Literature DB >> 27306760

Expression Profiling of DNA Methylation and Transcriptional Repression Associated Genes in Lens Epithelium Cells of Age-Related Cataract.

Yong Wang1, Guowei Zhang1, Lihua Kang1, Huaijin Guan2.   

Abstract

In our previous research, the formation and development of age-related cataract (ARC) is associated with DNA hypermethylation of some genes in lens epithelial cells (LECs). This study aimed to investigate the expression profile of DNA methylation- and transcriptional repression-associated genes in LECs of ARC. The expression levels of the genes were first evaluated by microarray analysis. The results were further confirmed by Quantitative Real-Time PCR (qRT-PCR) and Western blot assay. The mRNA and protein levels of 5 genes increased in LECs of ARCs compared with the controls. These data provided a global perspective on expression of DNA methylation- and transcriptional repression-associated genes. The study supports the notion that the epigenetic modification of macromolecules in LECs might contribute to ARC pathogenesis.

Entities:  

Keywords:  Age-related cataract; DNA methylation; Epigenetics; Lens epithelial cells; mRNA array

Mesh：

Substances：

Year:  2016        PMID： 27306760     DOI： 10.1007/s10571-016-0393-9

Source DB:  PubMed          Journal:  Cell Mol Neurobiol        ISSN： 0272-4340            Impact factor:   5.046


  42 in total

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Authors:  Xiang-Jia Zhu; Ke-Ke Zhang; Peng Zhou; Chun-Hui Jiang; Yi Lu
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2015-02-10       Impact factor: 3.117

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Journal:  J Biol Chem       Date:  2005-01-04       Impact factor: 5.157

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Journal:  Dev Biol       Date:  2002-05-15       Impact factor: 3.582

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Authors:  Peng Zhou; Yi Luo; Xin Liu; Lei Fan; Yi Lu
Journal:  FASEB J       Date:  2012-08-13       Impact factor: 5.191

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  8 in total

Review 1.  The Role of DNA Methylation in Lens Development and Cataract Formation.

Authors:  Yong Wang; Huaijin Guan
Journal:  Cell Mol Neurobiol       Date:  2016-11-18       Impact factor: 5.046

Review 2.  Epigenetic regulation of anterior segment diseases and potential therapeutics.

Authors:  Eric Chen; Kelley Bohm; Mark Rosenblatt; Kai Kang
Journal:  Ocul Surf       Date:  2020-04-25       Impact factor: 5.033

3.  MicroRNA-30a Regulation of Epithelial-Mesenchymal Transition in Diabetic Cataracts Through Targeting SNAI1.

Authors:  Lu Zhang; Ye Wang; Wenfeng Li; Panagiotis A Tsonis; Zhiyuan Li; Lixin Xie; Yusen Huang
Journal:  Sci Rep       Date:  2017-04-25       Impact factor: 4.379

4.  Effects of Inhibitors on the Transcriptional Profiling of Gluconobater oxydans NL71 Genes after Biooxidation of Xylose into Xylonate.

Authors:  Yuanyuan Miao; Yi Shen; Yong Xu
Journal:  Front Microbiol       Date:  2017-04-25       Impact factor: 5.640

5.  microRNA-199a-5p regulates epithelial-to-mesenchymal transition in diabetic cataract by targeting SP1 gene.

Authors:  Xin Liu; Qiaoyun Gong; Longfei Yang; Min Liu; Lingzhi Niu; Lufei Wang
Journal:  Mol Med       Date:  2020-12-04       Impact factor: 6.354

6.  lncRNA XIST knockdown suppresses cell proliferation and promotes apoptosis in diabetic cataracts through the miR‑34a/SMAD2 axis.

Authors:  Chao Wang; Ruiling Zhao; Suhong Zhang
Journal:  Mol Med Rep       Date:  2021-11-09       Impact factor: 2.952

7.  The aging mouse lens transcriptome.

Authors:  Adam P Faranda; Mahbubul H Shihan; Yan Wang; Melinda K Duncan
Journal:  Exp Eye Res       Date:  2021-06-11       Impact factor: 3.770

8.  Identification and Characterization of N6-Methyladenosine CircRNAs and Methyltransferases in the Lens Epithelium Cells From Age-Related Cataract.

Authors:  Pengfei Li; Hualin Yu; Guowei Zhang; Lihua Kang; Bai Qin; Yu Cao; Jiawei Luo; Xiaojuan Chen; Ying Wang; Miaomiao Qin; Jian Wu; Yemeng Huang; Xi Zou; Huaijin Guan; Yong Wang
Journal:  Invest Ophthalmol Vis Sci       Date:  2020-08-03       Impact factor: 4.799
  8 in total

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