Literature DB >> 27287941

A Case of Unexplained Cerebral Sinus Thrombosis in a 22-Year-Old Obese Caucasian Woman.

Jansen N Seheult1, Irina Chibisov2.   

Abstract

Herein, we present the case of a 22-year old obese Caucasian woman female with no acquired thrombophilic risk factors who was diagnosed with extensive cerebral sinus thrombosis. A detailed thrombophilia workup demonstrated persistently elevated plasminogen activator inhibitor 1 (PAI-1) activity levels, with an elevated PAI-1 antigen concentration and homozygosity for the PAI-1 4G allele (4G/4G genotype). The patient was treated with indefinite warfarin anticoagulation medication due to the unprovoked nature of her thrombotic event. Disturbances in the fibrinolytic system, in particular PAI-1, have been related to an increased risk of arterial and venous thrombosis. In this article, we discuss the pathophysiology of hypofibrinolysis associated with elevated PAI-1 levels and the PAI-1 4G/5G polymorphism. © American Society for Clinical Pathology, 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  cerebral sinus thrombosis; gene promoter regions; hypofibrinolysis; plasminogen activator inhibitor 1; plasminogen inactivators; venous thrombosis

Mesh：

Substances：

Year:  2016        PMID： 27287941      PMCID： PMC4985772          DOI： 10.1093/labmed/lmw023

Source DB:  PubMed          Journal:  Lab Med        ISSN： 0007-5027


  42 in total

1.  Coagulation factor XIIIa is inactivated by plasmin.

Authors:  Woosuk S Hur; Nima Mazinani; X J David Lu; Heidi M Britton; James R Byrnes; Alisa S Wolberg; Christian J Kastrup
Journal:  Blood       Date:  2015-09-10       Impact factor: 22.113

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Authors:  E K Kruithof
Journal:  Enzyme       Date:  1988

3.  PAI-1 produced ex vivo by human adipose tissue is relevant to PAI-1 blood level.

Authors:  P E Morange; M C Alessi; M Verdier; D Casanova; G Magalon; I Juhan-Vague
Journal:  Arterioscler Thromb Vasc Biol       Date:  1999-05       Impact factor: 8.311

4.  Plasminogen activator inhibitor (PAI-1) in plasma and platelets.

Authors:  N A Booth; A J Simpson; A Croll; B Bennett; I R MacGregor
Journal:  Br J Haematol       Date:  1988-11       Impact factor: 6.998

5.  Dexamethasone induction of an inhibitor of plasminogen activator in HTC hepatoma cells.

Authors:  B J Cwikel; P A Barouski-Miller; P L Coleman; T D Gelehrter
Journal:  J Biol Chem       Date:  1984-06-10       Impact factor: 5.157

6.  Plasminogen activator inhibitor-1 mRNA is expressed in platelets and megakaryocytes and the megakaryoblastic cell line CHRF-288.

Authors:  B A Konkle; P K Schick; X He; R J Liu; E M Mazur
Journal:  Arterioscler Thromb       Date:  1993-05

7.  The PAI-1 gene 4G/5G polymorphism and deep vein thrombosis in patients with inherited thrombophilia.

Authors:  Maria Teresa Sartori; Cristina Danesin; Graziella Saggiorato; Daniela Tormene; Paolo Simioni; Luca Spiezia; Giovanni Maurizio Patrassi; Antonio Girolami
Journal:  Clin Appl Thromb Hemost       Date:  2003-10       Impact factor: 2.389

8.  Plasminogen activator inhibitor in plasma: risk factor for recurrent myocardial infarction.

Authors:  A Hamsten; U de Faire; G Walldius; G Dahlén; A Szamosi; C Landou; M Blombäck; B Wiman
Journal:  Lancet       Date:  1987-07-04       Impact factor: 79.321

Review 9.  New insights into the molecular mechanisms of the fibrinolytic system.

Authors:  D C Rijken; H R Lijnen
Journal:  J Thromb Haemost       Date:  2008-11-08       Impact factor: 5.824

10.  Purification and characterization of a plasminogen activator inhibitor 1 binding protein from human plasma. Identification as a multimeric form of S protein (vitronectin).

Authors:  P J Declerck; M De Mol; M C Alessi; S Baudner; E P Pâques; K T Preissner; G Müller-Berghaus; D Collen
Journal:  J Biol Chem       Date:  1988-10-25       Impact factor: 5.157
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