Giovanni Pellegrino1,2,3, Mario Tombini1,2, Giuseppe Curcio4, Chiara Campana1,2, Giovanni Di Pino1,2, Giovanni Assenza1,2, Leo Tomasevic5, Vincenzo Di Lazzaro1,2. 1. 1 Unit of Neurology, Neurophysiology, Neurobiology, Department of Medicine, Università Campus Bio-Medico di Roma, Rome, Italy. 2. 2 Fondazione Alberto Sordi-Research Institute for Ageing, Rome, Italy. 3. 3 Multimodal Functional Imaging Laboratory, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada. 4. 4 Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy. 5. 5 Danish Research Center for Magnetic Resonance (DRCMR), Hvidovre, Denmark.
Abstract
INTRODUCTION: We aimed to test differences between healthy subjects and patients with respect to slow wave activity during wakefulness and sleep. METHODS: Fifteen patients affected by nonlesional focal epilepsy originating within temporal areas and fourteen matched controls underwent a 24-hour EEG recording. We studied the EEG power spectral density during wakefulness and sleep in delta (1-4 Hz), theta (5-7 Hz), alpha (8-11 Hz), sigma (12-15 Hz), and beta (16-20 Hz) bands. RESULTS: During sleep, patients with focal epilepsy showed higher power from delta to beta frequency bands compared with controls. The effect was widespread for alpha band and above, while localized over the affected hemisphere for delta (sleep cycle 1, P = .006; sleep cycle 2, P = .008; sleep cycle 3, P = .017). The analysis of interhemispheric differences showed that the only frequency band stronger over the affected regions was the delta band during the first 2 sleep cycles (sleep cycle 1, P = .014; sleep cycle 2, P = .002). During wakefulness, patients showed higher delta/theta activity over the affected regions compared with controls. CONCLUSIONS: Patients with focal epilepsy showed a pattern of power increases characterized by a selective slow wave activity enhancement over the epileptic regions during daytime and sleep. This phenomenon was stronger and asymmetric during the first sleep cycles.
INTRODUCTION: We aimed to test differences between healthy subjects and patients with respect to slow wave activity during wakefulness and sleep. METHODS: Fifteen patients affected by nonlesional focal epilepsy originating within temporal areas and fourteen matched controls underwent a 24-hour EEG recording. We studied the EEG power spectral density during wakefulness and sleep in delta (1-4 Hz), theta (5-7 Hz), alpha (8-11 Hz), sigma (12-15 Hz), and beta (16-20 Hz) bands. RESULTS: During sleep, patients with focal epilepsy showed higher power from delta to beta frequency bands compared with controls. The effect was widespread for alpha band and above, while localized over the affected hemisphere for delta (sleep cycle 1, P = .006; sleep cycle 2, P = .008; sleep cycle 3, P = .017). The analysis of interhemispheric differences showed that the only frequency band stronger over the affected regions was the delta band during the first 2 sleep cycles (sleep cycle 1, P = .014; sleep cycle 2, P = .002). During wakefulness, patients showed higher delta/theta activity over the affected regions compared with controls. CONCLUSIONS:Patients with focal epilepsy showed a pattern of power increases characterized by a selective slow wave activity enhancement over the epileptic regions during daytime and sleep. This phenomenon was stronger and asymmetric during the first sleep cycles.
Authors: Giovanni Pellegrino; Matteo Maran; Cristina Turco; Luca Weis; Giovanni Di Pino; Francesco Piccione; Giorgio Arcara Journal: Neural Plast Date: 2018-01-11 Impact factor: 3.599
Authors: Giovanni Pellegrino; Leo Tomasevic; Damian Marc Herz; Kit Melissa Larsen; Hartwig Roman Siebner Journal: Front Hum Neurosci Date: 2018-09-21 Impact factor: 3.169
Authors: Giovanni Pellegrino; Giorgio Arcara; Anna Maria Cortese; Luca Weis; Silvia Di Tomasso; Gino Marioni; Stefano Masiero; Francesco Piccione Journal: Neuroimage Clin Date: 2019-11-12 Impact factor: 4.881