BACKGROUND: Although changes to gait are an important clinical feature of progressive supranuclear palsy (PSP), systematic analyses have not been well examined, especially in comparison to Parkinson's disease (PD). METHODS: The characteristics of gait in 20 PSP patients (14 males and 6 females) were evaluated in comparison to 124 PD patients (64 males and 60 females) and 24 controls, that is, healthy age-matched adults (5 males and 19 females). Gait in patients was recorded in a 10-m walking test at a self-selected speed. During this time, patients felt most comfortable while wearing a new portable triaxial accelerometer rhythmogram device. Gait variables among the 3 groups were compared. RESULTS: Both PSP and PD patients shared the following similar hypokinetic gait characteristics: decreased velocity, step length, cadence and mean acceleration. Step time and variability in step time were mutually related. However, among the 3 groups, PSP patients showed characteristically low vertical displacement and a higher acceleration than PD patients at the same cadence. CONCLUSION: Although PSP and PD patients showed similar hypokinetic gait, a reduced vertical displacement characterized walking in PSP patients, differing substantially from the characteristics of walking displayed by PD patients.
BACKGROUND: Although changes to gait are an important clinical feature of progressive supranuclear palsy (PSP), systematic analyses have not been well examined, especially in comparison to Parkinson's disease (PD). METHODS: The characteristics of gait in 20 PSPpatients (14 males and 6 females) were evaluated in comparison to 124 PDpatients (64 males and 60 females) and 24 controls, that is, healthy age-matched adults (5 males and 19 females). Gait in patients was recorded in a 10-m walking test at a self-selected speed. During this time, patients felt most comfortable while wearing a new portable triaxial accelerometer rhythmogram device. Gait variables among the 3 groups were compared. RESULTS: Both PSP and PDpatients shared the following similar hypokinetic gait characteristics: decreased velocity, step length, cadence and mean acceleration. Step time and variability in step time were mutually related. However, among the 3 groups, PSPpatients showed characteristically low vertical displacement and a higher acceleration than PDpatients at the same cadence. CONCLUSION: Although PSP and PDpatients showed similar hypokinetic gait, a reduced vertical displacement characterized walking in PSPpatients, differing substantially from the characteristics of walking displayed by PDpatients.
Authors: Ralph Jasper Mobbs; Jordan Perring; Suresh Mahendra Raj; Monish Maharaj; Nicole Kah Mun Yoong; Luke Wicent Sy; Rannulu Dineth Fonseka; Pragadesh Natarajan; Wen Jie Choy Journal: Mhealth Date: 2022-01-20
Authors: Farwa Ali; Stacy R Loushin; Hugo Botha; Keith A Josephs; Jennifer L Whitwell; Kenton Kaufman Journal: J Neurol Sci Date: 2021-08-25 Impact factor: 4.553