Literature DB >> 2730642

Mechanisms of reoxygenation injury in myocardial infarction: implications of a myoglobin redox cycle.

D Galaris1, L Eddy, A Arduini, E Cadenas, P Hochstein.   

Abstract

The addition of ascorbate to ischemic rat hearts prevents the myocardial damage associated with reoxygenation. H2O2 oxidizes myoglobin (Mb+2) to higher oxidation states (Mb+4 and Mb+5) which are rapidly reduced by ascorbate. It is proposed that the operation of a myoglobin redox cycle, in which H2O2 causes the two-electron oxidation of myoglobin, is a critical determinant of reperfusion injury. Conversely, the reduction of myoglobin, in one-electron steps, may represent an essential protective mechanism against such injury in the heart.

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Year:  1989        PMID： 2730642     DOI： 10.1016/s0006-291x(89)80125-1

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  12 in total

1.  Effects of phytic acid on the myoglobin-t-butylhydroperoxide-catalysed oxidation of uric acid and peroxidation of erythrocyte membrane lipids.

Authors:  K M Ko; D V Godin
Journal:  Mol Cell Biochem       Date:  1991-02-27       Impact factor: 3.396

2.  Hydrogen peroxide-mediated alteration of the heme prosthetic group of metmyoglobin to an iron chlorin product: evidence for a novel oxidative pathway.

Authors:  K Sugiyama; R J Highet; A Woods; R J Cotter; Y Osawa
Journal:  Proc Natl Acad Sci U S A       Date:  1997-02-04       Impact factor: 11.205

3.  Ascorbate removes key precursors to oxidative damage by cell-free haemoglobin in vitro and in vivo.

Authors:  Jacqueline Dunne; Alexis Caron; Patrick Menu; Abdu I Alayash; Paul W Buehler; Michael T Wilson; Radu Silaghi-Dumitrescu; Beatrice Faivre; Chris E Cooper
Journal:  Biochem J       Date:  2006-11-01       Impact factor: 3.857

4.  Hypoxia/reoxygenation impairs memory formation via adenosine-dependent activation of caspase 1.

Authors:  Gabriel S Chiu; Diptaman Chatterjee; Patrick T Darmody; John P Walsh; Daryl D Meling; Rodney W Johnson; Gregory G Freund
Journal:  J Neurosci       Date:  2012-10-03       Impact factor: 6.167

5.  Relationship between myoglobin contents and increases in cyclic GMP produced by glyceryl trinitrate and nitric oxide in rabbit aorta, right atrium and papillary muscle.

Authors:  T Ishibashi; M Hamaguchi; K Kato; T Kawada; H Ohta; H Sasage; S Imai
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-05       Impact factor: 3.000

6.  Flavin reductase: sequence of cDNA from bovine liver and tissue distribution.

Authors:  K S Quandt; D E Hultquist
Journal:  Proc Natl Acad Sci U S A       Date:  1994-09-27       Impact factor: 11.205

7.  Nitrite reductase activity of myoglobin regulates respiration and cellular viability in myocardial ischemia-reperfusion injury.

Authors:  Ulrike B Hendgen-Cotta; Marc W Merx; Sruti Shiva; Joel Schmitz; Stefanie Becher; Johann P Klare; Heinz-Jürgen Steinhoff; Axel Goedecke; Jürgen Schrader; Mark T Gladwin; Malte Kelm; Tienush Rassaf
Journal:  Proc Natl Acad Sci U S A       Date:  2008-07-16       Impact factor: 11.205

8.  Antioxidant effect of coenzyme Q on hydrogen peroxide-activated myoglobin.

Authors:  A Mordente; G E Martorana; S A Santini; G A Miggiano; T Petitti; B Giardina; M Battino; G P Littarru
Journal:  Clin Investig       Date:  1993

9.  Regio- and stereo-chemical oxidation of linoleic acid by human myoglobin and hydrogen peroxide: Tyr(103) affects rate and product distribution.

Authors:  Benjamin S Rayner; Roland Stocker; Peter A Lay; Paul K Witting
Journal:  Biochem J       Date:  2004-07-15       Impact factor: 3.857

10.  One-electron oxidation of ergothioneine and analogues investigated by pulse radiolysis: redox reaction involving ergothioneine and vitamin C.

Authors:  K D Asmus; R V Bensasson; J L Bernier; R Houssin; E J Land
Journal:  Biochem J       Date:  1996-04-15       Impact factor: 3.857
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