Min Zhou1,2,3, Marites Melancon4, R Jason Stafford5, Junjie Li1, Alpa M Nick6, Mei Tian2, Anil K Sood6,7, Chun Li8. 1. Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas. 2. Department of Nuclear Medicine and PET Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. 3. Institute of Translational Medicine, School of Medicine, Zhejiang University, Hangzhou, China. 4. Department of Interventional Radiology, The University of Texas MD Anderson Cancer Center, Houston, Texas. 5. Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas. 6. Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas; and. 7. Center for RNAi and Non-Coding RNA, The University of Texas MD Anderson Cancer Center, Houston, Texas. 8. Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas cli@mdanderson.org.
Abstract
Imaging-based techniques have enabled the direct integration of noninvasive imaging with minimally invasive interventions such as photothermal therapy (PTT) to improve the precision of treatment. METHODS: We investigated the feasibility of PTT for ovarian cancer under the guidance of PET and MR temperature imaging using copper sulfide nanoparticles (CuS NPs). The tumor distribution of the CuS NPs after systemic administration was assessed using highly sensitive, quantifiable PET imaging. Two wavelengths of near-infrared (NIR) lasers-808 and 980 nm-were tested for PTT using noninvasive MR temperature imaging real-time monitoring. RESULTS: The in vivo studies revealed that the 980-nm NIR laser had better photothermal effects than the 808-nm NIR laser. These results were in accord with the histologic findings. In vivo PTT using CuS NPs combined with 980-nm laser irradiation achieved significant tumor ablation compared with no treatment control in both subcutaneous (P = 0.007) and orthotopic (P < 0.001) models of ovarian cancer with regard to the percentage of necrotic damage. CONCLUSION: Our results indicate that real-time monitoring of the accuracy of PTT is a promising approach for future clinical translation of this emerging thermal ablation technique.
Imaging-based techniques have enabled the direct integration of noninvasive imaging with minimally invasive interventions such as photothermal therapy (PTT) to improve the precision of treatment. METHODS: We investigated the feasibility of PTT for ovarian cancer under the guidance of PET and MR temperature imaging using copper sulfide nanoparticles (CuS NPs). The tumor distribution of the CuS NPs after systemic administration was assessed using highly sensitive, quantifiable PET imaging. Two wavelengths of near-infrared (NIR) lasers-808 and 980 nm-were tested for PTT using noninvasive MR temperature imaging real-time monitoring. RESULTS: The in vivo studies revealed that the 980-nm NIR laser had better photothermal effects than the 808-nm NIR laser. These results were in accord with the histologic findings. In vivo PTT using CuS NPs combined with 980-nm laser irradiation achieved significant tumor ablation compared with no treatment control in both subcutaneous (P = 0.007) and orthotopic (P < 0.001) models of ovarian cancer with regard to the percentage of necrotic damage. CONCLUSION: Our results indicate that real-time monitoring of the accuracy of PTT is a promising approach for future clinical translation of this emerging thermal ablation technique.
Authors: Min Zhou; Rui Zhang; Miao Huang; Wei Lu; Shaoli Song; Marites P Melancon; Mei Tian; Dong Liang; Chun Li Journal: J Am Chem Soc Date: 2010-11-03 Impact factor: 15.419
Authors: Andreas du Bois; Alexander Reuss; Eric Pujade-Lauraine; Philipp Harter; Isabelle Ray-Coquard; Jacobus Pfisterer Journal: Cancer Date: 2009-03-15 Impact factor: 6.860
Authors: Alexander L Antaris; Joshua T Robinson; Omar K Yaghi; Guosong Hong; Shuo Diao; Richard Luong; Hongjie Dai Journal: ACS Nano Date: 2013-04-03 Impact factor: 15.881
Authors: Krishna L Kanchi; Kimberly J Johnson; Charles Lu; Michael D McLellan; Mark D M Leiserson; Michael C Wendl; Qunyuan Zhang; Daniel C Koboldt; Mingchao Xie; Cyriac Kandoth; Joshua F McMichael; Matthew A Wyczalkowski; David E Larson; Heather K Schmidt; Christopher A Miller; Robert S Fulton; Paul T Spellman; Elaine R Mardis; Todd E Druley; Timothy A Graubert; Paul J Goodfellow; Benjamin J Raphael; Richard K Wilson; Li Ding Journal: Nat Commun Date: 2014 Impact factor: 14.919