| Literature DB >> 27300430 |
Ingunn M Stromnes1, Philip D Greenberg2.
Abstract
Metastasis and therapy resistance are cardinal features of pancreatic ductal adenocarcinoma, a commonly lethal malignancy. In this issue of Cancer Cell, Steele et al. show that CXCR2 expression and neutrophils are required for metastasis. In mice treated with advanced disease, inhibiting both CXCR2 and PD1 cooperatively but not individually prolongs survival.Entities:
Mesh：
Year: 2016 PMID： 27300430 DOI： 10.1016/j.ccell.2016.05.013
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743