Amoha Bajaj1, Neha A John-Henderson2, Jenny M Cundiff2, Anna L Marsland2, Stephen B Manuck2, Thomas W Kamarck3. 1. Department of Psychology, University of Pittsburgh, PA, USA. Electronic address: amb311@pitt.edu. 2. Department of Psychology, University of Pittsburgh, PA, USA. 3. Department of Psychology, University of Pittsburgh, PA, USA; Department of Psychiatry, University of Pittsburgh, PA, USA.
Abstract
OBJECTIVE: Systemic inflammation is thought to be a biological mediator between social relationship quality and premature mortality. Empirical work has yielded mixed support for an association of social relationship variables with systemic inflammation, perhaps due to methodological limitations. To date, research in this literature has focused on global perceptions of social relationships, with limited attention to the covariance of characteristics of daily social interactions with inflammation. Here, we examine whether daily interactions, as assessed by ecological momentary assessment (EMA), associate with peripheral markers of inflammation among midlife and older adults. METHODS: Global social support and integration were measured using the Interpersonal Support Evaluation List (ISEL) and the Social Network Index (SNI), respectively, in older adults from the Pittsburgh Healthy Heart Project (PHHP), and in middle-aged adults from the Adult Health and Behavior Project-II (AHAB-II). Using time-sampled EMA, we assessed the proportion of the day spent in positive and negative social interactions. Systemic markers of inflammation were interleukin (IL)-6 and C-reactive protein (CRP). RESULTS: Global measures of support and integration did not associate with inflammation in either sample. In older adults, relative frequency of total positive interactions, those with close others (i.e. spouse, friends, family), and those with coworkers predicted lower concentrations of IL-6 in fully adjusted models, accounting for age, sex, race, education, BMI, smoking and alcohol. In middle-aged adults, relative frequency of positive interactions with close others was also inversely associated with IL-6 level and relative frequency of negative marital interactions was unexpectedly inversely associated with CRP level. CONCLUSIONS: Characteristics of daily social interactions among midlife and older adults associate with markers of systemic inflammation that are known to predict risk for cardiovascular disease. Ambulatory measures may better capture health-relevant social processes in daily life than retrospective, global self-report measures. Published by Elsevier Inc.
OBJECTIVE:Systemic inflammation is thought to be a biological mediator between social relationship quality and premature mortality. Empirical work has yielded mixed support for an association of social relationship variables with systemic inflammation, perhaps due to methodological limitations. To date, research in this literature has focused on global perceptions of social relationships, with limited attention to the covariance of characteristics of daily social interactions with inflammation. Here, we examine whether daily interactions, as assessed by ecological momentary assessment (EMA), associate with peripheral markers of inflammation among midlife and older adults. METHODS: Global social support and integration were measured using the Interpersonal Support Evaluation List (ISEL) and the Social Network Index (SNI), respectively, in older adults from the Pittsburgh Healthy Heart Project (PHHP), and in middle-aged adults from the Adult Health and Behavior Project-II (AHAB-II). Using time-sampled EMA, we assessed the proportion of the day spent in positive and negative social interactions. Systemic markers of inflammation were interleukin (IL)-6 and C-reactive protein (CRP). RESULTS: Global measures of support and integration did not associate with inflammation in either sample. In older adults, relative frequency of total positive interactions, those with close others (i.e. spouse, friends, family), and those with coworkers predicted lower concentrations of IL-6 in fully adjusted models, accounting for age, sex, race, education, BMI, smoking and alcohol. In middle-aged adults, relative frequency of positive interactions with close others was also inversely associated with IL-6 level and relative frequency of negative marital interactions was unexpectedly inversely associated with CRP level. CONCLUSIONS: Characteristics of daily social interactions among midlife and older adults associate with markers of systemic inflammation that are known to predict risk for cardiovascular disease. Ambulatory measures may better capture health-relevant social processes in daily life than retrospective, global self-report measures. Published by Elsevier Inc.
Entities:
Keywords:
Cardiovascular disease; Close others; Ecological momentary assessment; Inflammation; Marital interactions; Social integration; Social interactions; Social support
Authors: Evangelia Delistamati; Maria A Samakouri; Elizabeth Anne Davis; Theofanis Vorvolakos; Kiriakos Xenitidis; Miltos Livaditis Journal: Int J Soc Psychiatry Date: 2006-11
Authors: Meredith S Shiels; Hormuzd A Katki; Neal D Freedman; Mark P Purdue; Nicolas Wentzensen; Britton Trabert; Cari M Kitahara; Michael Furr; Yan Li; Troy J Kemp; James J Goedert; Cindy M Chang; Eric A Engels; Neil E Caporaso; Ligia A Pinto; Allan Hildesheim; Anil K Chaturvedi Journal: J Natl Cancer Inst Date: 2014-10-01 Impact factor: 13.506
Authors: Jennifer E Graham-Engeland; Nancy L Sin; Joshua M Smyth; Dusti R Jones; Erik L Knight; Martin J Sliwinski; David M Almeida; Mindy J Katz; Richard B Lipton; Christopher G Engeland Journal: Brain Behav Immun Date: 2018-09-11 Impact factor: 7.217
Authors: Jacqueline M Torres; Elissa S Epel; Tu My To; Anne Lee; Allison E Aiello; Mary N Haan Journal: Soc Sci Med Date: 2018-05-16 Impact factor: 4.634