Literature DB >> 27285058

Structure and function of the Mind bomb E3 ligase in the context of Notch signal transduction.

Bingqian Guo1, Brian J McMillan2, Stephen C Blacklow3.   

Abstract

The Notch signaling pathway has a critical role in cell fate determination and tissue homeostasis in a variety of different lineages. In the context of normal Notch signaling, the Notch receptor of the 'signal-receiving' cell is activated in trans by a Notch ligand from a neighboring 'signal-sending' cell. Genetic studies in several model organisms have established that ubiquitination of the Notch ligand, and its regulated endocytosis, is essential for transmission of this activation signal. In mammals, this ubiquitination step is dependent on the protein Mind bomb 1 (Mib1), a large multi-domain RING-type E3 ligase, and its direct interaction with the intracellular tails of Notch ligand molecules. Here, we discuss our current understanding of Mind bomb structure and mechanism in the context of Notch signaling and beyond.
Copyright © 2016 Elsevier Ltd. All rights reserved.

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Year:  2016        PMID： 27285058      PMCID： PMC5143217          DOI： 10.1016/j.sbi.2016.05.012

Source DB:  PubMed          Journal:  Curr Opin Struct Biol        ISSN： 0959-440X            Impact factor:   6.809


  37 in total

Review 1.  RINGs hold the key to ubiquitin transfer.

Authors:  Rhesa Budhidarmo; Yoshio Nakatani; Catherine L Day
Journal:  Trends Biochem Sci       Date:  2011-12-10       Impact factor: 13.807

Review 2.  Notch ligand endocytosis: mechanistic basis of signaling activity.

Authors:  Abdiwahab A Musse; Laurence Meloty-Kapella; Gerry Weinmaster
Journal:  Semin Cell Dev Biol       Date:  2012-01-24       Impact factor: 7.727

3.  Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth.

Authors:  Joseph Mertz; Haiyan Tan; Vishwajeeth Pagala; Bing Bai; Ping-Chung Chen; Yuxin Li; Ji-Hoon Cho; Timothy Shaw; Xusheng Wang; Junmin Peng
Journal:  Mol Cell Proteomics       Date:  2015-04-30       Impact factor: 5.911

4.  A tail of two sites: a bipartite mechanism for recognition of notch ligands by mind bomb E3 ligases.

Authors:  Brian J McMillan; Björn Schnute; Nadja Ohlenhard; Brandon Zimmerman; Laura Miles; Natalia Beglova; Thomas Klein; Stephen C Blacklow
Journal:  Mol Cell       Date:  2015-03-05       Impact factor: 17.970

5.  Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of delta.

Authors:  E C Lai; G A Deblandre; C Kintner; G M Rubin
Journal:  Dev Cell       Date:  2001-12       Impact factor: 12.270

6.  The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor.

Authors:  Li Zhang; Louise Fairall; Benjamin T Goult; Anna C Calkin; Cynthia Hong; Christopher J Millard; Peter Tontonoz; John W R Schwabe
Journal:  Genes Dev       Date:  2011-06-15       Impact factor: 11.361

7.  The intracellular deletions of Delta and Serrate define dominant negative forms of the Drosophila Notch ligands.

Authors:  X Sun; S Artavanis-Tsakonas
Journal:  Development       Date:  1996-08       Impact factor: 6.868

8.  Structural and functional characterization of the NHR1 domain of the Drosophila neuralized E3 ligase in the notch signaling pathway.

Authors:  Fahu He; Kohei Saito; Naohiro Kobayashi; Takushi Harada; Satoru Watanabe; Takanori Kigawa; Peter Güntert; Osamu Ohara; Akiko Tanaka; Satoru Unzai; Yutaka Muto; Shigeyuki Yokoyama
Journal:  J Mol Biol       Date:  2009-08-14       Impact factor: 5.469

9.  Distinct intracellular motifs of Delta mediate its ubiquitylation and activation by Mindbomb1 and Neuralized.

Authors:  Aikaterini Daskalaki; Nevine A Shalaby; Kristina Kux; Giorgos Tsoumpekos; George D Tsibidis; Marc A T Muskavitch; Christos Delidakis
Journal:  J Cell Biol       Date:  2011-12-12       Impact factor: 10.539

