Haiyan Yang1, Zhongjian Chen2, Meijuan Wu3, Tao Lei1, Haifeng Yu1, Minghua Ge4. 1. a Chemotherapy Center, Zhejiang Province Cancer Hospital , Hangzhou , PR China. 2. b Laboratory of Clinical Pharmacy, Zhejiang Province Cancer Hospital , Hangzhou , PR China. 3. c Department of Pathology , Zhejiang Province Cancer Hospital , Hangzhou , PR China. 4. d Department of Head and Neck Surgery , Zhejiang Province Cancer Hospital , Hangzhou , PR China.
Abstract
BACKGROUND: Poorly Differentiated Thyroid Carcinoma (PDTC), especially advanced PDTC, is an aggressive disease and displays a much poorer prognosis compared with well differentiated thyroid carcinoma. Surgery is the recommended treatment in the early stage of PDTC, however, no effective treatment modalities are currently available for advanced PDTC Methods: Two advanced PDTC patients with no radioiodine uptake adopted a cytotoxic chemotherapy with liposomal doxorubicin (35 mg/m(2), day 1) plus cisplatin (75 mg/m(2), day1-3) every 3 weeks. Computer tomography (CT) was performed after 6 cycles (case 1) or 5 cycles (case 2) of chemotherapy RESULTS: Our patients achieved remarkable response with one a Complete Remission (CR) and the other a very good Partial Remission (PR) Conclusion: Our findings indicate that liposomal doxorubicin-based chemotherapy regimens might produce response in PDTC patients, and improve their overall survival and quality of life. Hence we believe this result is very important for oncologists in treating PDTC.
BACKGROUND: Poorly Differentiated Thyroid Carcinoma (PDTC), especially advanced PDTC, is an aggressive disease and displays a much poorer prognosis compared with well differentiated thyroid carcinoma. Surgery is the recommended treatment in the early stage of PDTC, however, no effective treatment modalities are currently available for advanced PDTC Methods: Two advanced PDTC patients with no radioiodine uptake adopted a cytotoxic chemotherapy with liposomal doxorubicin (35 mg/m(2), day 1) plus cisplatin (75 mg/m(2), day1-3) every 3 weeks. Computer tomography (CT) was performed after 6 cycles (case 1) or 5 cycles (case 2) of chemotherapy RESULTS: Our patients achieved remarkable response with one a Complete Remission (CR) and the other a very good Partial Remission (PR) Conclusion: Our findings indicate that liposomal doxorubicin-based chemotherapy regimens might produce response in PDTC patients, and improve their overall survival and quality of life. Hence we believe this result is very important for oncologists in treating PDTC.
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