Vasanthan Tanigasalam1, Ballambattu Vishnu Bhat2, Bethou Adhisivam1, Magadi Gopalakrishna Sridhar3, Kottyen Thazath Harichandrakumar4. 1. Department of Neonatology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, 605 006, India. 2. Department of Neonatology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, 605 006, India. drvishnubhat@yahoo.com. 3. Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India. 4. Department of Biostatistics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India.
Abstract
OBJECTIVE: To evaluate the utility of urinary Neutrophil Gelatinase Associated Lipocalin (NGAL) as a biomarker for predicting Acute Kidney Injury (AKI) and its severity among neonates with perinatal asphyxia. METHODS: This descriptive study included 120 term neonates with perinatal asphyxia. Renal parameters of neonates were monitored and AKI was ascertained as per Acute Kidney Injury Network criteria. Urinary NGAL was estimated and correlated with severity of AKI. RESULTS: Among the 120 neonates with perinatal asphyxia, 55(46 %) had AKI. The median urinary NGAL level was 165 ng/ml (88.8-245.8) in neonates with AKI compared to 58.97(42.8-74.7) in those without AKI. The median NGAL was 134.45(112.2-162.5), 301.2(255.5-361.2), 416.2(412.2-465.5) in AKI stages 1, 2 and 3 respectively. An NGAL cut off value of 86.82 ng/ml had 87 % sensitivity and 87.7 % specificity in predicting AKI. CONCLUSIONS: Urinary NGAL is a useful biomarker for predicting AKI and its severity among neonates with perinatal asphyxia.
OBJECTIVE: To evaluate the utility of urinary Neutrophil Gelatinase Associated Lipocalin (NGAL) as a biomarker for predicting Acute Kidney Injury (AKI) and its severity among neonates with perinatal asphyxia. METHODS: This descriptive study included 120 term neonates with perinatal asphyxia. Renal parameters of neonates were monitored and AKI was ascertained as per Acute Kidney Injury Network criteria. Urinary NGAL was estimated and correlated with severity of AKI. RESULTS: Among the 120 neonates with perinatal asphyxia, 55(46 %) had AKI. The median urinary NGAL level was 165 ng/ml (88.8-245.8) in neonates with AKI compared to 58.97(42.8-74.7) in those without AKI. The median NGAL was 134.45(112.2-162.5), 301.2(255.5-361.2), 416.2(412.2-465.5) in AKI stages 1, 2 and 3 respectively. An NGAL cut off value of 86.82 ng/ml had 87 % sensitivity and 87.7 % specificity in predicting AKI. CONCLUSIONS: Urinary NGAL is a useful biomarker for predicting AKI and its severity among neonates with perinatal asphyxia.
Authors: Gary D V Hankins; Sophia Koen; Alfredo F Gei; Suzanne M Lopez; James W Van Hook; Garland D Anderson Journal: Obstet Gynecol Date: 2002-05 Impact factor: 7.661
Authors: Ravindra L Mehta; John A Kellum; Sudhir V Shah; Bruce A Molitoris; Claudio Ronco; David G Warnock; Adeera Levin Journal: Crit Care Date: 2007 Impact factor: 9.097
Authors: David J Askenazi; Brian A Halloran; Patrick J Heagerty; Robert H Schmicker; Patrick Brophy; Sandra E Juul; Sangeeta Hingorani; Stuart L Goldstein Journal: Pediatr Res Date: 2021-11-30 Impact factor: 3.953
Authors: Özgün Uygur; Özge Altun Köroğlu; Reşit Ertürk Levent; Eser Sözmen; Firat Ergin; Yüksel Atay; Mehmet Yalaz; Mete Akisü; Nilgün Kültürsay Journal: Turk J Med Sci Date: 2021-02-26 Impact factor: 0.973