A retrospective study of six patients with mandibular metastatic carcinoma.

Mandibular metastatic carcinoma is a rare lesion that accounts for <1% of all oral malignancies. To provide greater experience in this field, the present study was conducted in which 6 cases of mandibular metastatic carcinoma were retrospectively reviewed. The origin of the lesions was the prostate in 2 cases, the lungs in 2 cases, the breast in 1 case and the thyroid gland in 1 case. The clinical and computed tomography features, surgical management and follow-up outcomes were investigated. The study indicated that surgeons should include the suspicion of metastasis in the differential diagnosis for mandibular tumor, particularly in patients who have a history of malignancy. A poor prognosis was associated with the examined patients. To extend the survival time as long as possible, a treatment strategy using multiple therapies, including segmental mandibulectomy, radiotherapy and chemotherapy, is recommended.

Introduction

Metastatic carcinoma of the mandible is a rare lesion that constitutes <1% of all oral malignancies (1). The primary tumors from which metastases occur most commonly arise in the breasts, lungs and prostate (1–3), followed by the kidney, thyroid gland, liver, stomach, intestines, testes and bladder (1,4–8). Surgeons often have little experience with mandibular metastatic carcinomas, hence, the majority of such tumors are mistakenly considered to be new primary growths until histological examination reveals their true metastatic nature (1,2). There are no clear differences in histological findings between metastatic and primary lesions, and the diagnosis of mandibular metastatic carcinoma is primarily based on biopsy rather than radiographical or physical examination (2,3). Usually, segmental mandibulectomy surgery, radiotherapy and chemotherapy are used to extend the survival time of patients, although a significant extension of survival time has yet to be achieved (9). However, a poor prognosis is associated with these patients (2,3,9). In an early study conducted by Clausen and Poulsen (3), 70 patients were observed following the recognition of the jaw metastasis; in total, 49 of these patients succumbed to the disease within one year, 6 within 2 years and 2 within 4 years.

In order to provide a greater experience of this condition, the present retrospective study was conduced to investigate the clinical and computed tomography (CT) features of 6 patients with mandibular metastatic carcinomas, including the surgical management options and follow-up outcomes.

Materials and methods

Patients

The medical records of 6 cases of mandibular metastatic carcinoma obtained between October 17, 2002, and October 24, 2009 from the Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine (Shanghai, China), were retrospectively reviewed. Only cases that reported the mandible site and had histological confirmation were included in the present study. The cases consisted of 4 women and 2 men, with an average age of 66.3 years (range, 51–81 years). The origin of the lesions was the prostate in 2 cases, the lungs in 2 cases, the breast in 1 case and the thyroid gland in 1 case (Table I).

Table I.

Information on the 6 patients with mandibular metastatic carcinoma.

Case no.	Gender/age, years	Site of tumor/size, cm	Chief complaint	MT history	Computed tomography scan	Pre-operative diagnosis	Surgical mode	Pathological diagnosis	Survival time, months
1	M/73	Body/5.0	Pain, swelling, numb chin	No	Osteoplastic lesion and periosteal reaction	Osteosarcoma	Segmental mandibulectomy	Metastatic prostatic adeno-Ca	49
2	M/81	Condyle/3.5	Pain, swelling, limitation of mouth opening	No	Osteoplastic lesion and periosteal reaction	Osteosarcoma	Segmental mandibulectomy	Metastatic prostatic adeno-Ca	60
3	F/63	Ascending ramus/4.0	Pain, swelling, numb chin	Lung adeno-Ca	Osteolytic lesion and periosteal reaction	Osteosarcoma or metastatic carcinoma	Segmental mandibulectomy	Metastatic lung adeno-Ca	12
4	F/71	Body/3.0	Pain, swelling	No	Radiolucent fibro-osseous lesion	Ameloblastoma	Enucleation	Metastatic lung adeno-Ca	8
5	F/59	Ascending ramus/3.0	Pain, swelling	No	Radiolucent fibro-osseous lesion	Ameloblastoma	Segmental mandibulectomy	Metastatic thyroid adeno-Ca	27
6	F/51	Body/4.0	Pain, swelling, numb chin	Ductal breast cancer	Osteolytic lesion and periosteal reaction	Osteosarcoma or metastatic carcinoma	Segmental mandibulectomy	Metastatic ductal breast cancer	Lost to follow-up

M, male; F, female; MT, malignant tumor; Ca, carcinoma.

Ethical approval was obtained from the Ethics Committee of Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine [approval no., 2015(98)].

Treatment

Clinical examinations and CT scans were performed in all 6 patients pre-operatively. With the exception of case 4, all patients were treated with a segmental mandibulectomy and post-operative chemoradiotherapy. The patient in case 4 was reluctant to undergo a mandibulectomy, thus conservative enucleation was used.

