Robert Bies1, Sarah Cook2, Stephen Duffull3. 1. Department of Pharmaceutical Sciences, Center for Data Enabled Science and Engineering State University of New York University at Buffalo, Roswell Park Cancer Institute, Buffalo. 2. Department of Pharmaceutical Sciences, State University of New York University at Buffalo, Buffalo, USA. 3. Otago Pharmacometrics Group, School of Phamacy, University of Otago, Dunedin, New Zealand.