Literature DB >> 27304507

Metformin as a Tool to Target Aging.

Nir Barzilai1, Jill P Crandall2, Stephen B Kritchevsky3, Mark A Espeland3.   

Abstract

Aging has been targeted by genetic and dietary manipulation and by drugs in order to increase lifespan and health span in numerous models. Metformin, which has demonstrated protective effects against several age-related diseases in humans, will be tested in the TAME (Targeting Aging with Metformin) trial, as the initial step in the development of increasingly effective next-generation drugs.
Copyright © 2016. Published by Elsevier Inc.

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Year:  2016        PMID： 27304507      PMCID： PMC5943638          DOI： 10.1016/j.cmet.2016.05.011

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  79 in total

1.  Diabetes, metformin use, and colon cancer: a population-based cohort study in Taiwan.

Authors:  Chin-Hsiao Tseng
Journal:  Eur J Endocrinol       Date:  2012-07-09       Impact factor: 6.664

2.  Prolonged metformin treatment leads to reduced transcription of Nrf2 and neurotrophic factors without cognitive impairment in older C57BL/6J mice.

Authors:  Joanne S Allard; Evelyn J Perez; Koji Fukui; Priscilla Carpenter; Donald K Ingram; Rafael de Cabo
Journal:  Behav Brain Res       Date:  2015-12-14       Impact factor: 3.332

Review 3.  Antidiabetic drugs and their potential role in treating mild cognitive impairment and Alzheimer's disease.

Authors:  Kannayiram Alagiakrishnan; Sowndramalingam Sankaralingam; Mahua Ghosh; Laurie Mereu; Peter Senior
Journal:  Discov Med       Date:  2013-12       Impact factor: 2.970

4.  Potent anti-proliferative effects of metformin on trastuzumab-resistant breast cancer cells via inhibition of erbB2/IGF-1 receptor interactions.

Authors:  Bolin Liu; Zeying Fan; Susan M Edgerton; XiaoHe Yang; Stuart E Lind; Ann D Thor
Journal:  Cell Cycle       Date:  2011-09-01       Impact factor: 4.534

Review 5.  Metformin: from mechanisms of action to therapies.

Authors:  Marc Foretz; Bruno Guigas; Luc Bertrand; Michael Pollak; Benoit Viollet
Journal:  Cell Metab       Date:  2014-10-30       Impact factor: 27.287

6.  Metformin decreases IGF1-induced cell proliferation and protein synthesis through AMP-activated protein kinase in cultured bovine granulosa cells.

Authors:  Lucie Tosca; Christelle Ramé; Christine Chabrolle; Sophie Tesseraud; Joëlle Dupont
Journal:  Reproduction       Date:  2009-11-11       Impact factor: 3.906

7.  Metformin and cancer occurrence in insulin-treated type 2 diabetic patients.

Authors:  Matteo Monami; Claudia Colombi; Daniela Balzi; Ilaria Dicembrini; Stefano Giannini; Cecilia Melani; Valentina Vitale; Desiderio Romano; Alessandro Barchielli; Niccolò Marchionni; Carlo Maria Rotella; Edoardo Mannucci
Journal:  Diabetes Care       Date:  2010-10-27       Impact factor: 19.112

8.  If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice.

Authors:  Vladimir N Anisimov; Lev M Berstein; Irina G Popovich; Mark A Zabezhinski; Peter A Egormin; Tatiana S Piskunova; Anna V Semenchenko; Margarita L Tyndyk; Maria N Yurova; Irina G Kovalenko; Tatiana E Poroshina
Journal:  Aging (Albany NY)       Date:  2011-02       Impact factor: 5.682

9.  Improvement of cardiac functions by chronic metformin treatment is associated with enhanced cardiac autophagy in diabetic OVE26 mice.

Authors:  Zhonglin Xie; Kai Lau; Bonnie Eby; Pedro Lozano; Chaoyong He; Becky Pennington; Hongliang Li; Shradha Rathi; Yunzhou Dong; Rong Tian; David Kem; Ming-Hui Zou
Journal:  Diabetes       Date:  2011-05-11       Impact factor: 9.461

10.  Metformin-mediated growth inhibition involves suppression of the IGF-I receptor signalling pathway in human pancreatic cancer cells.

