Literature DB >> 27308378

The programmed cell death GLuc PCA library - a powerful tool for pathway discovery and drug screening.

Yuval Gilad1, Adi Kimchi1.   

Abstract

A programmed cell death library based on the Gaussia luciferase protein-fragment complementation assay (GLuc PCA) enables detection of protein-protein interactions (PPI) within the cell death network and quantitative assessments of these interactions. Among future applications for the GLuc PCA cell death library is its potential use as a platform for PPI-targeted drug screening.

Entities:  

Keywords:  DAPK2; apoptosis; autophagy; programmed cell death; protein-fragment complementation assay; protein-protein interaction

Year:  2014        PMID： 27308378      PMCID： PMC4905220          DOI： 10.4161/23723548.2014.969644

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  8 in total

Review 1.  Systems biology analysis of programmed cell death.

Authors:  Shani Bialik; Einat Zalckvar; Yaara Ber; Assaf D Rubinstein; Adi Kimchi
Journal:  Trends Biochem Sci       Date:  2010-05-28       Impact factor: 13.807

2.  A highly sensitive protein-protein interaction assay based on Gaussia luciferase.

Authors:  Ingrid Remy; Stephen W Michnick
Journal:  Nat Methods       Date:  2006-11-12       Impact factor: 28.547

3.  A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions.

Authors:  Marta M Lipinski; Greg Hoffman; Aylwin Ng; Wen Zhou; Bénédicte F Py; Emily Hsu; Xuxin Liu; Jason Eisenberg; Jun Liu; John Blenis; Ramnik J Xavier; Junying Yuan
Journal:  Dev Cell       Date:  2010-06-15       Impact factor: 12.270

4.  Discovering protein-protein interactions within the programmed cell death network using a protein-fragment complementation screen.

Authors:  Yuval Gilad; Ruth Shiloh; Yaara Ber; Shani Bialik; Adi Kimchi
Journal:  Cell Rep       Date:  2014-07-24       Impact factor: 9.423

Review 5.  Self-consumption: the interplay of autophagy and apoptosis.

Authors:  Guillermo Mariño; Mireia Niso-Santano; Eric H Baehrecke; Guido Kroemer
Journal:  Nat Rev Mol Cell Biol       Date:  2014-01-08       Impact factor: 94.444

Review 6.  Principles and current strategies for targeting autophagy for cancer treatment.

Authors:  Ravi K Amaravadi; Jennifer Lippincott-Schwartz; Xiao-Ming Yin; William A Weiss; Naoko Takebe; William Timmer; Robert S DiPaola; Michael T Lotze; Eileen White
Journal:  Clin Cancer Res       Date:  2011-02-15       Impact factor: 12.531

Review 7.  Targeting apoptosis pathways for new cancer therapeutics.

Authors:  Longchuan Bai; Shaomeng Wang
Journal:  Annu Rev Med       Date:  2013-11-04       Impact factor: 13.739

8.  Image-based genome-wide siRNA screen identifies selective autophagy factors.

Authors:  Anthony Orvedahl; Rhea Sumpter; Guanghua Xiao; Aylwin Ng; Zhongju Zou; Yi Tang; Masahiro Narimatsu; Christopher Gilpin; Qihua Sun; Michael Roth; Christian V Forst; Jeffrey L Wrana; Ying E Zhang; Katherine Luby-Phelps; Ramnik J Xavier; Yang Xie; Beth Levine
Journal:  Nature       Date:  2011-12-01       Impact factor: 49.962
  8 in total

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