Kate Smolina1, Barbara Mintzes2, Gillian E Hanley3, Tim F Oberlander4, Steven G Morgan5. 1. School of Population and Public Health, University of British Columbia, Vancouver, BC. kate.smolina@ubc.ca. 2. Faculty of Pharmacy and Charles Perkins Centre, University of Sydney, Australia. 3. Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, BC. 4. Child & Family Research Institute, University of British Columbia, Vancouver, BC. 5. School of Population and Public Health, University of British Columbia, Vancouver, BC.
Abstract
PURPOSE: The aim of this study is to examine the relationship between domperidone (commonly used off-label for lactation stimulation), ventricular arrhythmia and all-cause mortality during the postpartum period. METHODS: This is a retrospective, population-based cohort study of all women with a live birth between 1 January 2002 and 31 December 2011 in British Columbia, Canada. Cox proportional hazards models, yielding hazard ratios (HRs), were used to estimate the risk of hospitalization for ventricular arrhythmia associated with domperidone exposure within six months postpartum. RESULTS: The study population consisted of 225 532 women with 320 351 live births. There was only one death during the six-month postpartum period among the study population, and thus we did not perform any analyses of all-cause mortality. We identified 21 hospitalizations for ventricular arrhythmia. Adjusting for age, smoking and prior history of ventricular arrhythmia and cardiovascular disease, the risk of ventricular arrhythmia hospitalization was approximately double among those exposed to domperidone, but the results were not statistically significant (HR = 2.25, 95%CI 0.84-6.01). Adjustment for body mass index in the 74% of women for whom it was known further reduced the association (HR = 1.69, 95%CI 0.48-5.96). CONCLUSIONS: We found a possible association between exposure to domperidone and hospitalization for ventricular arrhythmia among a cohort of women who have recently given birth. Future studies are needed to confirm this association.
PURPOSE: The aim of this study is to examine the relationship between domperidone (commonly used off-label for lactation stimulation), ventricular arrhythmia and all-cause mortality during the postpartum period. METHODS: This is a retrospective, population-based cohort study of all women with a live birth between 1 January 2002 and 31 December 2011 in British Columbia, Canada. Cox proportional hazards models, yielding hazard ratios (HRs), were used to estimate the risk of hospitalization for ventricular arrhythmia associated with domperidone exposure within six months postpartum. RESULTS: The study population consisted of 225 532 women with 320 351 live births. There was only one death during the six-month postpartum period among the study population, and thus we did not perform any analyses of all-cause mortality. We identified 21 hospitalizations for ventricular arrhythmia. Adjusting for age, smoking and prior history of ventricular arrhythmia and cardiovascular disease, the risk of ventricular arrhythmia hospitalization was approximately double among those exposed to domperidone, but the results were not statistically significant (HR = 2.25, 95%CI 0.84-6.01). Adjustment for body mass index in the 74% of women for whom it was known further reduced the association (HR = 1.69, 95%CI 0.48-5.96). CONCLUSIONS: We found a possible association between exposure to domperidone and hospitalization for ventricular arrhythmia among a cohort of women who have recently given birth. Future studies are needed to confirm this association.
Authors: Carolina Moriello; J Michael Paterson; Pauline Reynier; Matthew Dahl; Wusiman Aibibula; Anat Fisher; John-Michael Gamble; I Fan Kuo; Paul E Ronksley; Brandace Winquist; Kristian B Filion Journal: CMAJ Open Date: 2021-05-14
Authors: Ashleigh Hooimeyer; Alice Bhasale; Lucy Perry; Alice Fabbri; Annim Mohammad; Eliza McEwin; Barbara Mintzes Journal: Pharmacol Res Perspect Date: 2020-12