Literature DB >> 2729949

Activity of ICI 195,739, a new oral triazole, compared with that of ketoconazole in the therapy of experimental murine blastomycosis.

R M Tucker1, L H Hanson, E Brummer, D A Stevens.   

Abstract

ICI 195,739, a novel orally active triazole, proved 50 times as potent as ketoconazole, produced a clinical cure, and completely eradicated residual infection in a murine model of pulmonary blastomycosis. No other previously tested azole has shown similar activity. Fungicidal activity against Blastomyces dermatitidis was seen in vitro at concentrations 1/40 of those achieved in serum with protective doses.

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Year:  1989        PMID： 2729949      PMCID： PMC172482          DOI： 10.1128/AAC.33.4.573

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  7 in total

1.  Experience with ketoconazole in three major manifestations of progressive coccidioidomycosis.

Authors:  D A Stevens; R L Stiller; P L Williams; A M Sugar
Journal:  Am J Med       Date:  1983-01-24       Impact factor: 4.965

2.  Treatment of systemic mycoses with ketoconazole: emphasis on toxicity and clinical response in 52 patients. National Institute of Allergy and Infectious Diseases collaborative antifungal study.

Authors:  W E Dismukes; A M Stamm; J R Graybill; P C Craven; D A Stevens; R L Stiller; G A Sarosi; G Medoff; C R Gregg; H A Gallis; B T Fields; R L Marier; T A Kerkering; L G Kaplowitz; G Cloud; C Bowles; S Shadomy
Journal:  Ann Intern Med       Date:  1983-01       Impact factor: 25.391

3.  Mouse model of pulmonary blastomycosis: utility, simplicity, and quantitative parameters.

Authors:  R P Harvey; E S Schmid; C C Carrington; D A Stevens
Journal:  Am Rev Respir Dis       Date:  1978-04

4.  Antimicrobial susceptibility testing of yeasts: a turbidimetric technique independent of inoculum size.

Authors:  J N Galgiani; D A Stevens
Journal:  Antimicrob Agents Chemother       Date:  1976-10       Impact factor: 5.191

5.  Activities of the modified polyene N-D-ornithyl amphotericin methyl ester and the azoles ICI 153066, Bay n 7133, and Bay l 9139 compared with those of amphotericin B and ketoconazole in the therapy of experimental blastomycosis.

Authors:  E Lefler; E Brummer; A M Perlman; D A Stevens
Journal:  Antimicrob Agents Chemother       Date:  1985-03       Impact factor: 5.191

6.  Activity of ICI 195,739--a novel, orally active bistriazole--in rodent models of fungal and protozoal infections.

Authors:  J F Ryley; S McGregor; R G Wilson
Journal:  Ann N Y Acad Sci       Date:  1988       Impact factor: 5.691

7.  Treatment of mycoses with itraconazole.

Authors:  R M Tucker; P L Williams; E G Arathoon; D A Stevens
Journal:  Ann N Y Acad Sci       Date:  1988       Impact factor: 5.691
  7 in total
  7 in total

Review 1.  Murine models of blastomycosis, coccidioidomycosis, and histoplasmosis.

Authors:  K N Sorensen; K V Clemons; D A Stevens
Journal:  Mycopathologia       Date:  1999       Impact factor: 2.574

2.  Therapeutic effect of the triazole Bay R 3783 in mouse models of coccidioidomycosis, blastomycosis, and histoplasmosis.

Authors:  D Pappagianis; B L Zimmer; G Theodoropoulos; M Plempel; R F Hector
Journal:  Antimicrob Agents Chemother       Date:  1990-06       Impact factor: 5.191

3.  SCH 39304 in the treatment of acute or established murine pulmonary blastomycosis.

Authors:  E Brummer; L H Hanson; D A Stevens
Journal:  Antimicrob Agents Chemother       Date:  1991-04       Impact factor: 5.191

Review 4.  Systemically administered antifungal agents. A review of their clinical pharmacology and therapeutic applications.

Authors:  C A Lyman; T J Walsh
Journal:  Drugs       Date:  1992-07       Impact factor: 9.546

5.  Comparative efficacies of amphotericin B lipid complex and amphotericin B deoxycholate suspension against murine blastomycosis.

Authors:  K V Clemons; D A Stevens
Journal:  Antimicrob Agents Chemother       Date:  1991-10       Impact factor: 5.191

6.  Activities of the triazole D0870 in vitro and against murine blastomycosis.

Authors:  K V Clemons; L H Hanson; D A Stevens
Journal:  Antimicrob Agents Chemother       Date:  1993-05       Impact factor: 5.191

7.  Efficacy of D0870 compared with those of itraconazole and amphotericin B in two murine models of invasive aspergillosis.

Authors:  D W Denning; L Hall; M Jackson; S Hollis
Journal:  Antimicrob Agents Chemother       Date:  1995-08       Impact factor: 5.191
  7 in total

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