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Literature DB >> 2730574

Oxidation of 5-methyltetrahydrofolate in cobalamin-inactivated rats.

Abstract

Rats were exposed to nitrous oxide, which inactivates cob(I)alamin (Cbl). As in air-breathing rats methionine administration led to the conversion of hepatic 5-methyltetrahydrofolate (MeH4 folate) into formyltetrahydrofolate. The recovery of MeH4 folate levels in liver after its oxidation initiated by methionine was noted and the rate compared with that for air-breathing rats. Oxidation of MeH4 folate was less complete and occurred more slowly in Cbl-inactivated rats as compared with controls. However, recovery of MeH4 folate levels was more rapid in Cbl inactivation. S-Adenosylmethionine did not produce a significant change in MeH4 folate levels in Cbl-inactivated rats, whereas it did so in air-breathing animals.

Entities: Chemical Species

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Year: 1989 PMID： 2730574 PMCID： PMC1138450 DOI： 10.1042/bj2580907

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

11 in total

1. 5-Methyltetrahydrofolate aromatic alkylamine N-methyltransferase: an artefact of 5,10-methylenetetrahydrofolate reductase activity.

Authors: R T Taylor; M L Hanna
Journal: Life Sci Date: 1975-07-01 Impact factor: 5.037

2. Folate-dependent 1-carbon transfer to biogenic amines mediated by methylenetetrahydrofolate reductase.

Authors: A G Pearson; A J Turner
Journal: Nature Date: 1975-11-13 Impact factor: 49.962

3. Interrelations of vitamin B12 and folic acid metabolism: folic acid clearance studies.

Authors: V HERBERT; R ZALUSKY
Journal: J Clin Invest Date: 1962-06 Impact factor: 14.808

4. Examination of the role of methylenetetrahydrofolate reductase in incorporation of methyltetrahydrofolate into cellular metabolism.

Authors: J M Green; D P Ballou; R G Matthews
Journal: FASEB J Date: 1988-01 Impact factor: 5.191

5. Mammalian methylenetetrahydrofolate reductase. Partial purification, properties, and inhibition by S-adenosylmethionine.

Authors: C Kutzbach; E L Stokstad
Journal: Biochim Biophys Acta Date: 1971-12-15

1. A weak link in metabolism: the metabolic capacity for glycine biosynthesis does not satisfy the need for collagen synthesis.

Authors: Enrique Meléndez-Hevia; Patricia De Paz-Lugo; Athel Cornish-Bowden; María Luz Cárdenas
Journal: J Biosci Date: 2009-12 Impact factor: 1.826

2. Effect of nitrous oxide on nickel deprivation in rats.

Authors: E O Uthus; R A Poellot
Journal: Biol Trace Elem Res Date: 1993-07 Impact factor: 3.738

2 in total

Oxidation of 5-methyltetrahydrofolate in cobalamin-inactivated rats.

1. 5-Methyltetrahydrofolate aromatic alkylamine N-methyltransferase: an artefact of 5,10-methylenetetrahydrofolate reductase activity.

2. Folate-dependent 1-carbon transfer to biogenic amines mediated by methylenetetrahydrofolate reductase.

3. Interrelations of vitamin B12 and folic acid metabolism: folic acid clearance studies.

4. Examination of the role of methylenetetrahydrofolate reductase in incorporation of methyltetrahydrofolate into cellular metabolism.

5. Mammalian methylenetetrahydrofolate reductase. Partial purification, properties, and inhibition by S-adenosylmethionine.

6. Selective inactivation of vitamin B12 in rats by nitrous oxide.

7. Turnover of the methyl moiety of 5-methyltetrahydropteroylglutamic acid in the cobalamin-inactivated rat.

8. Chronic cobalamin inactivation impairs folate polyglutamate synthesis in the rat.

9. In vivo oxidation of the methyl group of hepatic 5-methyltetrahydrofolate.

10. Folate pentaglutamate and folate hexaglutamate mediated one-carbon metabolism.

1. A weak link in metabolism: the metabolic capacity for glycine biosynthesis does not satisfy the need for collagen synthesis.

2. Effect of nitrous oxide on nickel deprivation in rats.