Literature DB >> 27304496

Why NAD(+) Declines during Aging: It's Destroyed.

Michael B Schultz1, David A Sinclair2.   

Abstract

NAD(+) is required not only for life but for a long life. In this issue, Camacho-Pereira et al. (2016) implicate CD38 in the decline of NAD(+) during aging, with implications for combating age-related diseases.
Copyright © 2016 Elsevier Inc. All rights reserved.

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Year:  2016        PMID： 27304496      PMCID： PMC5088772          DOI： 10.1016/j.cmet.2016.05.022

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  10 in total

1.  Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice.

Authors:  Jun Yoshino; Kathryn F Mills; Myeong Jin Yoon; Shin-ichiro Imai
Journal:  Cell Metab       Date:  2011-10-05       Impact factor: 27.287

2.  Discovery, Synthesis, and Biological Evaluation of Thiazoloquin(az)olin(on)es as Potent CD38 Inhibitors.

Authors:  Curt D Haffner; J David Becherer; Eric E Boros; Rodolfo Cadilla; Tiffany Carpenter; David Cowan; David N Deaton; Yu Guo; Wallace Harrington; Brad R Henke; Michael R Jeune; Istvan Kaldor; Naphtali Milliken; Kim G Petrov; Frank Preugschat; Christie Schulte; Barry G Shearer; Todd Shearer; Terrence L Smalley; Eugene L Stewart; J Darren Stuart; John C Ulrich
Journal:  J Med Chem       Date:  2015-04-10       Impact factor: 7.446

3.  Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels.

Authors:  Rozalyn M Anderson; Kevin J Bitterman; Jason G Wood; Oliver Medvedik; Haim Cohen; Stephen S Lin; Jill K Manchester; Jeffrey I Gordon; David A Sinclair
Journal:  J Biol Chem       Date:  2002-03-07       Impact factor: 5.157

4.  CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism.

Authors:  Juliana Camacho-Pereira; Mariana G Tarragó; Claudia C S Chini; Veronica Nin; Carlos Escande; Gina M Warner; Amrutesh S Puranik; Renee A Schoon; Joel M Reid; Antonio Galina; Eduardo N Chini
Journal:  Cell Metab       Date:  2016-06-14       Impact factor: 27.287

5.  Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging.

Authors:  Ana P Gomes; Nathan L Price; Alvin J Y Ling; Javid J Moslehi; Magdalene K Montgomery; Luis Rajman; James P White; João S Teodoro; Christiane D Wrann; Basil P Hubbard; Evi M Mercken; Carlos M Palmeira; Rafael de Cabo; Anabela P Rolo; Nigel Turner; Eric L Bell; David A Sinclair
Journal:  Cell       Date:  2013-12-19       Impact factor: 41.582

6.  NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice.

Authors:  Hongbo Zhang; Dongryeol Ryu; Yibo Wu; Karim Gariani; Xu Wang; Peiling Luan; Davide D'Amico; Eduardo R Ropelle; Matthias P Lutolf; Ruedi Aebersold; Kristina Schoonjans; Keir J Menzies; Johan Auwerx
Journal:  Science       Date:  2016-04-28       Impact factor: 47.728

7.  Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival.

Authors:  Hongying Yang; Tianle Yang; Joseph A Baur; Evelyn Perez; Takashi Matsui; Juan J Carmona; Dudley W Lamming; Nadja C Souza-Pinto; Vilhelm A Bohr; Anthony Rosenzweig; Rafael de Cabo; Anthony A Sauve; David A Sinclair
Journal:  Cell       Date:  2007-09-21       Impact factor: 41.582

8.  PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation.

Authors:  Péter Bai; Carles Cantó; Hugues Oudart; Attila Brunyánszki; Yana Cen; Charles Thomas; Hiroyasu Yamamoto; Aline Huber; Borbála Kiss; Riekelt H Houtkooper; Kristina Schoonjans; Valérie Schreiber; Anthony A Sauve; Josiane Menissier-de Murcia; Johan Auwerx
Journal:  Cell Metab       Date:  2011-04-06       Impact factor: 27.287

9.  Regulation of the cd38 promoter in human airway smooth muscle cells by TNF-alpha and dexamethasone.

Authors:  Krishnaswamy G Tirumurugaan; Bit Na Kang; Reynold A Panettieri; Douglas N Foster; Timothy F Walseth; Mathur S Kannan
Journal:  Respir Res       Date:  2008-03-14

10.  Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome.

Authors:  Carlos Escande; Veronica Nin; Nathan L Price; Verena Capellini; Ana P Gomes; Maria Thereza Barbosa; Luke O'Neil; Thomas A White; David A Sinclair; Eduardo N Chini
Journal:  Diabetes       Date:  2012-11-19       Impact factor: 9.461
  10 in total
  54 in total

Review 1.  Nicotinamide riboside-A missing piece in the puzzle of exercise therapy for older adults?

