Literature DB >> 2728346

ts1, a mutant of Moloney murine leukemia virus-TB, causes both immunodeficiency and neurologic disorders in BALB/c mice.

P K Wong1, G Prasad, J Hansen, P H Yuen.   

Abstract

BALB/c mice infected with ts1, a mutant of Moloney murine leukemia virus-TB, develop generalized body wasting, profound neurologic disorders, severe thymic atrophy and lymphopenia due to destruction of T lymphocytes and drastic immunodeficiency. ts1 was found not only able to infect T lymphocytes but also to impair their function. In addition, ts1 also infects and induces syncyntia formation in macrophages. The genetic determinant(s) responsible for ts1's ability to induce immunodeficiency has been localized to the env gene.

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Year:  1989        PMID： 2728346     DOI： 10.1016/0042-6822(89)90436-4

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  17 in total

1.  Site-directed mutagenesis of the codon for Ile-25 in gPr80env alters the neurovirulence of ts1, a mutant of Moloney murine leukemia virus TB.

Authors:  P F Szurek; E Floyd; P H Yuen; P K Wong
Journal:  J Virol       Date:  1990-11       Impact factor: 5.103

2.  Neuroprotective effects of the drug GVT (monosodium luminol) are mediated by the stabilization of Nrf2 in astrocytes.

Authors:  Pichili Vijaya Bhaskar Reddy; Gina Lungu; Xianghong Kuang; George Stoica; Paul K Y Wong
Journal:  Neurochem Int       Date:  2010-03-06       Impact factor: 3.921

3.  Correlation of specific virus-astrocyte interactions and cytopathic effects induced by ts1, a neurovirulent mutant of Moloney murine leukemia virus.

Authors:  E Shikova; Y C Lin; K Saha; B R Brooks; P K Wong
Journal:  J Virol       Date:  1993-03       Impact factor: 5.103

4.  Down-regulation of Jab1, HIF-1alpha, and VEGF by Moloney murine leukemia virus-ts1 infection: a possible cause of neurodegeneration.

Authors:  Gina F Lungu; George Stoica; Paul K Y Wong
Journal:  J Neurovirol       Date:  2008-05       Impact factor: 2.643

5.  Studies on the pathology, especially brain lesions, induced by R7, a spontaneous mutant of Moloney murine sarcoma virus 124.

Authors:  P H Yuen; Y T Kwak
Journal:  Am J Pathol       Date:  1998-06       Impact factor: 4.307

6.  Astrocytes survive chronic infection and cytopathic effects of the ts1 mutant of the retrovirus Moloney murine leukemia virus by upregulation of antioxidant defenses.

Authors:  Wenan Qiang; Xianghong Kuang; Jinrong Liu; Na Liu; Virginia L Scofield; Amy J Reid; Yuhong Jiang; Gheorghe Stoica; William S Lynn; Paul K Y Wong
Journal:  J Virol       Date:  2006-04       Impact factor: 5.103

7.  Alteration from T- to B-cell tropism reduces thymic atrophy and cytocidal effects in thymocytes but not neurovirulence induced by ts1, a mutant of Moloney murine leukemia virus TB.

Authors:  P K Wong; P F Szurek; E Floyd; K Saha; B R Brooks
Journal:  Proc Natl Acad Sci U S A       Date:  1991-10-15       Impact factor: 11.205

8.  Cardiac disease in transgenic mice expressing human immunodeficiency virus-1 nef in cells of the immune system.

Authors:  Denis G Kay; Ping Yue; Zaher Hanna; Serge Jothy; Etienne Tremblay; Paul Jolicoeur
Journal:  Am J Pathol       Date:  2002-07       Impact factor: 4.307

9.  A Val-25-to-Ile substitution in the envelope precursor polyprotein, gPr80env, is responsible for the temperature sensitivity, inefficient processing of gPr80env, and neurovirulence of ts1, a mutant of Moloney murine leukemia virus TB.

Authors:  P F Szurek; P H Yuen; J K Ball; P K Wong
Journal:  J Virol       Date:  1990-02       Impact factor: 5.103

10.  ts1, a temperature-sensitive mutant of Moloney murine leukemia virus TB, can infect both CD4+ and CD8+ T cells but requires CD4+ T cells in order to cause paralysis and immunodeficiency.

Authors:  K Saha; P K Wong
Journal:  J Virol       Date:  1992-05       Impact factor: 5.103
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