Literature DB >> 27292605

A BAT-Centric Approach to the Treatment of Diabetes: Turn on the Brain.

Mohammed K Hankir1, Michael A Cowley2, Wiebke K Fenske3.   

Abstract

The marked (18)F-flurodeoxyglucose uptake by brown adipose tissue (BAT) enabled its identification in human positron emission tomography imaging studies. In this Perspective, we discuss how glucose extraction by BAT and beige adipose tissue (BeAT) sufficiently impacts on glycemic control. We then present a unique overview of the central circuits modulated by gluco-regulatory hormones, temperature, and glucose itself, which converge on sympathetic preganglionic neurons and whose activation syphon circulating glucose into BAT/BeAT. Targeted stimulation of the sympathetic nervous system at specific nodes to selectively recruit BAT/BeAT may represent a safe and effective means of treating diabetes.
Copyright © 2016 Elsevier Inc. All rights reserved.

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Year:  2016        PMID： 27292605     DOI： 10.1016/j.cmet.2016.05.003

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  16 in total

1.  Overexpressing the hydroxycarboxylic acid receptor 1 in mouse brown adipose tissue restores glucose tolerance and insulin sensitivity in diet-induced obese mice.

Authors:  Hyeon-Young Min; Jiyeon Hwang; Yuna Choi; Young-Hwan Jo
Journal:  Am J Physiol Endocrinol Metab       Date:  2022-07-13       Impact factor: 5.900

2.  Ubiquitin-Specific Protease 2 in the Ventromedial Hypothalamus Modifies Blood Glucose Levels by Controlling Sympathetic Nervous Activation.

Authors:  Mayuko Hashimoto; Masaki Fujimoto; Kohtarou Konno; Ming-Liang Lee; Yui Yamada; Koya Yamashita; Chitoku Toda; Michio Tomura; Masahiko Watanabe; Osamu Inanami; Hiroshi Kitamura
Journal:  J Neurosci       Date:  2022-05-03       Impact factor: 6.709

3.  Myricetin-induced brown adipose tissue activation prevents obesity and insulin resistance in db/db mice.

Authors:  Tao Hu; Xiaoxue Yuan; Gang Wei; Haoshu Luo; Hyuek Jong Lee; Wanzhu Jin
Journal:  Eur J Nutr       Date:  2017-04-24       Impact factor: 5.614

4.  Cold-Activated Brown Adipose Tissue is Associated with Less Cardiometabolic Dysfunction in Young Adults with Obesity.

Authors:  Nicole L Mihalopoulos; Jeffrey T Yap; Britney Beardmore; Richard Holubkov; M Nazeem Nanjee; John M Hoffman
Journal:  Obesity (Silver Spring)       Date:  2020-03-13       Impact factor: 5.002

5.  Hypothalamic dopamine signaling regulates brown fat thermogenesis.

Authors:  Cintia Folgueira; Daniel Beiroa; Begoña Porteiro; Manon Duquenne; Emma Puighermanal; Marcos F Fondevila; Silvia Barja-Fernández; Rosalia Gallego; René Hernández-Bautista; Cecilia Castelao; Ana Senra; Patricia Seoane; Noemi Gómez; Pablo Aguiar; Diana Guallar; Miguel Fidalgo; Amparo Romero-Pico; Roger Adan; Clemence Blouet; Jose Luís Labandeira-García; Françoise Jeanrenaud; Imre Kallo; Zsolt Liposits; Javier Salvador; Vincent Prevot; Carlos Dieguez; Miguel Lopez; Emmanuel Valjent; Gema Frühbeck; Luisa M Seoane; Ruben Nogueiras
Journal:  Nat Metab       Date:  2019-08-19

6.  Diacylglycerol acyltransferase 2 links glucose utilization to fatty acid oxidation in the brown adipocytes.

Authors:  Zehra Irshad; Federica Dimitri; Mark Christian; Victor A Zammit
Journal:  J Lipid Res       Date:  2016-11-11       Impact factor: 5.922

7.  PAT2 regulates vATPase assembly and lysosomal acidification in brown adipocytes.

Authors:  Jiefu Wang; Yasuhiro Onogi; Martin Krueger; Josef Oeckl; Ruth Karlina; Inderjeet Singh; Stefanie M Hauck; Regina Feederle; Yongguo Li; Siegfried Ussar
Journal:  Mol Metab       Date:  2022-05-02       Impact factor: 8.568

8.  The Relationship Between Brown Adipose Tissue Content in Supraclavicular Fat Depots and Insulin Sensitivity in Patients with Type 2 Diabetes Mellitus and Prediabetes.

Authors:  Ekaterina Koksharova; Dmitry Ustyuzhanin; Yury Philippov; Alexander Mayorov; Marina Shestakova; Merab Shariya; Sergey Ternovoy; Ivan Dedov
Journal:  Diabetes Technol Ther       Date:  2017-02       Impact factor: 6.118

9.  Brown adipose tissue (BAT) specific vaspin expression is increased after obesogenic diets and cold exposure and linked to acute changes in DNA-methylation.

Authors:  Juliane Weiner; Kerstin Rohde; Kerstin Krause; Konstanze Zieger; Nora Klöting; Susan Kralisch; Peter Kovacs; Michael Stumvoll; Matthias Blüher; Yvonne Böttcher; John T Heiker
Journal:  Mol Metab       Date:  2017-03-28       Impact factor: 7.422

Review 10.  The dark side of browning.

Authors:  Kirstin A Tamucci; Maria Namwanje; Lihong Fan; Li Qiang
Journal:  Protein Cell       Date:  2017-07-04       Impact factor: 15.328
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