Gr(i)p the ER to Stress Out Melanoma.

Because of their elevated steady-state stress level, cancer cells are particularly sensitive to perturbation of mechanisms regulating protein homeostasis. In this issue, Cerezo and colleagues show that pharmacologic modulation of GRP78, master regulator of the unfolded protein response in the endoplasmic reticulum, can be exploited for cancer treatment. Published by Elsevier Inc.