miR-17~92 transgenic mice.

Authors:  Sukhinder K Sandhu; Matteo Fassan; Stefano Volinia; Francesca Lovat; Veronica Balatti; Yuri Pekarsky; Carlo M Croce
Journal:  Proc Natl Acad Sci U S A       Date:  2013-10-21       Impact factor: 11.205

Review 10.  Inactivation of MYC reverses tumorigenesis.

Authors:  Y Li; S C Casey; D W Felsher
Journal:  J Intern Med       Date:  2014-07       Impact factor: 8.989
  10 in total
  1 in total

1.  The MYEOV-MYC association promotes oncogenic miR-17/93-5p expression in pancreatic ductal adenocarcinoma.

Authors:  Hongzhang Shen; Fuqiang Ye; Dongchao Xu; Liangliang Fang; Xiaofeng Zhang; Juanjuan Zhu
Journal:  Cell Death Dis       Date:  2021-12-20       Impact factor: 8.469
  1 in total

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