Literature DB >> 27302638

Mediastinal granuloma: a rare cause of dysphagia.

Dejan Micic1, Douglas Kyle Hogarth2, Robert T Kavitt1.   

Abstract

Dysphagia is commonly attributed to disorders arising from dysfunction of the oesophageal mucosa or oesophageal motility. Mediastinal structures causing compression of the oesophagus remain a rare presenting cause of dysphagia. We report a case of a woman presenting with dysphagia to solid foods and associated symptoms of weight loss. Traditional evaluation for dysphagia was unrevealing until cross-sectional imaging suggested a mediastinal obstructive process. The finding of a mediastinal granuloma, distinct from mediastinal fibrosis, as the aetiology of dysphagia is a rare finding, with specific treatment implications. The patient was treated with itraconazole antifungal therapy with an improvement in her symptoms. 2016 BMJ Publishing Group Ltd.

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Year:  2016        PMID: 27302638      PMCID: PMC4932350          DOI: 10.1136/bcr-2016-215536

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  6 in total

1.  Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 15-1991. A 48-year-old man with dysphagia, chest pain, fever, and a subcarinal mass.

Authors: 
Journal:  N Engl J Med       Date:  1991-04-11       Impact factor: 91.245

Review 2.  Histoplasmosis: a clinical and laboratory update.

Authors:  Carol A Kauffman
Journal:  Clin Microbiol Rev       Date:  2007-01       Impact factor: 26.132

Review 3.  Mediastinal fibrosis complicating histoplasmosis.

Authors:  J E Loyd; B F Tillman; J B Atkinson; R M Des Prez
Journal:  Medicine (Baltimore)       Date:  1988-09       Impact factor: 1.889

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Authors:  T J Savides; F G Gress; L J Wheat; S Ikenberry; R H Hawes
Journal:  Gastroenterology       Date:  1995-08       Impact factor: 22.682

5.  Esophageal involvement with mediastinal granuloma.

Authors:  R J Dukes; C V Strimlan; D E Dines; W S Payne; R L MacCarty
Journal:  JAMA       Date:  1976-11-15       Impact factor: 56.272

6.  Case report: fluconazole therapy in histoplasma mediastinal granuloma.

Authors:  M S Maholtz; J H Dauber; S A Yousem
Journal:  Am J Med Sci       Date:  1994-04       Impact factor: 2.378

  6 in total

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