Literature DB >> 27289425

Antigenic landscape of the HIV-1 envelope and new immunological concepts defined by HIV-1 broadly neutralizing antibodies.

Xueling Wu1, Xiang-Peng Kong2.   

Abstract

The isolation of HIV-1 broadly neutralizing antibodies (bnAbs) has demonstrated the ability of the human immune system to mount effective antibody responses against the virus. To harness this immune potential to elicit similar antibody responses by vaccination, it is important to understand the immunological processes that produce them. Here we review recent advances in crystal structural determinations of HIV-1 bnAb epitopes that directly portray the antigenic landscape of the HIV-1 envelope glycoprotein. We also summarize new immunological concepts implicated in bnAb sequences and their lineage studies.
Copyright © 2016 Elsevier Ltd. All rights reserved.

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Year:  2016        PMID： 27289425      PMCID： PMC5086270          DOI： 10.1016/j.coi.2016.05.013

Source DB:  PubMed          Journal:  Curr Opin Immunol        ISSN： 0952-7915            Impact factor:   7.486


  94 in total

Review 1.  Human antibodies that neutralize HIV-1: identification, structures, and B cell ontogenies.

Authors:  Peter D Kwong; John R Mascola
Journal:  Immunity       Date:  2012-09-21       Impact factor: 31.745

2.  Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody.

Authors:  Rui Kong; Kai Xu; Tongqing Zhou; Priyamvada Acharya; Thomas Lemmin; Kevin Liu; Gabriel Ozorowski; Cinque Soto; Justin D Taft; Robert T Bailer; Evan M Cale; Lei Chen; Chang W Choi; Gwo-Yu Chuang; Nicole A Doria-Rose; Aliaksandr Druz; Ivelin S Georgiev; Jason Gorman; Jinghe Huang; M Gordon Joyce; Mark K Louder; Xiaochu Ma; Krisha McKee; Sijy O'Dell; Marie Pancera; Yongping Yang; Scott C Blanchard; Walther Mothes; Dennis R Burton; Wayne C Koff; Mark Connors; Andrew B Ward; Peter D Kwong; John R Mascola
Journal:  Science       Date:  2016-05-13       Impact factor: 47.728

3.  Structural basis of immune evasion at the site of CD4 attachment on HIV-1 gp120.

Authors:  Lei Chen; Young Do Kwon; Tongqing Zhou; Xueling Wu; Sijy O'Dell; Lisa Cavacini; Ann J Hessell; Marie Pancera; Min Tang; Ling Xu; Zhi-Yong Yang; Mei-Yun Zhang; James Arthos; Dennis R Burton; Dimiter S Dimitrov; Gary J Nabel; Marshall R Posner; Joseph Sodroski; Richard Wyatt; John R Mascola; Peter D Kwong
Journal:  Science       Date:  2009-11-20       Impact factor: 47.728

4.  Vaccine induction of antibodies against a structurally heterogeneous site of immune pressure within HIV-1 envelope protein variable regions 1 and 2.

Authors:  Hua-Xin Liao; Mattia Bonsignori; S Munir Alam; Jason S McLellan; Georgia D Tomaras; M Anthony Moody; Daniel M Kozink; Kwan-Ki Hwang; Xi Chen; Chun-Yen Tsao; Pinghuang Liu; Xiaozhi Lu; Robert J Parks; David C Montefiori; Guido Ferrari; Justin Pollara; Mangala Rao; Kristina K Peachman; Sampa Santra; Norman L Letvin; Nicos Karasavvas; Zhi-Yong Yang; Kaifan Dai; Marie Pancera; Jason Gorman; Kevin Wiehe; Nathan I Nicely; Supachai Rerks-Ngarm; Sorachai Nitayaphan; Jaranit Kaewkungwal; Punnee Pitisuttithum; James Tartaglia; Faruk Sinangil; Jerome H Kim; Nelson L Michael; Thomas B Kepler; Peter D Kwong; John R Mascola; Gary J Nabel; Abraham Pinter; Susan Zolla-Pazner; Barton F Haynes
Journal:  Immunity       Date:  2013-01-11       Impact factor: 31.745

