| Literature DB >> 27297970 |
J Bourcier1, T Gastinne1, C Leux2, A Moreau3, C Bossard3, B Mahé1, N Blin1, V Dubruille1, C Touzeau1, M Voldoire1, T Guillaume1, P Peterlin1, P Gallas1, A Garnier1, H Maisonneuve4, P Moreau1, N Juge-Morineau6, H Jardel7, P Chevallier1, P Moreau1, S Le Gouill8,9,10.
Abstract
We retrospectively evaluated the role of rituximab (R) in maintenance treatment after autologous stem cell transplantation performed in patients with relapsed follicular lymphoma. We compared the outcome of 67 follicular lymphoma (FL) patients according to the use of rituximab maintenance (RM) or not. All patients received rituximab plus chemotherapy before autologous stem-cell transplantation (ASCT). Patients received median of two lines of prior therapy. The RM schedule was one injection of rituximab every 3 months for 2 years. Median follow-up is 4.6 years. The 3-year progression-free survival (PFS) after ASCT was 86 % with RM vs. 46 % without (p = 0.0045). Median is not reached in the RM arm vs. 31 months in non-RM arm. The 3-year OS was 96 % with RM vs. 78 % without (p = 0.059). The present monocentric study shows that 2 years of RM after ASCT significantly increases response duration for non-naive rituximab relapsed FL patients compared with observation.Entities:
Keywords: Autologous stem cell transplantation; Follicular lymphoma; Relapse; Rituximab maintenance
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Year: 2016 PMID： 27297970 DOI： 10.1007/s00277-016-2705-z
Source DB: PubMed Journal: Ann Hematol ISSN： 0939-5555 Impact factor: 3.673