Literature DB >> 27298520

Yes, It is Possible.

Gautam N Allahbadia1.   

Abstract

Human immunodeficiency virus-serodiscordant couples are actively seeking reproductive assistance and often consider or practice unsafe measures to achieve pregnancy. Reproductive issues and concerns unique to these couples need to be addressed before treatment. Assisted reproduction techniques can minimize the risk of infection and complete families associated with serodiscordant couples. Since 1987, more than 4000 published attempts have been reported in which processed spermatozoa from HIV-seropositive men were used to establish pregnancy in HIV-seronegative women. When the female partner is HIV positive, intrauterine insemination (IUI) will suffice in order to prevent horizontal infection. However, when the male partner is HIV positive, a technique developed in Milan over 15 years ago, involving sperm washing, is used in order to minimize infection of the healthy partner. Some couples need further treatment, due to inherent infertility, with advanced reproductive technology (ART) procedures, such as IVF or ICSI. Recent innovative approaches such as pre-exposure prophylaxis (PrEP) with antiretroviral drugs may reduce further the susceptibility of the uninfected female partner. Numerous ART centers worldwide treat these couples. Most centers are equipped with separate laboratory space for collecting specimens from infected patients and provide separate storage tanks for freezing infected gametes and embryos in order to protect other patients using the facility. There are no reports of HIV infection of laboratory personnel resulting from processing the gametes/embryos for serodiscordant couples using current laboratory protocols. Cross-contamination of the gametes or embryos of other couples in the same laboratory has also not been reported. The risk is theoretical only, particularly when standard universal precautions are used.

Entities:  

Keywords:  HIV; Hepatitis C Virus; Human immunodeficiency virus-serodiscordant couples; Transmission of virus

Year:  2015        PMID: 27298520      PMCID: PMC4870669          DOI: 10.1007/s13224-015-0802-x

Source DB:  PubMed          Journal:  J Obstet Gynaecol India        ISSN: 0975-6434


  20 in total

1.  Preventing vertical transmission of HIV infection.

Authors:  C Peckham; M L Newell
Journal:  N Engl J Med       Date:  2000-10-05       Impact factor: 91.245

2.  Management of HIV serodiscordant couples. The clinician point of view.

Authors:  O Coll; R Vidal; B Martinez de Tejada; J L Ballescá; M Azulay; J A Vanrell
Journal:  Contracept Fertil Sex       Date:  1999-06

3.  Sperm washing and virus nucleic acid detection to reduce HIV and hepatitis C virus transmission in serodiscordant couples wishing to have children.

Authors:  C Pasquier; M Daudin; L Righi; L Berges; L Thauvin; A Berrebi; P Massip; J Puel; L Bujan; J Izopet
Journal:  AIDS       Date:  2000-09-29       Impact factor: 4.177

4.  Safety of sperm washing and ART outcome in 741 HIV-1-serodiscordant couples.

Authors:  V Savasi; E Ferrazzi; C Lanzani; M Oneta; B Parrilla; T Persico
Journal:  Hum Reprod       Date:  2006-11-15       Impact factor: 6.918

5.  Achievements in public health. Reduction in perinatal transmission of HIV infection--United States, 1985-2005.

Authors: 
Journal:  MMWR Morb Mortal Wkly Rep       Date:  2006-06-02       Impact factor: 17.586

Review 6.  Sperm washing techniques address the fertility needs of HIV-seropositive men: a clinical review.

Authors:  Mark V Sauer
Journal:  Reprod Biomed Online       Date:  2005-01       Impact factor: 3.828

Review 7.  Antiretrovirals and safer conception for HIV-serodiscordant couples.

Authors:  Lynn T Matthews; Jennifer A Smit; Susan Cu-Uvin; Deborah Cohan
Journal:  Curr Opin HIV AIDS       Date:  2012-11       Impact factor: 4.283

8.  Insemination with isolated and virologically tested spermatozoa is a safe way for human immunodeficiency type 1 virus-serodiscordant couples with an infected male partner to have a child.

Authors:  Louis Bujan; Christophe Pasquier; Evelyne Labeyrie; Patrick Lanusse-Crousse; Mireille Morucci; Myriam Daudin
Journal:  Fertil Steril       Date:  2004-10       Impact factor: 7.329

9.  Assisted reproduction techniques for HIV serodiscordant couples: 18 months of experience.

Authors:  Jeanine Ohl; Marialuisa Partisani; Christiane Wittemer; Marie-Paule Schmitt; Claudine Cranz; Françoise Stoll-Keller; Catherine Rongieres; Karima Bettahar-Lebugle; Jean-Marie Lang; Israël Nisand
Journal:  Hum Reprod       Date:  2003-06       Impact factor: 6.918

10.  Providing fertility care to men seropositive for human immunodeficiency virus: reviewing 10 years of experience and 420 consecutive cycles of in vitro fertilization and intracytoplasmic sperm injection.

Authors:  Mark V Sauer; Jeff G Wang; Nataki C Douglas; Gary S Nakhuda; Pratibashri Vardhana; Vuk Jovanovic; Michael M Guarnaccia
Journal:  Fertil Steril       Date:  2008-06-13       Impact factor: 7.329

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