Maozhi Tang1, Tianyi Li, Hong Liu. 1. Department of Nephrology, Southwest Hospital, Third Military Medical University, Chongqing, China.
Abstract
BACKGROUND: Peritoneal dialysis (PD) and hemodialysis (HD) have been considered the 2 standard pre-transplant dialysis modalities in patients awaiting kidney transplantation. However, the impact of pretransplant dialysis on the short- and long-term post-transplant outcomes remains controversial. METHODS: We searched PubMed, EMBASE and the Cochrane central register of controlled trials for this review. Twelve studies were identified by strict screening for the meta-analysis. RESULTS: We found that pretransplant PD patients had a significantly lower incidence of delayed graft function than HD patients, with an OR 0.67 (95% CI 0.62-0.72, p < 0.05). In contrast, there was no significant difference in the incidence of acute rejection, OR 0.96 (95% CI 0.75-1.16). Pretransplant PD had a better 5-year patient survival rate than HD, with a hazard ratio 0.86 (95% CI 0.79-0.95, p < 0.05); however, there were no significant differences in the graft survival rate (p = 0.08). CONCLUSIONS: We found that PD was a better choice of pretransplant dialysis modality than HD. Video Journal Club 'Cappuccino with Claudio Ronco' at http://www.karger.com/?doi=446272.
BACKGROUND: Peritoneal dialysis (PD) and hemodialysis (HD) have been considered the 2 standard pre-transplant dialysis modalities in patients awaiting kidney transplantation. However, the impact of pretransplant dialysis on the short- and long-term post-transplant outcomes remains controversial. METHODS: We searched PubMed, EMBASE and the Cochrane central register of controlled trials for this review. Twelve studies were identified by strict screening for the meta-analysis. RESULTS: We found that pretransplant PDpatients had a significantly lower incidence of delayed graft function than HDpatients, with an OR 0.67 (95% CI 0.62-0.72, p < 0.05). In contrast, there was no significant difference in the incidence of acute rejection, OR 0.96 (95% CI 0.75-1.16). Pretransplant PD had a better 5-year patient survival rate than HD, with a hazard ratio 0.86 (95% CI 0.79-0.95, p < 0.05); however, there were no significant differences in the graft survival rate (p = 0.08). CONCLUSIONS: We found that PD was a better choice of pretransplant dialysis modality than HD. Video Journal Club 'Cappuccino with Claudio Ronco' at http://www.karger.com/?doi=446272.
Authors: Richard Dumbill; Roderick Jaques; Matthew Robb; Rachel Johnson; Rutger J Ploeg; Maria E Kaisar; Edward J Sharples Journal: J Clin Med Date: 2022-04-15 Impact factor: 4.964
Authors: Ali I Gardezi; Brenda Muth; Adil Ghaffar; Fahad Aziz; Neetika Garg; Maha Mohamed; David Foley; Dixon Kaufman; Arjang Djamali; Didier Mandelbrot; Sandesh Parajuli Journal: Kidney Int Rep Date: 2021-04-17