| Literature DB >> 27304608 |
L H Pecker1,2,3, A Timsar3,4, P P Pary1, G A Denomme5, V R Criss1, N L C Luban1,2,3,4, E I Hwang1,2,3, E C C Wong1,2,3,4.
Abstract
Ceftriaxone-induced immune hemolytic anemia (CIHA) is the second most common cause of drug-induced hemolytic anemia. Prompt recognition of this drug reaction is essential because brisk hemolysis can be deadly. The extent to which ceftriaxone antibodies persist after CIHA is unknown; rechallenging patients who have experienced CIHA is not recommended. We report a case of CIHA in a neurooncology patient, which is the first to show anticeftriaxone antibodies with Rh specificity and persisted for 8 months after the drug reaction. These findings have implications for understanding the mechanism of CIHA.Entities:
Keywords: anemias; blood bank; immune cytopenias; transfusion medicine
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Year: 2016 PMID： 27304608 DOI： 10.1002/pbc.26101
Source DB: PubMed Journal: Pediatr Blood Cancer ISSN： 1545-5009 Impact factor: 3.167