5.  Structural basis for diverse N-glycan recognition by HIV-1-neutralizing V1-V2-directed antibody PG16.

Authors:  Marie Pancera; Syed Shahzad-Ul-Hussan; Nicole A Doria-Rose; Jason S McLellan; Robert T Bailer; Kaifan Dai; Sandra Loesgen; Mark K Louder; Ryan P Staupe; Yongping Yang; Baoshan Zhang; Robert Parks; Joshua Eudailey; Krissey E Lloyd; Julie Blinn; S Munir Alam; Barton F Haynes; Mohammed N Amin; Lai-Xi Wang; Dennis R Burton; Wayne C Koff; Gary J Nabel; John R Mascola; Carole A Bewley; Peter D Kwong
Journal:  Nat Struct Mol Biol       Date:  2013-05-26       Impact factor: 15.369

Review 6.  A Blueprint for HIV Vaccine Discovery.

Authors:  Dennis R Burton; Rafi Ahmed; Dan H Barouch; Salvatore T Butera; Shane Crotty; Adam Godzik; Daniel E Kaufmann; M Juliana McElrath; Michel C Nussenzweig; Bali Pulendran; Chris N Scanlan; William R Schief; Guido Silvestri; Hendrik Streeck; Bruce D Walker; Laura M Walker; Andrew B Ward; Ian A Wilson; Richard Wyatt
Journal:  Cell Host Microbe       Date:  2012-10-18       Impact factor: 21.023

7.  Development of Broadly Neutralizing Antibodies and Their Mapping by Monomeric gp120 in Human Immunodeficiency Virus Type 1-Infected Humans and Simian-Human Immunodeficiency Virus SHIVSF162P3N-Infected Macaques.

Authors:  Manxue Jia; Hong Lu; Martin Markowitz; Cecilia Cheng-Mayer; Xueling Wu
Journal:  J Virol       Date:  2016-03-28       Impact factor: 5.103

8.  Germline-like predecessors of broadly neutralizing antibodies lack measurable binding to HIV-1 envelope glycoproteins: implications for evasion of immune responses and design of vaccine immunogens.

Authors:  Xiaodong Xiao; Weizao Chen; Yang Feng; Zhongyu Zhu; Ponraj Prabakaran; Yanping Wang; Mei-Yun Zhang; Nancy S Longo; Dimiter S Dimitrov
Journal:  Biochem Biophys Res Commun       Date:  2009-09-11       Impact factor: 3.575

9.  A next-generation cleaved, soluble HIV-1 Env trimer, BG505 SOSIP.664 gp140, expresses multiple epitopes for broadly neutralizing but not non-neutralizing antibodies.

Authors:  Rogier W Sanders; Ronald Derking; Albert Cupo; Jean-Philippe Julien; Anila Yasmeen; Natalia de Val; Helen J Kim; Claudia Blattner; Alba Torrents de la Peña; Jacob Korzun; Michael Golabek; Kevin de Los Reyes; Thomas J Ketas; Marit J van Gils; C Richter King; Ian A Wilson; Andrew B Ward; P J Klasse; John P Moore
Journal:  PLoS Pathog       Date:  2013-09-19       Impact factor: 6.823

10.  Viral variants that initiate and drive maturation of V1V2-directed HIV-1 broadly neutralizing antibodies.

Authors:  Jinal N Bhiman; Colin Anthony; Nicole A Doria-Rose; Owen Karimanzira; Chaim A Schramm; Thandeka Khoza; Dale Kitchin; Gordon Botha; Jason Gorman; Nigel J Garrett; Salim S Abdool Karim; Lawrence Shapiro; Carolyn Williamson; Peter D Kwong; John R Mascola; Lynn Morris; Penny L Moore
Journal:  Nat Med       Date:  2015-10-12       Impact factor: 53.440
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  12 in total

1.  Clade C HIV-1 Envelope Vaccination Regimens Differ in Their Ability To Elicit Antibodies with Moderate Neutralization Breadth against Genetically Diverse Tier 2 HIV-1 Envelope Variants.