Authors:  Carlo Custodero; Sunil K Saini; Myung J Shin; Yun K Jeon; Demetra D Christou; Mary M McDermott; Christiaan Leeuwenburgh; Stephen D Anton; Robert T Mankowski
Journal:  Exp Gerontol       Date:  2020-05-22       Impact factor: 4.032

2.  The Science Behind NMN-A Stable, Reliable NAD+Activator and Anti-Aging Molecule.

Authors:  Christopher Shade
Journal:  Integr Med (Encinitas)       Date:  2020-02

3.  Aging alters acetylation status in skeletal and cardiac muscles.

Authors:  Dongwook Yeo; Chounghun Kang; Li Li Ji
Journal:  Geroscience       Date:  2020-04-16       Impact factor: 7.713

4.  Nicotinamide mononucleotide (NMN) treatment attenuates oxidative stress and rescues angiogenic capacity in aged cerebromicrovascular endothelial cells: a potential mechanism for the prevention of vascular cognitive impairment.

Authors:  Tamas Kiss; Priya Balasubramanian; Marta Noa Valcarcel-Ares; Stefano Tarantini; Andriy Yabluchanskiy; Tamas Csipo; Agnes Lipecz; Dora Reglodi; Xin A Zhang; Ferenc Bari; Eszter Farkas; Anna Csiszar; Zoltan Ungvari
Journal:  Geroscience       Date:  2019-05-29       Impact factor: 7.713

Review 5.  Role of endothelial NAD+ deficiency in age-related vascular dysfunction.

Authors:  Anna Csiszar; Stefano Tarantini; Andriy Yabluchanskiy; Priya Balasubramanian; Tamas Kiss; Eszter Farkas; Joseph A Baur; Zoltan Ungvari
Journal:  Am J Physiol Heart Circ Physiol       Date:  2019-03-15       Impact factor: 4.733

Review 6.  The CD38 glycohydrolase and the NAD sink: implications for pathological conditions.

Authors:  Julianna D Zeidler; Kelly A Hogan; Guillermo Agorrody; Thais R Peclat; Sonu Kashyap; Karina S Kanamori; Lilian Sales Gomez; Delaram Z Mazdeh; Gina M Warner; Katie L Thompson; Claudia C S Chini; Eduardo Nunes Chini
Journal:  Am J Physiol Cell Physiol       Date:  2022-02-09       Impact factor: 4.249

7.  Treatment with the poly(ADP-ribose) polymerase inhibitor PJ-34 improves cerebromicrovascular endothelial function, neurovascular coupling responses and cognitive performance in aged mice, supporting the NAD+ depletion hypothesis of neurovascular aging.

Authors:  Stefano Tarantini; Andriy Yabluchanskiy; Tamas Csipo; Gabor Fulop; Tamas Kiss; Priya Balasubramanian; Jordan DelFavero; Chetan Ahire; Anna Ungvari; Ádám Nyúl-Tóth; Eszter Farkas; Zoltan Benyo; Attila Tóth; Anna Csiszar; Zoltan Ungvari
Journal:  Geroscience       Date:  2019-11-02       Impact factor: 7.713

Review 8.  The Pharmacology of CD38/NADase: An Emerging Target in Cancer and Diseases of Aging.

Authors:  Eduardo N Chini; Claudia C S Chini; Jair Machado Espindola Netto; Guilherme C de Oliveira; Wim van Schooten
Journal:  Trends Pharmacol Sci       Date:  2018-02-23       Impact factor: 14.819

Review 9.  Biological Properties of Vitamins of the B-Complex, Part 1: Vitamins B1, B2, B3, and B5.

Authors:  Marcel Hrubša; Tomáš Siatka; Iveta Nejmanová; Marie Vopršalová; Lenka Kujovská Krčmová; Kateřina Matoušová; Lenka Javorská; Kateřina Macáková; Laura Mercolini; Fernando Remião; Marek Máťuš; Přemysl Mladěnka
Journal:  Nutrients       Date:  2022-01-22       Impact factor: 5.717

10.  A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline.

Authors:  Mariana G Tarragó; Claudia C S Chini; Karina S Kanamori; Gina M Warner; Ariel Caride; Guilherme C de Oliveira; Micaela Rud; Adrienne Samani; Kyaw Z Hein; Runqing Huang; Diana Jurk; Dong Seong Cho; James J Boslett; Jordan D Miller; Jay L Zweier; João F Passos; Jason D Doles; David J Becherer; Eduardo N Chini
Journal:  Cell Metab       Date:  2018-05-01       Impact factor: 27.287
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