Authors:  Emelie Karnevi; Katarzyna Said; Roland Andersson; Ann H Rosendahl
Journal:  BMC Cancer       Date:  2013-05-10       Impact factor: 4.430
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  300 in total

1.  Metformin: historical overview.

Authors:  Clifford J Bailey
Journal:  Diabetologia       Date:  2017-08-03       Impact factor: 10.122

2.  Impact of an 8-Year Intensive Lifestyle Intervention on an Index of Multimorbidity.

Authors:  Mark A Espeland; Sarah A Gaussoin; Judy Bahnson; Elizabeth M Vaughan; William C Knowler; Felicia R Simpson; Helen P Hazuda; Karen C Johnson; Medha N Munshi; Mace Coday; Xavier Pi-Sunyer
Journal:  J Am Geriatr Soc       Date:  2020-07-17       Impact factor: 5.562

Review 3.  Genetics of extreme human longevity to guide drug discovery for healthy ageing.

Authors:  Zhengdong D Zhang; Sofiya Milman; Jhih-Rong Lin; Shayne Wierbowski; Haiyuan Yu; Nir Barzilai; Vera Gorbunova; Warren C Ladiges; Laura J Niedernhofer; Yousin Suh; Paul D Robbins; Jan Vijg
Journal:  Nat Metab       Date:  2020-07-27

4.  Oral Azelaic Acid Ester Decreases Markers of Insulin Resistance in Overweight Human Male Subjects.

Authors:  Robert T Streeper; Elzbieta Izbicka; Christopher Louden
Journal:  In Vivo       Date:  2020 May-Jun       Impact factor: 2.155

Review 5.  Senescent cells: an emerging target for diseases of ageing.

Authors:  Bennett G Childs; Martina Gluscevic; Darren J Baker; Remi-Martin Laberge; Dan Marquess; Jamie Dananberg; Jan M van Deursen
Journal:  Nat Rev Drug Discov       Date:  2017-07-21       Impact factor: 84.694

6.  Techniques to Induce and Quantify Cellular Senescence.

Authors:  Nicole Noren Hooten; Michele K Evans
Journal:  J Vis Exp       Date:  2017-05-01       Impact factor: 1.355

7.  Metformin as targeted treatment in fragile X syndrome.

Authors:  A B C Dy; F Tassone; M Eldeeb; M J Salcedo-Arellano; N Tartaglia; R Hagerman
Journal:  Clin Genet       Date:  2017-09-25       Impact factor: 4.438

Review 8.  WRN Mutation Update: Mutation Spectrum, Patient Registries, and Translational Prospects.

Authors:  Koutaro Yokote; Sirisak Chanprasert; Lin Lee; Katharina Eirich; Minoru Takemoto; Aki Watanabe; Naoko Koizumi; Davor Lessel; Takayasu Mori; Fuki M Hisama; Paula D Ladd; Brad Angle; Hagit Baris; Kivanc Cefle; Sukru Palanduz; Sukru Ozturk; Antoinette Chateau; Kentaro Deguchi; T K M Easwar; Antonio Federico; Amy Fox; Theresa A Grebe; Beverly Hay; Sheela Nampoothiri; Karen Seiter; Elizabeth Streeten; Raul E Piña-Aguilar; Gemma Poke; Martin Poot; Renata Posmyk; George M Martin; Christian Kubisch; Detlev Schindler; Junko Oshima
Journal:  Hum Mutat       Date:  2016-10-07       Impact factor: 4.878

Review 9.  Mechanisms of Vascular Aging.

Authors:  Zoltan Ungvari; Stefano Tarantini; Anthony J Donato; Veronica Galvan; Anna Csiszar
Journal:  Circ Res       Date:  2018-09-14       Impact factor: 17.367

Review 10.  Multimorbidity and functional impairment-bidirectional interplay, synergistic effects and common pathways.

Authors:  A Calderón-Larrañaga; D L Vetrano; L Ferrucci; S W Mercer; A Marengoni; G Onder; M Eriksdotter; L Fratiglioni
Journal:  J Intern Med       Date:  2018-11-22       Impact factor: 8.989
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