Literature DB >> 27308359

Revealing human intestinal stem cell and crypt dynamics.

Ann-Marie Baker1, Trevor A Graham1.   

Abstract

Stem cell and crypt dynamics in the human gut have been remarkably poorly characterized. We used random somatic mutations to trace stem cell lineages in the human intestine and coupled these data with mathematical modeling to infer the in vivo temporal dynamics of human intestinal stem cells.

Entities:  

Keywords:  clonal evolution; crypt life-cycle; human intestine; neutral drift; stem cell

Year:  2014        PMID： 27308359      PMCID： PMC4904973          DOI： 10.4161/23723548.2014.970069

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients.

Authors:  Y Miyoshi; H Ando; H Nagase; I Nishisho; A Horii; Y Miki; T Mori; J Utsunomiya; S Baba; G Petersen
Journal:  Proc Natl Acad Sci U S A       Date:  1992-05-15       Impact factor: 11.205

2.  Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells.

Authors:  Hugo J Snippert; Laurens G van der Flier; Toshiro Sato; Johan H van Es; Maaike van den Born; Carla Kroon-Veenboer; Nick Barker; Allon M Klein; Jacco van Rheenen; Benjamin D Simons; Hans Clevers
Journal:  Cell       Date:  2010-10-01       Impact factor: 41.582

3.  Intestinal stem cell replacement follows a pattern of neutral drift.

Authors:  Carlos Lopez-Garcia; Allon M Klein; Benjamin D Simons; Douglas J Winton
Journal:  Science       Date:  2010-09-23       Impact factor: 47.728

4.  A methodological approach to tracing cell lineage in human epithelial tissues.

Authors:  Tariq G Fellous; Stuart A C McDonald; Julia Burkert; Adam Humphries; Shahriar Islam; Nemantha M W De-Alwis; Lydia Gutierrez-Gonzalez; Paul J Tadrous; George Elia; Hemant M Kocher; Satyajit Bhattacharya; Lisa Mears; Mona El-Bahrawy; Douglas M Turnbull; Robert W Taylor; Laura C Greaves; Patrick F Chinnery; Christopher P Day; Nicholas A Wright; Malcolm R Alison
Journal:  Stem Cells       Date:  2009-06       Impact factor: 6.277

5.  Continuous clonal labeling reveals small numbers of functional stem cells in intestinal crypts and adenomas.

Authors:  Sarah Kozar; Edward Morrissey; Anna M Nicholson; Maartje van der Heijden; Heather I Zecchini; Richard Kemp; Simon Tavaré; Louis Vermeulen; Douglas J Winton
Journal:  Cell Stem Cell       Date:  2013-09-12       Impact factor: 24.633

6.  Comparative lesion sequencing provides insights into tumor evolution.

Authors:  Siân Jones; Wei-Dong Chen; Giovanni Parmigiani; Frank Diehl; Niko Beerenwinkel; Tibor Antal; Arne Traulsen; Martin A Nowak; Christopher Siegel; Victor E Velculescu; Kenneth W Kinzler; Bert Vogelstein; Joseph Willis; Sanford D Markowitz
Journal:  Proc Natl Acad Sci U S A       Date:  2008-03-12       Impact factor: 11.205

7.  Identification of stem cells in small intestine and colon by marker gene Lgr5.

Authors:  Nick Barker; Johan H van Es; Jeroen Kuipers; Pekka Kujala; Maaike van den Born; Miranda Cozijnsen; Andrea Haegebarth; Jeroen Korving; Harry Begthel; Peter J Peters; Hans Clevers
Journal:  Nature       Date:  2007-10-14       Impact factor: 49.962

8.  Quantification of crypt and stem cell evolution in the normal and neoplastic human colon.

Authors:  Ann-Marie Baker; Biancastella Cereser; Samuel Melton; Alexander G Fletcher; Manuel Rodriguez-Justo; Paul J Tadrous; Adam Humphries; George Elia; Stuart A C McDonald; Nicholas A Wright; Benjamin D Simons; Marnix Jansen; Trevor A Graham
Journal:  Cell Rep       Date:  2014-08-07       Impact factor: 9.423

9.  Mitochondrial DNA mutations in human colonic crypt stem cells.

Authors:  Robert W Taylor; Martin J Barron; Gillian M Borthwick; Amy Gospel; Patrick F Chinnery; David C Samuels; Geoffrey A Taylor; Stefan M Plusa; Stephanie J Needham; Laura C Greaves; Thomas B L Kirkwood; Douglass M Turnbull
Journal:  J Clin Invest       Date:  2003-11       Impact factor: 14.808

10.  Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging.

Authors:  Laila Ritsma; Saskia I J Ellenbroek; Anoek Zomer; Hugo J Snippert; Frederic J de Sauvage; Benjamin D Simons; Hans Clevers; Jacco van Rheenen
Journal:  Nature       Date:  2014-02-16       Impact factor: 49.962
  10 in total
  2 in total

1.  A Preliminary Study: Human Fibroid Stro-1+/CD44+ Stem Cells Isolated From Uterine Fibroids Demonstrate Decreased DNA Repair and Genomic Integrity Compared to Adjacent Myometrial Stro-1+/CD44+ Cells.

Authors:  Lauren E Prusinski Fernung; Ayman Al-Hendy; Qiwei Yang
Journal:  Reprod Sci       Date:  2018-06-28       Impact factor: 3.060

2.  The Hippo Pathway Effector YAP1 Regulates Intestinal Epithelial Cell Differentiation.

Authors:  Sepideh Fallah; Jean-François Beaulieu
Journal:  Cells       Date:  2020-08-13       Impact factor: 6.600
  2 in total

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