Literature DB >> 27308375

Divide and rule: The role of ubiquitination in inactivation of the ERK5-MAPK cascade.

Katharina Schulenburg1, Gabor Glatz2, Attila Remenyi2, Krishnaraj Rajalingam3.   

Abstract

Recently, we revealed that ubiquitination of MEKK2 and MEKK3 by inhibitor of apoptosis proteins (IAPs) directly disrupts MEK5/ERK5 interaction and subsequently attenuates ERK5 activation. In addition, loss of XIAP promotes human myogenic differentiation in an ERK5-dependent manner. These results reveal another layer of MAPK regulation and a novel role for XIAP in controlling myogenic differentiation.

Entities:  

Keywords:  ERK5; IAP; MAPK; PB1; XIAP; cIAP1; ubiquitin

Year:  2014        PMID： 27308375      PMCID： PMC4905217          DOI： 10.4161/23723548.2014.969170

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  9 in total

Review 1.  Differential regulation and properties of MAPKs.

Authors:  M Raman; W Chen; M H Cobb
Journal:  Oncogene       Date:  2007-05-14       Impact factor: 9.867

2.  X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility.

Authors:  Taner Dogan; Gregory S Harms; Mirko Hekman; Christiaan Karreman; Tripat Kaur Oberoi; Emad S Alnemri; Ulf R Rapp; Krishnaraj Rajalingam
Journal:  Nat Cell Biol       Date:  2008-11-16       Impact factor: 28.824

Review 3.  IAP proteins: regulators of cell migration and development.

Authors:  Niall S Kenneth; Colin S Duckett
Journal:  Curr Opin Cell Biol       Date:  2012-12-05       Impact factor: 8.382

Review 4.  ERK5: structure, regulation and function.

Authors:  Gopika N Nithianandarajah-Jones; Bettina Wilm; Christopher E P Goldring; Jürgen Müller; Michael J Cross
Journal:  Cell Signal       Date:  2012-07-16       Impact factor: 4.315

5.  IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation.

Authors:  Tripat Kaur Oberoi; Taner Dogan; Jennifer C Hocking; Rolf-Peter Scholz; Juliane Mooz; Carrie L Anderson; Christiaan Karreman; Dagmar Meyer zu Heringdorf; Gudula Schmidt; Mika Ruonala; Kazuhiko Namikawa; Gregory S Harms; Alejandro Carpy; Boris Macek; Reinhard W Köster; Krishnaraj Rajalingam
Journal:  EMBO J       Date:  2011-11-25       Impact factor: 11.598

Review 6.  Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death.

Authors:  Domagoj Vucic; Vishva M Dixit; Ingrid E Wertz
Journal:  Nat Rev Mol Cell Biol       Date:  2011-06-23       Impact factor: 94.444

7.  Ubiquitin-dependent regulation of MEKK2/3-MEK5-ERK5 signaling module by XIAP and cIAP1.

Authors:  Armelle-Natsuo Takeda; Tripat Kaur Oberoi-Khanuja; Gabor Glatz; Katharina Schulenburg; Rolf-Peter Scholz; Alejandro Carpy; Boris Macek; Attila Remenyi; Krishnaraj Rajalingam
Journal:  EMBO J       Date:  2014-06-28       Impact factor: 11.598

Review 8.  Ubiquitylation in immune disorders and cancer: from molecular mechanisms to therapeutic implications.

Authors:  Simone Fulda; Krishnaraj Rajalingam; Ivan Dikic
Journal:  EMBO Mol Med       Date:  2012-06-25       Impact factor: 12.137

9.  Structural mechanism for the specific assembly and activation of the extracellular signal regulated kinase 5 (ERK5) module.

Authors:  Gábor Glatz; Gergő Gógl; Anita Alexa; Attila Reményi
Journal:  J Biol Chem       Date:  2013-02-04       Impact factor: 5.157
  9 in total

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