| Literature DB >> 27289046 |
A V Vasilevskaya1, A V Yantsevich1, G V Sergeev1, A P Lemish2, S A Usanov1, A A Gilep3.
Abstract
Problems arising during treatment of tuberculosis are well known, therefore studies of Mycobacterium drug molecular targets are an area of particular importance. Members of the cytochrome P450 family (CYP) may belong to potential candidates for drug targets being involved in metabolism of biologically important molecules in the host organism. CYP124 of Mycobacterium tuberculosis (MTCYP124) catalyzes ω-hydroxylation of methyl-branched lipids. The data obtained in the present study indicate that this enzyme can also oxidize provitamin D3 (7-dehydrocholesterol) and vitamin D3. We found that the final product is different from 1α- and 25-hydroxyvitamin D3, so we propose that MTCYP124 is involved in alternative pathway for metabolism of vitamin D3.Entities:
Keywords: 7-Dehydrocholesterol; Cytochrome P450; Steroid metabolism; Vitamin D
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Year: 2016 PMID： 27289046 DOI： 10.1016/j.jsbmb.2016.05.021
Source DB: PubMed Journal: J Steroid Biochem Mol Biol ISSN： 0960-0760 Impact factor: 4.292