Literature DB >> 27287115

A doxorubicin delivery system: Samarium/mesoporous bioactive glass/alginate composite microspheres.

Ying Zhang1, Xiang Wang2, Yanli Su2, Dongya Chen2, Wenxing Zhong2.   

Abstract

Samarium (Sm) incorporated mesoporous bioactive glasses (MBG) microspheres have been prepared using the method of alginate cross-linking with Ca(2+) ions. The in vitro bioactivities of Sm/MBG/alginate microspheres were studied by immersing in simulated body fluid (SBF) for various periods. The results indicated that the Sm/MBG/alginate microspheres have a faster apatite formation rate on the surface. To investigate their delivery properties further, doxorubicin (DOX) was selected as a model drug. The results showed that the Sm/MBG/alginate microspheres exhibit sustained DOX delivery, and their release mechanism is controlled by Fickian diffusion according the Higuchi model. In addition, the delivery of DOX from Sm/MBG/alginate microspheres can be dominated by changing the doping concentration of Sm and the values of pH microenvironment. These all revealed that this material is a promising candidate for the therapy of bone cancer.
Copyright © 2016 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Doxorubicin release; Mesoporous bioactive glasses; Samarium

Mesh：

Substances：

Year:  2016        PMID： 27287115     DOI： 10.1016/j.msec.2016.05.019

Source DB:  PubMed          Journal:  Mater Sci Eng C Mater Biol Appl        ISSN： 0928-4931            Impact factor:   7.328


  6 in total

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Journal:  Int J Pharm       Date:  2019-08-14       Impact factor: 5.875

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Authors:  Guorong Jia; Juno Van Valkenburgh; Austin Z Chen; Quan Chen; Jindian Li; Changjing Zuo; Kai Chen
Journal:  Wiley Interdiscip Rev Nanomed Nanobiotechnol       Date:  2021-08-17

Review 3.  Mesoporous Bioactive Glasses in Cancer Diagnosis and Therapy: Stimuli-Responsive, Toxicity, Immunogenicity, and Clinical Translation.

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Journal:  Adv Sci (Weinh)       Date:  2021-11-19       Impact factor: 16.806

4.  Combination of Goniothalamin and Sol-Gel-Derived Bioactive Glass 45S5 Enhances Growth Inhibitory Activity via Apoptosis Induction and Cell Cycle Arrest in Breast Cancer Cells MCF-7.

Authors:  Siti Aishah Abu Bakar; Abdul Manaf Ali; Siti Noor Fazliah Mohd Noor; Shahrul Bariyah Sahul Hamid; Nur Asna Azhar; Noor Muzamil Mohamad; Nor Hazwani Ahmad
Journal:  Biomed Res Int       Date:  2022-07-14       Impact factor: 3.246

5.  Radiopaque and uniform alginate microspheres loaded with tantalum nanoparticles for real-time imaging during transcatheter arterial embolization.

Authors:  Jian Zeng; Ling Li; Hongsen Zhang; Jianye Li; Lingli Liu; Guofeng Zhou; Qing Du; Chuansheng Zheng; Xiangliang Yang
Journal:  Theranostics       Date:  2018-08-10       Impact factor: 11.556

Review 6.  Bioactive glasses incorporating less-common ions to improve biological and physical properties.

Authors:  Usanee Pantulap; Marcela Arango-Ospina; Aldo R Boccaccini
Journal:  J Mater Sci Mater Med       Date:  2021-12-23       Impact factor: 3.896
  6 in total

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