Literature DB >> 27297784

Clients Place Unique Functional Constraints on Hsp90.

Abbey D Zuehlke1, Len Neckers2.   

Abstract

Heat shock protein 90 kDa (Hsp90) is required for the activation and stabilization of numerous client proteins, but the functional requirements of individual clients remain poorly understood. Utilizing yeast growth assays and mutational analysis, Mishra and colleagues explore the constraints placed on Hsp90 by distinct clients and the relationship between these constraints and overall yeast fitness. Published by Elsevier Ltd.

Entities:  

Keywords:  Hsp90; chaperone-mediated client maturation.; molecular chaperone

Mesh：

Substances：

Year:  2016        PMID： 27297784      PMCID： PMC4930374          DOI： 10.1016/j.tibs.2016.05.011

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  6 in total

1.  ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo.

Authors:  B Panaretou; C Prodromou; S M Roe; R O'Brien; J E Ladbury; P W Piper; L H Pearl
Journal:  EMBO J       Date:  1998-08-17       Impact factor: 11.598

2.  Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone.

Authors:  C Prodromou; S M Roe; R O'Brien; J E Ladbury; P W Piper; L H Pearl
Journal:  Cell       Date:  1997-07-11       Impact factor: 41.582

Review 3.  Hsp90 interaction with clients.

Authors:  G Elif Karagöz; Stefan G D Rüdiger
Journal:  Trends Biochem Sci       Date:  2015-01-09       Impact factor: 13.807

Review 4.  Selective targeting of the stress chaperome as a therapeutic strategy.

Authors:  Tony Taldone; Stefan O Ochiana; Pallav D Patel; Gabriela Chiosis
Journal:  Trends Pharmacol Sci       Date:  2014-09-25       Impact factor: 14.819

Review 5.  Hsp90 and co-chaperones twist the functions of diverse client proteins.

Authors:  Abbey Zuehlke; Jill L Johnson
Journal:  Biopolymers       Date:  2010-03       Impact factor: 2.505

6.  Systematic Mutant Analyses Elucidate General and Client-Specific Aspects of Hsp90 Function.

Authors:  Parul Mishra; Julia M Flynn; Tyler N Starr; Daniel N A Bolon
Journal:  Cell Rep       Date:  2016-04-07       Impact factor: 9.423
  6 in total

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