Literature DB >> 2729935

Antibacterial activities of the antiparasitic drugs nifurtimox and benznidazole.

H Hof1.   

Abstract

Both nifurtimox and benznidazole, which are used for the treatment of Chagas' disease, also display marked antibacterial activities. Characteristically for nitroheterocyclic compounds, they are much more active against anaerobic and microaerophilic bacteria than against aerobic bacteria. Nitroreductase-deficient aerobes are completely resistant, whereas SOS-repair-deficient strains are moderately susceptible. Those strains are rapidly killed.

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Year:  1989        PMID： 2729935      PMCID： PMC171504          DOI： 10.1128/AAC.33.3.404

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  11 in total

1.  Systemic treatment of human trichomoniasis with a derivative of nitro-imidazole, 8823 RP.

Authors:  P DUREL; V ROIRON; A SIBOULET; L J BOREL
Journal:  Br J Vener Dis       Date:  1960-03

2.  The versatility of nitro compounds.

Authors:  J M Hamilton-Miller; W Brumfitt
Journal:  J Antimicrob Chemother       Date:  1976-03       Impact factor: 5.790

3.  [The spectrum of antibacterial activity of metronidazole].

Authors:  M Füzi; Z Csukás
Journal:  Zentralbl Bakteriol Orig       Date:  1970

4.  Identification of the DNA adduct formed by metabolism of 1,8-dinitropyrene in Salmonella typhimurium.

Authors:  P J Andrews; M A Quilliam; B E McCarry; D W Bryant; D R McCalla
Journal:  Carcinogenesis       Date:  1986-01       Impact factor: 4.944

5.  Chagas' myocarditis imported into France.

Authors:  J M Brisseau; J P Cebron; T Petit; M Marjolet; P Cuilliere; J Godin; J Y Grolleau
Journal:  Lancet       Date:  1988-05-07       Impact factor: 79.321

Review 6.  The development of 5-nitroimidazoles for the treatment and prophylaxis of anaerobic bacterial infections.

Authors:  P Goldman
Journal:  J Antimicrob Chemother       Date:  1982-08       Impact factor: 5.790

7.  Comparative in vitro activities of niridazole and metronidazole against anaerobic and microaerophilic bacteria.

Authors:  H Hof; V Sticht-Groh; K M Müller
Journal:  Antimicrob Agents Chemother       Date:  1982-08       Impact factor: 5.191

8.  Mode of action of nitro-heterocyclic compounds on Escherichia coli.

Authors:  H Hof; T Chakraborty; R Royer; J P Buisson
Journal:  Drugs Exp Clin Res       Date:  1987

9.  On nitroaryl reductase activities in several Clostridia.

Authors:  L Angermaier; H Simon
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1983-12

10.  Effect of different nitroheterocyclic compounds on aerobic, microaerophilic, and anaerobic bacteria.

Authors:  H Hof; J Ströder; J P Buisson; R Royer
Journal:  Antimicrob Agents Chemother       Date:  1986-11       Impact factor: 5.191
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  3 in total

Review 1.  Nitroimidazoles for the treatment of TB: past, present and future.

Authors:  Tathagata Mukherjee; Helena Boshoff
Journal:  Future Med Chem       Date:  2011-09       Impact factor: 3.808

2.  The fecal, oral, and skin microbiota of children with Chagas disease treated with benznidazole.

Authors:  Carlos Robello; Doris Patricia Maldonado; Anna Hevia; Marina Hoashi; Paola Frattaroli; Valentina Montacutti; Adriana Heguy; Igor Dolgalev; Maricruz Mojica; Gregorio Iraola; Maria G Dominguez-Bello
Journal:  PLoS One       Date:  2019-02-26       Impact factor: 3.240

3.  Biochemical and structural characterization of Haemophilus influenzae nitroreductase in metabolizing nitroimidazoles.

Authors:  Dake Liu; Thisuri N Wanniarachchi; Guangde Jiang; Gustavo Seabra; Shugeng Cao; Steven D Bruner; Yousong Ding
Journal:  RSC Chem Biol       Date:  2022-02-16
  3 in total

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