10.  New classes of mind bomb-interacting proteins identified from yeast two-hybrid screens.

Authors:  Li-Chuan Tseng; Chengjin Zhang; Chun-Mei Cheng; Haoying Xu; Chia-Hao Hsu; Yun-Jin Jiang
Journal:  PLoS One       Date:  2014-04-08       Impact factor: 3.240
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  12 in total

Review 1.  The Canonical Notch Signaling Pathway: Structural and Biochemical Insights into Shape, Sugar, and Force.

Authors:  Rhett A Kovall; Brian Gebelein; David Sprinzak; Raphael Kopan
Journal:  Dev Cell       Date:  2017-05-08       Impact factor: 12.270

2.  E3 ubiquitin ligase Mindbomb 1 facilitates nuclear delivery of adenovirus genomes.

Authors:  Stephanie L Sarbanes; Vincent A Blomen; Eric Lam; Søren Heissel; Joseph M Luna; Thijn R Brummelkamp; Erik Falck-Pedersen; H-Heinrich Hoffmann; Charles M Rice
Journal:  Proc Natl Acad Sci U S A       Date:  2020-12-21       Impact factor: 11.205

Review 3.  Notch Signaling in T Helper Cell Subsets: Instructor or Unbiased Amplifier?

Authors:  Irma Tindemans; Marlies J W Peeters; Rudi W Hendriks
Journal:  Front Immunol       Date:  2017-04-18       Impact factor: 7.561

4.  Notch signaling represents an important checkpoint between follicular T-helper and canonical T-helper 2 cell fate.

Authors:  Mark Dell'Aringa; R Lee Reinhardt
Journal:  Mucosal Immunol       Date:  2018-02-21       Impact factor: 7.313

5.  Proximity interactions of the ubiquitin ligase Mind bomb 1 reveal a role in regulation of epithelial polarity complex proteins.

Authors:  Sascha E Dho; Nancy Silva-Gagliardi; Fabio Morgese; Etienne Coyaud; Emily Lamoureux; Donna M Berry; Brian Raught; C Jane McGlade
Journal:  Sci Rep       Date:  2019-08-28       Impact factor: 4.379

6.  MIB1 mutations reduce Notch signaling activation and contribute to congenital heart disease.

Authors:  Binbin Li; Liwei Yu; Dong Liu; Xueyan Yang; Yufang Zheng; Yonghao Gui; Hongyan Wang
Journal:  Clin Sci (Lond)       Date:  2018-12-05       Impact factor: 6.124

7.  A new gene inventory of the ubiquitin and ubiquitin-like conjugation pathways in Giardia intestinalis.

Authors:  Isabel Cristina Castellanos; Eliana Patricia Calvo; Moisés Wasserman
Journal:  Mem Inst Oswaldo Cruz       Date:  2020-02-21       Impact factor: 2.743

8.  A viral ubiquitination switch attenuates innate immunity and triggers nuclear import of virion DNA and infection.

Authors:  Michael Bauer; Alfonso Gomez-Gonzalez; Maarit Suomalainen; Nicolas Schilling; Silvio Hemmi; Urs F Greber
Journal:  Sci Adv       Date:  2021-12-17       Impact factor: 14.136

9.  Lys-63-linked Ubiquitination of γ-Aminobutyric Acid (GABA), Type B1, at Multiple Sites by the E3 Ligase Mind Bomb-2 Targets GABAB Receptors to Lysosomal Degradation.

Authors:  Khaled Zemoura; Claudia Trümpler; Dietmar Benke
Journal:  J Biol Chem       Date:  2016-08-29       Impact factor: 5.157

10.  The E3 Ubiquitin Ligase MIB-1 Is Necessary To Form the Nuclear Halo in Caenorhabditis elegans Sperm.

Authors:  Leslie A Herrera; Daniel A Starr
Journal:  G3 (Bethesda)       Date:  2018-07-02       Impact factor: 3.154
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