| Literature DB >> 27306030 |
Béranger Lueza1,2,3, Federico Rotolo4,5,6, Julia Bonastre1,2, Jean-Pierre Pignon1,2,3, Stefan Michiels1,2,3.
Abstract
Entities:
Year: 2016 PMID: 27306030 PMCID: PMC4910251 DOI: 10.1186/s12874-016-0154-y
Source DB: PubMed Journal: BMC Med Res Methodol ISSN: 1471-2288 Impact factor: 4.615
Results for comparisons of methods in estimating the difference in restricted mean survival time (rmstD) in MAC-NPC and MAC-NPC2 meta-analyses
| Meta-analysis model | Methods | MAC-NPC | MAC-NPC2 | ||||||||||
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| Naïve Kaplan-Meier | 0.20 | 0.08 | 0.008 | 0.51 | 0.19 | 0.006 | 0.17 | 0.04 | <0.001 | 0.54 | 0.11 | <0.001 | |
| Random effects | Pooled Kaplan-Meier | 0.17 | 0.11 | 0.106 | 0.49 | 0.28 | 0.081 | 0.20 | 0.05 | <0.001 | 0.59 | 0.13 | <0.001 |
| Pooled Exponential | 0.17 | 0.09 | 0.076 | 0.51 | 0.29 | 0.078 | 0.17 | 0.03 | <0.001 | 0.55 | 0.11 | <0.001 | |
| Peto-quintile | 0.23 | 0.09 | 0.007 | 0.55 | 0.22 | 0.011 | 0.21 | 0.04 | <0.001 | 0.59 | 0.12 | <0.001 | |
| Fixed effect | Pooled Kaplan-Meier | 0.20 | 0.07 | 0.005 | 0.52 | 0.18 | 0.004 | 0.18 | 0.04 | <0.001 | 0.59 | 0.10 | <0.001 |
| Pooled Exponential | 0.18 | 0.06 | 0.003 | 0.55 | 0.18 | 0.002 | 0.17 | 0.03 | <0.001 | 0.56 | 0.09 | <0.001 | |
| Peto-quintile | 0.20 | 0.07 | 0.006 | 0.46 | 0.16 | 0.004 | 0.18 | 0.04 | <0.001 | 0.53 | 0.09 | <0.001 | |
MAC-NPC Meta-Analysis of Chemotherapy in Nasopharynx Carcinoma, rmstD difference in restricted mean survival time, SE standard error, t time horizon
Fig. 3Forest plot for differences in restricted mean survival time estimated at 10 years using the Pooled Kaplan-Meier method with random effects applied to the MAC-NPC meta-analysis. Each trial is represented by a square, the center of which denotes the difference in restricted mean survival time (rmstD) for that trial comparison, with the horizontal lines showing the 95 % confidence intervals (CI). The size of the square is directly proportional to the amount of information contributed by the trial. The diamond represents the overall rmstD, with the center denoting the rmstD and the extremities the 95 % CI. The rmstDs are expressed in year