Literature DB >> 27308358

Awakening the Hippo co-activator YAP1, a mercurial cancer gene, in hematologic cancers.

Francesca Cottini1, Kenneth C Anderson2, Giovanni Tonon3.   

Abstract

Unrestrained oncogene activity triggers DNA damage. Cancer cells exploit various stratagems to deal with this potentially lethal event. We found that hematologic cancer cells inactivate the Hippo co-activator Yes-associated protein 1 (YAP1). A synthetic lethal approach is proposed whereby inhibition of the serine/threonine kinase 4 (STK4) could be exploited to restore YAP1 levels in hematologic cancers.

Entities:  

Keywords:  STK4; YAP-1; multiple myeloma; tumor suppressor

Year:  2014        PMID： 27308358      PMCID： PMC4904900          DOI： 10.4161/23723548.2014.970055

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  8 in total

1.  Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage.

Authors:  Dan Levy; Yaarit Adamovich; Nina Reuven; Yosef Shaul
Journal:  Mol Cell       Date:  2008-02-15       Impact factor: 17.970

2.  Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase.

Authors:  Z M Yuan; Y Huang; T Ishiko; S Kharbanda; R Weichselbaum; D Kufe
Journal:  Proc Natl Acad Sci U S A       Date:  1997-02-18       Impact factor: 11.205

Review 3.  Functional role for the c-Abl protein tyrosine kinase in the cellular response to genotoxic stress.

Authors:  S Kharbanda; Z M Yuan; R Weichselbaum; D Kufe
Journal:  Biochim Biophys Acta       Date:  1997-10-24

4.  Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance.

Authors:  Dawang Zhou; Yongyou Zhang; Hongtan Wu; Evan Barry; Yi Yin; Earl Lawrence; Dawn Dawson; Joseph E Willis; Sanford D Markowitz; Fernando D Camargo; Joseph Avruch
Journal:  Proc Natl Acad Sci U S A       Date:  2011-10-31       Impact factor: 11.205

5.  Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene.

Authors:  Dawang Zhou; Claudius Conrad; Fan Xia; Ji-Sun Park; Bernhard Payer; Yi Yin; Gregory Y Lauwers; Wolfgang Thasler; Jeannie T Lee; Joseph Avruch; Nabeel Bardeesy
Journal:  Cancer Cell       Date:  2009-11-06       Impact factor: 31.743

Review 6.  An oncogene-induced DNA damage model for cancer development.

Authors:  Thanos D Halazonetis; Vassilis G Gorgoulis; Jiri Bartek
Journal:  Science       Date:  2008-03-07       Impact factor: 47.728

7.  Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach.

Authors:  Lars Zender; Mona S Spector; Wen Xue; Peer Flemming; Carlos Cordon-Cardo; John Silke; Sheung-Tat Fan; John M Luk; Michael Wigler; Gregory J Hannon; David Mu; Robert Lucito; Scott Powers; Scott W Lowe
Journal:  Cell       Date:  2006-06-30       Impact factor: 41.582

8.  Rescue of Hippo coactivator YAP1 triggers DNA damage-induced apoptosis in hematological cancers.

Authors:  Francesca Cottini; Teru Hideshima; Chunxiao Xu; Martin Sattler; Martina Dori; Luca Agnelli; Elisa ten Hacken; Maria Teresa Bertilaccio; Elena Antonini; Antonino Neri; Maurilio Ponzoni; Magda Marcatti; Paul G Richardson; Ruben Carrasco; Alec C Kimmelman; Kwok-Kin Wong; Federico Caligaris-Cappio; Giovanni Blandino; W Michael Kuehl; Kenneth C Anderson; Giovanni Tonon
Journal:  Nat Med       Date:  2014-05-11       Impact factor: 53.440
  8 in total
  2 in total

Review 1.  YAP and the Hippo pathway in pediatric cancer.

Authors:  Atif A Ahmed; Abdalla D Mohamed; Melissa Gener; Weijie Li; Eugenio Taboada
Journal:  Mol Cell Oncol       Date:  2017-02-25

Review 2.  Germline Risk Contribution to Genomic Instability in Multiple Myeloma.

Authors:  Siegfried Janz; Fenghuang Zhan; Fumou Sun; Yan Cheng; Michael Pisano; Ye Yang; Hartmut Goldschmidt; Parameswaran Hari
Journal:  Front Genet       Date:  2019-05-08       Impact factor: 4.599
  2 in total

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