Literature DB >> 27304495

Modulating Cholesterol Homeostasis to Build a Better T Cell.

Yoko Kidani1, Steven J Bensinger2.   

Abstract

There is great interest in discovering targets for in vitro manipulation of autologous T cells that enhance their cytotoxicity against tumor targets as a potent cancer immunotherapy. In a recent Nature paper, Xu and colleagues reveal new insights into the link between cellular cholesterol metabolism and CD8 T cell functions.
Copyright © 2016 Elsevier Inc. All rights reserved.

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Year:  2016        PMID： 27304495     DOI： 10.1016/j.cmet.2016.05.015

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  10 in total

1.  Hydroxycholesterol substitution in ionizable lipid nanoparticles for mRNA delivery to T cells.

Authors:  Savan K Patel; Margaret M Billingsley; Caitlin Frazee; Xuexiang Han; Kelsey L Swingle; Jingya Qin; Mohamad-Gabriel Alameh; Karin Wang; Drew Weissman; Michael J Mitchell
Journal:  J Control Release       Date:  2022-05-23       Impact factor: 11.467

Review 2.  Mevalonate Metabolism in Immuno-Oncology.

Authors:  Georg Gruenbacher; Martin Thurnher
Journal:  Front Immunol       Date:  2017-12-01       Impact factor: 7.561

Review 3.  Transcriptional Regulation of T-Cell Lipid Metabolism: Implications for Plasma Membrane Lipid Rafts and T-Cell Function.

Authors:  George A Robinson; Kirsty E Waddington; Ines Pineda-Torra; Elizabeth C Jury
Journal:  Front Immunol       Date:  2017-11-24       Impact factor: 7.561

Review 4.  Mevalonate metabolism governs cancer immune surveillance.

Authors:  Georg Gruenbacher; Martin Thurnher
Journal:  Oncoimmunology       Date:  2017-07-27       Impact factor: 8.110

5.  Modified LDL Particles Activate Inflammatory Pathways in Monocyte-derived Macrophages: Transcriptome Analysis.

Authors:  Alexander N Orekhov; Yumiko Oishi; Nikita G Nikiforov; Andrey V Zhelankin; Larisa Dubrovsky; Igor A Sobenin; Alexander Kel; Daria Stelmashenko; Vsevolod J Makeev; Kathy Foxx; Xueting Jin; Howard S Kruth; Michael Bukrinsky
Journal:  Curr Pharm Des       Date:  2018       Impact factor: 3.116

6.  Targeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint.

Authors:  Nathalie M Schmidt; Peter A C Wing; Mariana O Diniz; Laura J Pallett; Leo Swadling; James M Harris; Alice R Burton; Anna Jeffery-Smith; Nekisa Zakeri; Oliver E Amin; Stephanie Kucykowicz; Mirjam H Heemskerk; Brian Davidson; Tim Meyer; Joe Grove; Hans J Stauss; Ines Pineda-Torra; Clare Jolly; Elizabeth C Jury; Jane A McKeating; Mala K Maini
Journal:  Nat Commun       Date:  2021-05-14       Impact factor: 17.694

Review 7.  Metabolic Changes in Tumor Microenvironment: How Could They Affect γδ T Cells Functions?

Authors:  Anna Maria Corsale; Marta Di Simone; Elena Lo Presti; Carmela Picone; Francesco Dieli; Serena Meraviglia
Journal:  Cells       Date:  2021-10-26       Impact factor: 6.600

8.  MicroRNA-mediated metabolic reprogramming of chimeric antigen receptor T cells.

Authors:  Seyed Mohammad Ali Hosseini Rad; Joshua Colin Halpin; Supannikar Tawinwung; Koramit Suppipat; Nattiya Hirankarn; Alexander D McLellan
Journal:  Immunol Cell Biol       Date:  2022-05-04       Impact factor: 5.853

Review 9.  The Natural History of T Cell Metabolism.

Authors:  Michel Y Braun
Journal:  Int J Mol Sci       Date:  2021-06-24       Impact factor: 5.923

10.  7-Ketocholesterol Induces Lipid Metabolic Reprogramming and Enhances Cholesterol Ester Accumulation in Cardiac Cells.

Authors:  Mei-Ling Cheng; Hsiang-Yu Tang; Pei-Ting Wu; Cheng-Hung Yang; Chi-Jen Lo; Jui-Fen Lin; Hung-Yao Ho
Journal:  Cells       Date:  2021-12-20       Impact factor: 6.600
  10 in total

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