Literature DB >> 27296359

Inhibitory effect of 13 taxane diterpenoids from Chinese yew (Taxus chinensis var. mairei) on the proliferation of HeLa cervical cancer cells.

Hai-Sheng Liu1, Yu-Huan Gao1, Li-Hong Liu1, Wei Liu2, Qing-Wen Shi3, Mei Dong3, Toshikazu Suzuki4, Hiromasa Kiyota5.   

Abstract

The inhibitory effect of 13 taxanes isolated from the Chinese yew (Taxus chinensis var. mairei) on the proliferation of human cervical cancer HeLa cells were examined using an MTT assay. Four compounds having a hydrophobic cinnamate side chain showed antiproliferative activity, which may be due to increased cell permeability.

Entities:  

Keywords:  HeLa cells; Taxus chinensis var. mairei; antiproliferative activity; apoptosis; taxanes

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Year:  2016        PMID： 27296359     DOI： 10.1080/09168451.2016.1194182

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  3 in total

1.  Investigation of bioactivities of Taxus chinensis, Taxus cuspidata, and Taxus × media by gas chromatography-mass spectrometry.

Authors:  Shuqiang Zhang; Xueyan Lu; Tianyao Zheng; Xiaorui Guo; Qi Chen; Zhonghua Tang
Journal:  Open Life Sci       Date:  2021-03-23       Impact factor: 0.938

2.  Yang-Yin-Jie-Du decoction overcomes gefitinib resistance in non-small cell lung cancer via down-regulation of the PI3K/Akt signalling pathway.

Authors:  Shu-Yi Chen; Gao-Chen-Xi Zhang; Qi-Jin Shu
Journal:  Pharm Biol       Date:  2021-12       Impact factor: 3.503

3.  Omic analysis of the endangered Taxaceae species Pseudotaxus chienii revealed the differences in taxol biosynthesis pathway between Pseudotaxus and Taxus yunnanensis trees.

Authors:  Chunna Yu; Chengchao Zhang; Xinyun Xu; Jiefang Huang; Yueyue Chen; Xiujun Luo; Huizhong Wang; Chenjia Shen
Journal:  BMC Plant Biol       Date:  2021-02-19       Impact factor: 4.215
  3 in total

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