Authors:  Samantha Burton; Lori M Spicer; Tysheena P Charles; Sailaja Gangadhara; Pradeep B J Reddy; Tiffany M Styles; Vijayakumar Velu; Sudhir Pai Kasturi; Traci Legere; Eric Hunter; Bali Pulendran; Rama Amara; Peter Hraber; Cynthia A Derdeyn
Journal:  J Virol       Date:  2019-03-21       Impact factor: 5.103

2.  Comprehensive Mapping of HIV-1 Escape from a Broadly Neutralizing Antibody.

Authors:  Adam S Dingens; Hugh K Haddox; Julie Overbaugh; Jesse D Bloom
Journal:  Cell Host Microbe       Date:  2017-06-01       Impact factor: 21.023

3.  Susceptibility to Neutralization by Broadly Neutralizing Antibodies Generally Correlates with Infected Cell Binding for a Panel of Clade B HIV Reactivated from Latent Reservoirs.

Authors:  Yanqin Ren; Maria Korom; Rebecca M Lynch; R Brad Jones; Ronald Truong; Dora Chan; Szu-Han Huang; Colin C Kovacs; Erika Benko; Jeffrey T Safrit; John Lee; Hermes Garbán; Richard Apps; Harris Goldstein
Journal:  J Virol       Date:  2018-11-12       Impact factor: 5.103

4.  Conserved HIV Epitopes for an Effective HIV Vaccine.

Authors:  Bikash Sahay; Cuong Q Nguyen; Janet K Yamamoto
Journal:  J Clin Cell Immunol       Date:  2017-08-30

5.  Complete functional mapping of infection- and vaccine-elicited antibodies against the fusion peptide of HIV.

Authors:  Adam S Dingens; Priyamvada Acharya; Hugh K Haddox; Reda Rawi; Kai Xu; Gwo-Yu Chuang; Hui Wei; Baoshan Zhang; John R Mascola; Bridget Carragher; Clinton S Potter; Julie Overbaugh; Peter D Kwong; Jesse D Bloom
Journal:  PLoS Pathog       Date:  2018-07-05       Impact factor: 6.823

6.  Identification of HIV gp41-specific antibodies that mediate killing of infected cells.

Authors:  Katherine L Williams; Megan Stumpf; Nicole Elise Naiman; Shilei Ding; Meghan Garrett; Theodore Gobillot; Dani Vézina; Katharine Dusenbury; Nitya S Ramadoss; Ryan Basom; Peter S Kim; Andrés Finzi; Julie Overbaugh
Journal:  PLoS Pathog       Date:  2019-02-19       Impact factor: 6.823

Review 7.  GII.4 Human Norovirus: Surveying the Antigenic Landscape.

Authors:  Michael L Mallory; Lisa C Lindesmith; Rachel L Graham; Ralph S Baric
Journal:  Viruses       Date:  2019-02-20       Impact factor: 5.048

8.  Characteristics of Envelope Genes in a Chinese Chronically HIV-1 Infected Patient With Broadly Neutralizing Activity.

Authors:  Dai Zhang; Sen Zou; Yuanyuan Hu; Jiali Hou; Xintao Hu; Li Ren; Liying Ma; Xiang He; Yiming Shao; Kunxue Hong
Journal:  Front Microbiol       Date:  2019-05-24       Impact factor: 5.640

9.  5' Rapid Amplification of cDNA Ends and Illumina MiSeq Reveals B Cell Receptor Features in Healthy Adults, Adults With Chronic HIV-1 Infection, Cord Blood, and Humanized Mice.

Authors:  Eric Waltari; Manxue Jia; Caroline S Jiang; Hong Lu; Jing Huang; Cristina Fernandez; Andrés Finzi; Daniel E Kaufmann; Martin Markowitz; Moriya Tsuji; Xueling Wu
Journal:  Front Immunol       Date:  2018-03-26       Impact factor: 7.561

10.  Structural Definition of a Unique Neutralization Epitope on the Receptor-Binding Domain of MERS-CoV Spike Glycoprotein.

Authors:  Senyan Zhang; Panpan Zhou; Pengfei Wang; Yangyang Li; Liwei Jiang; Wenxu Jia; Han Wang; Angela Fan; Dongli Wang; Xuanling Shi; Xianyang Fang; Michal Hammel; Shuying Wang; Xinquan Wang; Linqi Zhang
Journal:  Cell Rep       Date:  2018-07-10       Impact factor: 9.423
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