PURPOSE: To explore and evaluate the potential value of dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) for the prediction of pathologic response to neoadjuvant chemoradiotherapy (nCRT) in oesophageal cancer. MATERIAL AND METHODS: Twenty-six patients underwent DCE-MRI before, during (week 2-3) and after nCRT, but before surgery (pre/per/post, respectively). Histopathologic tumour regression grade (TRG) was assessed after oesophagectomy. Tumour area-under-the-concentration time curve (AUC), time-to-peak (TTP) and slope were calculated. The ability of these DCE-parameters to distinguish good responders (GR, TRG 1-2) from poor responders (noGR, TRG⩾3), and pathologic complete responders (pCR) from no-pCR was assessed. RESULTS: Twelve patients (48%) showed GR of which 8 patients (32%) pCR. Analysis of AUC change throughout treatment, AUCper-pre, was most predictive for GR, at a threshold of 22.7% resulting in a sensitivity of 92%, specificity of 77%, PPV of 79%, and a NPV of 91%. AUCpost-pre was most predictive for pCR, at a threshold of -24.6% resulting in a sensitivity of 83%, specificity of 88%, PPV of 71%, and a NPV of 93%. TTP and slope were not associated with pathologic response. CONCLUSIONS: This study demonstrates that changes in AUC throughout treatment are promising for prediction of histopathologic response to nCRT for oesophageal cancer.
PURPOSE: To explore and evaluate the potential value of dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) for the prediction of pathologic response to neoadjuvant chemoradiotherapy (nCRT) in oesophageal cancer. MATERIAL AND METHODS: Twenty-six patients underwent DCE-MRI before, during (week 2-3) and after nCRT, but before surgery (pre/per/post, respectively). Histopathologic tumour regression grade (TRG) was assessed after oesophagectomy. Tumour area-under-the-concentration time curve (AUC), time-to-peak (TTP) and slope were calculated. The ability of these DCE-parameters to distinguish good responders (GR, TRG 1-2) from poor responders (noGR, TRG⩾3), and pathologic complete responders (pCR) from no-pCR was assessed. RESULTS: Twelve patients (48%) showed GR of which 8 patients (32%) pCR. Analysis of AUC change throughout treatment, AUCper-pre, was most predictive for GR, at a threshold of 22.7% resulting in a sensitivity of 92%, specificity of 77%, PPV of 79%, and a NPV of 91%. AUCpost-pre was most predictive for pCR, at a threshold of -24.6% resulting in a sensitivity of 83%, specificity of 88%, PPV of 71%, and a NPV of 93%. TTP and slope were not associated with pathologic response. CONCLUSIONS: This study demonstrates that changes in AUC throughout treatment are promising for prediction of histopathologic response to nCRT for oesophageal cancer.
Authors: Lucas Goense; Alicia S Borggreve; Sophie E Heethuis; Astrid Lhmw van Lier; Richard van Hillegersberg; Stella Mook; Gert J Meijer; Peter S N van Rossum; Jelle P Ruurda Journal: Br J Radiol Date: 2018-03-14 Impact factor: 3.039
Authors: Puja G Khaitan; Tyler Holliday; Austin Carroll; Wayne L Hofstetter; Erin M Bayley; Nicolas Zhou; Sameer Desale; Thomas J Watson Journal: J Gastrointest Surg Date: 2022-04-12 Impact factor: 3.267
Authors: Lucas Goense; Peter S N van Rossum; Mian Xi; Dipen M Maru; Brett W Carter; Gert J Meijer; Linus Ho; Richard van Hillegersberg; Wayne L Hofstetter; Steven H Lin Journal: Ann Surg Oncol Date: 2018-03-22 Impact factor: 5.344
Authors: A S Borggreve; S Mook; M Verheij; V E M Mul; J J Bergman; A Bartels-Rutten; L C Ter Beek; R G H Beets-Tan; R J Bennink; M I van Berge Henegouwen; L A A Brosens; I L Defize; J M van Dieren; H Dijkstra; R van Hillegersberg; M C Hulshof; H W M van Laarhoven; M G E H Lam; A L H M W van Lier; C T Muijs; W B Nagengast; A J Nederveen; W Noordzij; J T M Plukker; P S N van Rossum; J P Ruurda; J W van Sandick; B L A M Weusten; F E M Voncken; D Yakar; G J Meijer Journal: BMC Cancer Date: 2018-10-20 Impact factor: 4.430