Literature DB >> 27308351

Functional characterization of ENPP1 reveals a link between cell cycle progression and stem-like phenotype in glioblastoma.

Josephine Bageritz1, Violaine Goidts2.   

Abstract

A high-throughput phenotypic screen in glioblastoma stem-like cells (GSCs) identified a novel molecular mechanism in which ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) plays an important role in balancing the pool of nucleotides, thus maintaining GSCs in an undifferentiated proliferative state. This finding highlights the connection between cell cycle length and the stem-like tumor state.

Entities:  

Keywords:  ENPP1; cell cycle; differentiation; glioblastoma stem-like cells; high-throughput screen; phosphatase

Year:  2014        PMID： 27308351      PMCID： PMC4905057          DOI： 10.4161/23723548.2014.964028

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  9 in total

1.  Differentiation therapy exerts antitumor effects on stem-like glioma cells.

Authors:  Benito Campos; Feng Wan; Mohammad Farhadi; Aurélie Ernst; Felix Zeppernick; Katrin E Tagscherer; Rezvan Ahmadi; Jennifer Lohr; Christine Dictus; Georg Gdynia; Stephanie E Combs; Violaine Goidts; Burkhard M Helmke; Volker Eckstein; Wilfried Roth; Philipp Beckhove; Peter Lichter; Andreas Unterberg; Bernhard Radlwimmer; Christel Herold-Mende
Journal:  Clin Cancer Res       Date:  2010-05-04       Impact factor: 12.531

2.  Glioma stem cells promote radioresistance by preferential activation of the DNA damage response.

Authors:  Shideng Bao; Qiulian Wu; Roger E McLendon; Yueling Hao; Qing Shi; Anita B Hjelmeland; Mark W Dewhirst; Darell D Bigner; Jeremy N Rich
Journal:  Nature       Date:  2006-10-18       Impact factor: 49.962

3.  Bone morphogenetic protein-7 release from endogenous neural precursor cells suppresses the tumourigenicity of stem-like glioblastoma cells.

Authors:  Sridhar Reddy Chirasani; Alexander Sternjak; Peter Wend; Stefan Momma; Benito Campos; Ilaria M Herrmann; Daniel Graf; Thimios Mitsiadis; Christel Herold-Mende; Daniel Besser; Michael Synowitz; Helmut Kettenmann; Rainer Glass
Journal:  Brain       Date:  2010-05-30       Impact factor: 13.501

4.  An RNAi screen identifies TRRAP as a regulator of brain tumor-initiating cell differentiation.

Authors:  Heiko Wurdak; Shoutian Zhu; Angelica Romero; Mihaela Lorger; James Watson; Chih-Yuan Chiang; Jay Zhang; Vanita S Natu; Luke L Lairson; John R Walker; Christopher M Trussell; Griffith R Harsh; Hannes Vogel; Brunhilde Felding-Habermann; Anthony P Orth; Loren J Miraglia; Daniel R Rines; Stephen L Skirboll; Peter G Schultz
Journal:  Cell Stem Cell       Date:  2010-01-08       Impact factor: 24.633

5.  Cdk4/cyclinD1 overexpression in neural stem cells shortens G1, delays neurogenesis, and promotes the generation and expansion of basal progenitors.

Authors:  Christian Lange; Wieland B Huttner; Federico Calegari
Journal:  Cell Stem Cell       Date:  2009-09-04       Impact factor: 24.633

6.  Stem cell characteristics in glioblastoma are maintained by the ecto-nucleotidase E-NPP1.

Authors:  J Bageritz; L Puccio; R M Piro; V Hovestadt; E Phillips; T Pankert; J Lohr; C Herold-Mende; P Lichter; V Goidts
Journal:  Cell Death Differ       Date:  2014-02-14       Impact factor: 15.828

7.  Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma.

Authors:  Gentao Liu; Xiangpeng Yuan; Zhaohui Zeng; Patrizia Tunici; Hiushan Ng; Iman R Abdulkadir; Lizhi Lu; Dwain Irvin; Keith L Black; John S Yu
Journal:  Mol Cancer       Date:  2006-12-02       Impact factor: 27.401

8.  The cell-cycle state of stem cells determines cell fate propensity.

Authors:  Siim Pauklin; Ludovic Vallier
Journal:  Cell       Date:  2013-09-26       Impact factor: 41.582

Review 9.  Nervous decision-making: to divide or differentiate.

Authors:  Laura J A Hardwick; Anna Philpott
Journal:  Trends Genet       Date:  2014-04-30       Impact factor: 11.639
  9 in total
  1 in total

1.  RNA sequencing reveals upregulation of a transcriptomic program associated with stemness in metastatic prostate cancer cells selected for taxane resistance.

Authors:  Christina K Cajigas-Du Ross; Shannalee R Martinez; Leanne Woods-Burnham; Alfonso M Durán; Sourav Roy; Anamika Basu; Joshua A Ramirez; Greisha L Ortiz-Hernández; Leslimar Ríos-Colón; Evgeny Chirshev; Evelyn S Sanchez-Hernandez; Ubaldo Soto; Celine Greco; Claude Boucheix; Xin Chen; Juli Unternaehrer; Charles Wang; Carlos A Casiano
Journal:  Oncotarget       Date:  2018-07-13
  1 in total

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