Literature DB >> 2730527

Sarcolemmal integrity during ischaemia and reperfusion of the isolated rat heart.

I S Harper1, A Lochner.   

Abstract

The effects of ischaemia and reperfusion on sarcolemmal permeability were studied in the isolated rat heart using an ionic lanthanum probe technique. Detection of increased permeability after exposure to short periods of ischaemia without accompanying reperfusion effects was achieved by employing a substrate-free, low calcium saline solution as vehicle for ionic lanthanum. Quantifiable results showed a rapid increase in sarcolemmal permeability in the subendocardium after 15 min of ischaemia, with the subepicardium showing similar alterations after longer periods. Reperfusion after 15 min of ischaemia led to recovery of normal permeability characteristics, correlating well with ultrastructural and functional recovery. Reperfusion after 25 min of ischaemia did not allow recovery of sarcolemmal permeability, ultrastructure, or function. These results show a clear correlation between the development of irreversible myocardial damage and increased sarcolemmal membrane permeability.

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Year:  1989        PMID： 2730527     DOI： 10.1007/bf01907930

Source DB:  PubMed          Journal:  Basic Res Cardiol        ISSN： 0300-8428            Impact factor:   17.165


  38 in total

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Journal:  Circ Res       Date:  1985-12       Impact factor: 17.367

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Journal:  Am J Pathol       Date:  1978-02       Impact factor: 4.307

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Journal:  Am J Pathol       Date:  1977-04       Impact factor: 4.307
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  7 in total

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Authors:  A Lochner; S Genade; R Mouton
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Authors:  T A Schmidt; J H Svendsen; S Haunsø; K Kjeldsen
Journal:  Basic Res Cardiol       Date:  1990 Jul-Aug       Impact factor: 17.165

3.  Substrate effects on sarcolemmal permeability in the normoxic and hypoxic perfused rat heart.

Authors:  A Lochner; A Pentz; K Williams; E Tromp; I S Harper
Journal:  Basic Res Cardiol       Date:  1996 Jan-Feb       Impact factor: 17.165

4.  Uncoupling of increased cellular oxidative stress and myocardial ischemia reperfusion injury by directed sarcolemma stabilization.

Authors:  Joshua J Martindale; Joseph M Metzger
Journal:  J Mol Cell Cardiol       Date:  2013-12-19       Impact factor: 5.000

5.  Ultrastructural correlates of ischaemic contracture during global subtotal ischaemia in the rat heart.

Authors:  I S Harper; E van der Merwe; P Owen; L H Opie
Journal:  J Exp Pathol (Oxford)       Date:  1990-04

6.  Disruption of sarcolemmal integrity during ischemia and reperfusion of canine hearts as monitored by use of lathanum ions and a specific probe.

Authors:  S Koba; N Konno; H Suzuki; T Katagiri
Journal:  Basic Res Cardiol       Date:  1995 May-Jun       Impact factor: 17.165

7.  Effects of beta-blockers and Ca(2+)-antagonists on the response of the isolated working rat heart to adrenergic stimulants after cardioplegic arrest.

Authors:  P Hattingh; A Coetzee; I Harper; S Genade; A Lochner
Journal:  Cardiovasc Drugs Ther       Date:  1993-12       Impact factor: 3.727
  7 in total

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