| Literature DB >> 27304115 |
Michael Spittler1, Kiril Lutsenko1, Constantin Czekelius1.
Abstract
The total synthesis of enantiomerically pure (+)-mesembrine is described. The central pyrrolidine moiety incorporating a quaternary, all-carbon-substituted stereocenter was constructed employing an asymmetric gold-catalyzed cycloisomerization of a 1,4-diynamide.Entities:
Year: 2016 PMID： 27304115 DOI： 10.1021/acs.joc.6b00985
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354