A Sen1, B Erdivanli2, Y Tomak3, A Pergel4. 1. Recep Tayyip Erdogan University, Medical Faculty, Department of Anaesthesiology and Reanimation, Rize, Turkey. 2. Recep Tayyip Erdogan University, Medical Faculty, Department of Anaesthesiology and Reanimation, Rize, Turkey. Electronic address: berdivanli@gmail.com. 3. Sakarya University, Medical Faculty, Anaesthesiology and Reanimation, Sakarya, Turkey. 4. Recep Tayyip Erdogan University, Medical Faculty, Department of General Surgery, Rize, Turkey.
Abstract
STUDY OBJECTIVE: To compare sugammadex with conventional reversal of neuromuscular block in terms of postoperative gastrointestinal motility. DESIGN: Double blinded, randomized, controlled clinical trial. SETTING: Operating room, postoperative recovery area. PATIENTS: Seventy-two patients with ASA physical status I or II, scheduled for total thyroid surgery were studied. INTERVENTIONS: When 4 twitches were observed on train-of-four stimulation, neuromuscular block was reversed conversatively in the control group, and with sugammadex in the study group. MEASUREMENTS: Time to first flatus and feces, incidence of postoperative nausea, vomiting, diarrhea and constipation were collected. MAIN RESULTS:Median time of first flatus was 24 hours (18-32 [10-36]) in the neostigmine group, and 24 (18-28 [12-48]) in the sugammadex group (P > .05). Median (IQR) time of first feces was 24 hours (18-36 [10-48]) in neostigmine group, 32 hours (28-36 [12-72]) in sugammadex group (P > .05). There were no occurrences of nausea, vomiting, diarrhea, or constipation. CONCLUSIONS:Sugammadex may be safely used in cases where postoperative ileus is expected.
RCT Entities:
STUDY OBJECTIVE: To compare sugammadex with conventional reversal of neuromuscular block in terms of postoperative gastrointestinal motility. DESIGN: Double blinded, randomized, controlled clinical trial. SETTING: Operating room, postoperative recovery area. PATIENTS: Seventy-two patients with ASA physical status I or II, scheduled for total thyroid surgery were studied. INTERVENTIONS: When 4 twitches were observed on train-of-four stimulation, neuromuscular block was reversed conversatively in the control group, and with sugammadex in the study group. MEASUREMENTS: Time to first flatus and feces, incidence of postoperative nausea, vomiting, diarrhea and constipation were collected. MAIN RESULTS: Median time of first flatus was 24 hours (18-32 [10-36]) in the neostigmine group, and 24 (18-28 [12-48]) in the sugammadex group (P > .05). Median (IQR) time of first feces was 24 hours (18-36 [10-48]) in neostigmine group, 32 hours (28-36 [12-72]) in sugammadex group (P > .05). There were no occurrences of nausea, vomiting, diarrhea, or constipation. CONCLUSIONS:Sugammadex may be safely used in cases where postoperative ileus is expected.
Authors: L Traeger; T D Hall; S Bedrikovetski; H M Kroon; N N Dudi-Venkata; J W Moore; T Sammour Journal: Tech Coloproctol Date: 2022-09-05 Impact factor: 3.699
Authors: Atousa Deljou; Darrell R Schroeder; Beth A Ballinger; Juraj Sprung; Toby N Weingarten Journal: Mayo Clin Proc Innov Qual Outcomes Date: 2019-08-23