| Literature DB >> 27294511 |
Shima Safaiyan1, Nirmal Kannaiyan2, Nicolas Snaidero1,3, Simone Brioschi4, Knut Biber4,5, Simon Yona6, Aimee L Edinger7, Steffen Jung6, Moritz J Rossner1,2, Mikael Simons1,3,8,9.
Abstract
Myelin is synthesized as a multilamellar membrane, but the mechanisms of membrane turnover are unknown. We found that myelin pieces were gradually released from aging myelin sheaths and were subsequently cleared by microglia. Myelin fragmentation increased with age and led to the formation of insoluble, lipofuscin-like lysosomal inclusions in microglia. Thus, age-related myelin fragmentation is substantial, leading to lysosomal storage and contributing to microglial senescence and immune dysfunction in aging.Entities:
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Year: 2016 PMID： 27294511 DOI： 10.1038/nn.4325
Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 24.884