Diagnosis and follow-up

The post-operative pathological diagnoses were formed using histological images and immunohistochemistry. The post-operative follow-up period ranged from 8 to 60 months (mean, 31.2 months), which reflected the post-operative survival time.

Results

All 6 patients presented with mandibular pain and bone swelling, 3 patients experienced a numb chin and 1 patient presented with a limited degree of mouth opening. The patient in case 3 had a history of lung adenocarcinoma, while case 6 had a history of ductal breast cancer; each patient were surgically treated 1.5 years prior to the current admission. Prior to admission, the suspicion of primary recurrence was eliminated of the two patients by examination with regard to the relevant discipline. The remaining 4 patients had no history of malignant tumors.

CT scans (Fig. 1) showed that cases 1 and 2 exhibited osteoplastic lesions (Fig. 1A), while cases 3 and 6 presented with osteolytic masses (Fig. 1B); all 4 of these patients presented with the apparent radiographic feature of a periosteal reaction, which was suggestive of osteosarcoma (Fig. 1D and E). The tumors of the other 2 patients (cases 4 and 5) appeared as expansive and radiolucent masses, with the characteristics of fibro-osseous lesions (Fig. 1C and F).

Figure 1.

Computed tomography features of mandibular metastatic carcinoma. (A and D) Case 1: An osteoplastic lesion with a clear periosteal reaction; (B and E) case 3: An osteolytic lesion with a periosteal reaction; and (C and F) case 5: A radiolucent fibro-osseous lesion. (A, B and C show soft tissue windows, with a window width of 270 Hu and a window level of 35 Hu; D, E and F show bone windows, with a window width of 1,500 Hu and a window level of 400 Hu).

The pre-operative first diagnosis of the patients in cases 1, 2, 3 and 6 was mandibular osteosarcoma. For cases 3 and 6, considering their malignant history, metastatic carcinoma was formed as the second diagnosis following pre-operative CT. The other 2 patients (cases 4 and 5) were diagnosed with ameloblastoma mainly based on the CT characteristics.

In total, 5 of the patients (cases 1, 2, 3, 5 and 6) were surgically treated with an en bloc segmental mandibulectomy with a margin of normal bone, and subsequent adjuvant therapy consisting of radiotherapy and chemotherapy. For case 4, following the enucleation of the lesion, an intraoperative rapid-frozen biopsy provided the diagnosis of malignancy. However, a further extensive osteotomy was refused by the patient's family. Alternative chemoradiotherapy was selected instead. All patients were advised to visit the relevant respective departments of the hospital for further treatment of the primary site following discharge from the Department of Oral and Maxillofacial Surgery.

The pathological diagnosis of all 6 patients was metastatic carcinoma. Cases 1 and 2 originated from the prostate (Fig. 2A), with immunostaining of prostate-specific antigen in the atypical cells confirming the diagnosis of metastatic prostatic adenocarcinoma (Fig. 3A). Cases 3 and 4 originated from lung adenocarcinoma; adenoid structures and columnar epithelial cells with cellular nucleus division were observed (Fig. 2B). Case 5 originated from thyroid adenocarcinoma (Fig. 2C), with immunostaining testing positive for thyroglobulin in the cytoplasm of the nests of tumor tissues (Fig. 3B). Case 6 originated from breast ductal cancer; a large number of ductal carcinoma cell nests were surrounded by osseous trabecular structures (Fig. 2D).

Figure 2.

Histological images. (A) Case 1: A mandibular metastatic prostatic adenocarcinoma, with crushed adenocarcinoma cells found within the bone; (B) case 3: A mandibular metastatic lung adenocarcinoma, in which adenoid structures and columnar epithelial cells with cellular nucleus division was observed; (C) case 5: A mandibular metastatic thyroid adenocarcinoma, with tumor cells arranged in nests and growing within the bone; and (D) case 6: Mandibular metastatic ductal breast cancer, with ductal carcinoma cell nests surrounded by tumor connective tissue within the bone. Original magnification, ×200.

Figure 3.

Immunostaining. (A) Case 1: The overexpression of prostate-specific antigen in the atypical cells of the prostatic metastatic adenocarcinoma specimen; and (B) case 5, immunostaining of thyroglobulin in the atypical cells confirming the diagnosis of thyroid metastatic adenocarcinoma. Magnification, ×200.

Patients from cases 1, 3, 4 and 5 succumbed to cachexia caused by cancer recurrence or extensive metastasis during the follow-up period. The patient from case 2 succumbed due to cardiac disease 60 months after surgery, and case 6 was lost to follow-up, thus a survival time could not be acquired.

