Literature DB >> 27308363

Pumilio and nanos RNA-binding proteins counterbalance the transcriptional consequences of RB1 inactivation.

Wayne O Miles1, Nicholas J Dyson1.   

Abstract

The ability of the retinoblastoma protein (RB) tumor suppressor to repress transcription stimulated by the E2 promoter binding factors (E2F) is integral to its biological functions. Our recent report described a conserved feedback mechanism mediated by the RNA-binding proteins Pumilio and Nanos that increases in importance following RB loss and helps cells to tolerate deregulated E2F.

Entities:  

Keywords:  NANOS; PUMILIO; RB1; RNA; cancer; p53; post-transcriptional regulation; retinoblastoma

Year:  2014        PMID： 27308363      PMCID： PMC4905203          DOI： 10.4161/23723548.2014.968074

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  Recruitment of Nanos to hunchback mRNA by Pumilio.

Authors:  J Sonoda; R P Wharton
Journal:  Genes Dev       Date:  1999-10-15       Impact factor: 11.361

2.  Pumilio facilitates miRNA regulation of the E2F3 oncogene.

Authors:  Wayne O Miles; Katrin Tschöp; Anabel Herr; Jun-Yuan Ji; Nicholas J Dyson
Journal:  Genes Dev       Date:  2012-02-15       Impact factor: 11.361

Review 3.  The RB protein family in retinal development and retinoblastoma: new insights from new mouse models.

Authors:  Rod Bremner; Danian Chen; Marek Pacal; Izhar Livne-Bar; Mahima Agochiya
Journal:  Dev Neurosci       Date:  2004       Impact factor: 2.984

Review 4.  RB1 in cancer: different mechanisms of RB1 inactivation and alterations of pRb pathway in tumorigenesis.

Authors:  Riccardo Di Fiore; Antonella D'Anneo; Giovanni Tesoriere; Renza Vento
Journal:  J Cell Physiol       Date:  2013-08       Impact factor: 6.384

5.  RBF binding to both canonical E2F targets and noncanonical targets depends on functional dE2F/dDP complexes.

Authors:  Michael Korenjak; Endre Anderssen; Sridhar Ramaswamy; Johnathan R Whetstine; Nicholas J Dyson
Journal:  Mol Cell Biol       Date:  2012-08-27       Impact factor: 4.272

6.  Post-transcriptional gene expression control by NANOS is up-regulated and functionally important in pRb-deficient cells.

Authors:  Wayne O Miles; Michael Korenjak; Lyra M Griffiths; Michael A Dyer; Paolo Provero; Nicholas J Dyson
Journal:  EMBO J       Date:  2014-08-06       Impact factor: 11.598

7.  Human Pumilio proteins recruit multiple deadenylases to efficiently repress messenger RNAs.

Authors:  Jamie Van Etten; Trista L Schagat; Joel Hrit; Chase A Weidmann; Justin Brumbaugh; Joshua J Coon; Aaron C Goldstrohm
Journal:  J Biol Chem       Date:  2012-09-06       Impact factor: 5.157

8.  Differential gene expression profile of retinoblastoma compared to normal retina.

Authors:  Arupa Ganguly; Carol L Shields
Journal:  Mol Vis       Date:  2010-07-13       Impact factor: 2.367

9.  A conserved PUF-Ago-eEF1A complex attenuates translation elongation.

Authors:  Kyle Friend; Zachary T Campbell; Amy Cooke; Peggy Kroll-Conner; Marvin P Wickens; Judith Kimble
Journal:  Nat Struct Mol Biol       Date:  2012-01-08       Impact factor: 15.369

10.  Developmental rescue of an embryonic-lethal mutation in the retinoblastoma gene in chimeric mice.

Authors:  E C Maandag; M van der Valk; M Vlaar; C Feltkamp; J O'Brien; M van Roon; N van der Lugt; A Berns; H te Riele
Journal:  EMBO J       Date:  1994-09-15       Impact factor: 11.598
  10 in total
  1 in total

1.  Nanos promotes epigenetic reprograming of the germline by down-regulation of the THAP transcription factor LIN-15B.

Authors:  Chih-Yung Sean Lee; Tu Lu; Geraldine Seydoux
Journal:  Elife       Date:  2017-11-07       Impact factor: 8.140
  1 in total

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