Discussion

In total, <1% of mandibular malignancies are metastatic lesions of a primary tumor originating in another region of the body (1,2). However, the actual morbidity rate may be even higher for the following reasons: i) Radiographic surveys of the jaws are not routine; ii) certain precancerous lesions and preinvasive carcinomas are hard to detect by radiographic examination; and iii) the jaws are seldom examined during autopsy (10–13).

Cases of primary carcinoma metastasizing to the mandible were previously reviewed in a study by D'Silva et al, which recorded the following primary sites: Breasts (25%), lungs (13%), prostate (10%), colon (7%), thyroid gland (3%) and kidneys (3%) (1). Metastasis of maxillofacial bone carcinoma to distant regions occurs primarily via the blood (2). However, there is a much higher frequency of metastasis development in the mandible compared with other maxillofacial bones (3,10). The exact reason for this is unknown. The mandible is fed by the terminal inferior alveolar artery, which is tightly encased by the annular mandibular marrow cavity (14). Furthermore, the pathway of the inferior alveolar artery traveling through the mandible is quite long. We speculate that these anatomical features are more suitable for the stagnation and gathering of tumor cells, and that the nutrient-rich red active marrow within the mandible is eligible for tumor proliferation.

In the present study, pain and swelling were the most common symptoms of the mandibular malignancies, but the most significant symptom was paresthesia of the chin. Nerve numbness has a close association with malignant tumors (3,15). Limitation of mouth opening was also found in the patient that presented with a condylar metastasis (case 2) in the present study. It should be noted that condylar metastasis with symptoms of temporomandibular joint pain and limited mouth opening could mimic temporomandibular disorders (TMD) (16–19). In this case, clinicians should be aware of the differential diagnosis of this tumor, particularly when patients have a history of malignancy or respond to TMD-therapy inappropriately (19).

In general, the primary tumor is diagnosed prior to the appearance of oral metastasis. However, in the present study, 4 out of the 6 cases experienced oral symptoms prior to diagnosis of the primary site. Furthermore, in certain cases, the primary malignancy remains undetected even though metastatic tumors of the jaw have been pathologically diagnosed (1).

CT is the conventional diagnostic tool for mandibular metastatic lesions (6). In the current study, the 2 prostatic metastatic cases presented with osteoplastic lesions, while others showed osteolytic change. A ‘sunburst’ periosteal reaction was observed in 4 lesions and the other 2 lesions showed a well-demarcated radiolucent fibro-osseous lesion. However, the diagnosis of mandibular metastatic carcinoma can be difficult to make based solely on CT features. For cases 3 and 6, due to the history of malignancy, the possibility of metastatic carcinoma was considered in the differential diagnosis, however, it was thought more likely that the lesion was a primary osteosarcoma according to the CT results.

The differential diagnosis for mandibular metastatic carcinoma includes TMD, ameloblastoma, primary intraosseous squamous carcinoma, and particularly, osteosarcoma (2,16,17,20,21). The past medical history, symptoms, clinical examination, and CT or magnetic resonance imaging (MRI) results of a patient should be carefully investigated. For patients with a history of malignancy, metastatic carcinoma must be considered in the differential diagnosis. As CT or MRI scans can provide uncharacteristic findings, biopsy is an essential and indispensable tool for forming a diagnosis (3). Additionally, if surgeons suspect that there is a possibility of metastases, then positron emission tomography (PET)/CT maybe required (22). PET/CT is usually an effective diagnostic tool for metastatic carcinoma, with the shortcoming of this equipment being its low popularity in developing regions.

Mandibular metastatic carcinoma is associated with a poor prognosis. The majority of patients diagnosed with oral metastasis succumb to the disease within 1 year, while the 4-year survival rate is estimated to be 10% (3,23). The main purpose of therapy is to relieve pain and extend the survival time. In the present study a collaborative therapeutic schedule that included surgical, chemical and radioactive treatment was recommended. Following this integrated therapy, and combined with androgen deprivation, the 2 patients in the prostatic metastatic cases achieved survival times of >4 years. By contrast, the patient in case 4 who rejected the extensive osteotomy succumbed to cachexia 8 months later. It should be noted that if extensive metastases have been detected pre-operatively or if the patient is in a bad general condition, palliative care may be the sensible choice.

As the general prognosis of such patients is rather poor, intraoperative immediate mandible reconstruction by bone transplantation, including fibular or iliac bone flaps, should be avoided to alleviate the risks and repercussions associated with surgery.

In conclusion, the diagnosis of mandibular metastatic carcinoma is rather difficult, particularly for patients who develop oral symptoms prior to the diagnosis of the primary site and in whom there is no history of malignancy. A poor prognosis is associated with these patients. To extend the survival time of such patients, a treatment strategy using multiple therapies, including segmental mandibulectomy, radiotherapy and chemotherapy, is recommended.